A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view

Shin, Ok Ran; Kim, Yang Ree; Ban, Tae-Hyun; Lim, Tae-Seok; Han, Tae-Hee; Kim, Su Yeon; Seo, Kyung Jin

doi:10.1186/1746-1596-9-62

Cited by 11 publications

(5 citation statements)

References 22 publications

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“…Physicians are familiar with cat scratch disease (CSD), a benign self-limiting infection that generally resolves spontaneously without the need for antibiotic administration. 19 In contrast to classical CSD, recent evidence indicates that B henselae , the primary or sole cause of CSD, can be isolated from the blood of healthy blood donors, 20 at-risk animal health workers, 9 , 10 and patients with rheumatologic 21 - 23 and neuropsychiatric symptoms. 4 , 5 Proving disease causation for stealth pathogens, such as Bartonella spp., is challenging 24 and a One Health approach 16 has been proposed to more effectively characterize the comparative medical importance of this genus.…”

Section: Discussionmentioning

confidence: 99%

Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome

Breitschwerdt

Greenberg

Maggi

et al. 2019

J Cent Nerv Syst Dis

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Background:With the advent of more sensitive culture and molecular diagnostic testing modalities, Bartonella spp. infections have been documented in blood and/or cerebrospinal fluid specimens from patients with diverse neurological symptoms. Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by an unusually abrupt onset of cognitive, behavioral, or neurological symptoms. Between October 2015 and January 2017, a 14-year-old boy underwent evaluation by multiple specialists for sudden-onset psychotic behavior (hallucinations, delusions, suicidal and homicidal ideation).Methods:In March 2017, Bartonella spp. serology (indirect fluorescent antibody assays) and polymerase chain reaction (PCR) amplification, DNA sequencing, and Bartonella enrichment blood culture were used on a research basis to assess Bartonella spp. exposure and bloodstream infection, respectively. PCR assays targeting other vector-borne infections were performed to assess potential co-infections.Results:For 18 months, the boy remained psychotic despite 4 hospitalizations, therapeutic trials involving multiple psychiatric medication combinations, and immunosuppressive treatment for autoimmune encephalitis. Neurobartonellosis was diagnosed after cutaneous lesions developed. Subsequently, despite nearly 2 consecutive months of doxycycline administration, Bartonella henselae DNA was PCR amplified and sequenced from the patient’s blood, and from Bartonella alphaproteobacteria growth medium enrichment blood cultures. B henselae serology was negative. During treatment with combination antimicrobial chemotherapy, he experienced a gradual progressive decrease in neuropsychiatric symptoms, cessation of psychiatric drugs, resolution of Bartonella-associated cutaneous lesions, and a return to all pre-illness activities.Conclusions:This case report suggests that B henselae bloodstream infection may contribute to progressive, recalcitrant neuropsychiatric symptoms consistent with PANS in a subset of patients.

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Section: Discussionmentioning

confidence: 99%

Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome

Breitschwerdt

Greenberg

Maggi

et al. 2019

J Cent Nerv Syst Dis

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“…On color Doppler, these masses typically demonstrate hila with vascular flow consistent with enlarged intramammary lymph nodes. Biopsy may be necessary in elusive cases [60,61]. Histopathology is characterized by reactive follicular hyperplasia and geographic microabscess formation representing necrotizing lymphadenitis [62].…”

Section: Cat Scratch Diseasementioning

confidence: 99%

“The unusual suspects”—Mammographic, sonographic, and histopathologic appearance of atypical breast masses

et al. 2020

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Breast malignancy is the second most common cause of cancer death in women. However, less common breast masses can mimic carcinoma and can pose diagnostic challenges. This case-based review describes a spectrum of rare breast neoplastic and non-neoplastic masses ranging from malignant to benign entities. Malignant masses in this review include adenoid cystic carcinoma, spindle cell lipoma, granular cell tumor, angiosarcoma, glomus tumor, adenosquamous carcinoma, and myofibroblastoma. Benign masses include sarcoidosis, diabetic mastopathy, and cat scratch disease. Demographics and, when relevant, clinical presentation are summarized. Breast imaging appearance on mammography and ultrasound are highlighted along with radiology-pathology correlation with the appearance and characteristics of the histopathological specimen of these rare masses.

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“…Non-Hodgkin’s lymphoma) or infectious diseases (e.g. TbL or cat scratch disease [18]) or concurrent systemic lupus erythematosus (SLE). A recent study [19] reported 12% KFD patients had a history of SLE.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease: a case report and the evaluation of diagnostic procedures

Xu¹,

Sun²,

Liu³

2019

BMC Oral Health

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Background: Kikuchi-Fujimoto disease, known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting and systemic disorder involving lymph nodes with unknown aetiology. First reported in Japan, there has been an increase in its incidence globally. Because of its non-specific clinical features, the disease can be easily mistaken for other forms of lymphadenitis with a high rate of misdiagnosis and mistreatment, posing a considerable challenge. Case presentation: A case of young Chinese woman with fever and cervical lymphadenopathy is presented. Physical examinations and imaging techniques were used to rule out common forms of lymphadenitis (e.g. cat-scratch disease and tuberculous lymphadenitis). Laboratory tests were then conducted to exclude others such as systemic lupus erythematosus and non-Hodgkin lymphoma. After Kikuchi-Fujimoto disease was identified, the patient was managed with symptomatic treatments. Our case was compared with relevant cases in the literature. A diagnostic flow chart was proposed to facilitate the diagnosis and treatment. Conclusions: With its shared clinical features, Kikuchi-Fujimoto disease can be mistaken for other forms of lymphadenitis. A combined use of medical imaging and laboratory tests is the effective way to avoid misdiagnosis.

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A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view

Cited by 11 publications

References 22 publications

Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome

Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome

“The unusual suspects”—Mammographic, sonographic, and histopathologic appearance of atypical breast masses

Kikuchi-Fujimoto disease: a case report and the evaluation of diagnostic procedures

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