A Case Report On Congestive Cardiac Failure Due To Hyperthyroidism

Yakasai, BA; Yakasai, HB

doi:10.15226/2374-6882/5/1/00143

Cited by 2 publications

(7 citation statements)

References 27 publications

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“…Thus, SAT AtCurS2 faithfully transferred the on-program tetraketide or pentaketide priming units offered by the hrPKS noncognate partners, with the exception of 5Pb, the priming unit from CcRadS1. On the contrary, SAT RrDalS2 displayed a clear intrinsic selectivity, consistently choosing shorter, and if possible triketide priming units at the expense of longer, especially pentaketide ones (Entries #7,#9,#14,#16,#21,#23,#28,#30,#34 and #36,Fig. 2).…”

Section: Sat Domains Are Proactive Selectors Contributing To the Hrpks Metaprogrammentioning

confidence: 99%

“…Thus, TE AtCurS2 is a permissive gatekeeper that successfully releases heptaketide, octaketide and nonaketide products derived from triketide, tetraketide or pentaketide priming units, respectively. In particular, TE AtCurS2 facilitates the efficient production of triketide-primed polyketides when this domain and SAT RrDalS2 are appended to an AtCurS2 or RrDalS2 chassis (Entries #7,#9,#14,#16,#21,#23,#28,#30,#34 and #36,Fig. 2).…”

Section: Sat and Te Domain Interactions Influence The Bdl Synthase Metaprogrammentioning

confidence: 99%

“…Highly reducing PKSs (hrPKSs) harboring ketoacyl reductase (KR), dehydratase (DH), and enoyl reductase (ER) domains execute a cryptic biosynthetic program to selectively reduce the nascent β-keto moieties after each chain extension step into a β-alcohol, an alkene, or an alkane. [5][6][7] Partially reducing PKSs lack ER domains and afford relatively simple cyclic structures. 8 Finally, nonreducing PKSs (nrPKSs) lack all reductive domains, but incorporate a starter unit : ACP transacylase (SAT) domain for priming unit selection, 9,10 and a product template (PT) domain for regiospecific closure of the first aromatic ring.…”

Section: Introductionmentioning

confidence: 99%

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Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases

Wang

Zhang

et al. 2020

J. Am. Chem. Soc.

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Combinatorial biosynthesis with fungal polyketide synthases (PKSs) promises to produce unprecedented bioactive "unnatural" natural products (uNPs) for drug discovery. Genome mining of the dothideomycete Rhytidhysteron rufulum uncovered a collaborating highly reducing PKS (hrPKS) -nonreducing PKS (nrPKS) pair. These enzymes produce trace amounts of rare S-type benzenediol macrolactone congeners with a phenylacetate core in a heterologous host. However, subunit shuffling and domain swaps with voucher enzymes demonstrated that all PKS domains are highly productive. This contradiction led us to reveal novel programming layers exerted by the starter unit acyltransferase (SAT) and the thioesterase (TE) domains on the PKS system. First, macrocyclic vs. linear product formation is dictated by the intrinsic biosynthetic program of the TE domain. Next, the chain length of the hrPKS product is strongly influenced in trans by the offloading preferences of the nrPKS SAT domain. Last, TE domains are size-selective filters that facilitate or obstruct product formation from certain priming units. Thus, the intrinsic programs of the SAT and TE domains are both part of the extrinsic program of the hrPKS subunit, and modulate the observable metaprogram of the whole PKS system. Reconstruction of SAT and TE *

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Section: Sat Domains Are Proactive Selectors Contributing To the Hrpks Metaprogrammentioning

confidence: 99%

Section: Sat and Te Domain Interactions Influence The Bdl Synthase Metaprogrammentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases

Wang

Zhang

et al. 2020

J. Am. Chem. Soc.

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“…2 Thyroid hormone has cardiac effects directly on the heart and indirectly through its impact on vasculature and body metabolism. 5 In addition, thyroid hormones affect cardiac intracellular pathways by genomic and non-genomic mechanisms. 6 Thyroid hormones upregulate myocardial contractility, resting heart rate, and blood volume compared to expected.…”

Section: Discussionmentioning

confidence: 99%

“…The thyroid hormone's influence on various ion channels mediates the non-transcriptional effects. 5 Thyroid hormone can affect the sinus node directly and increase the heart rate. 7 T3 has been found to reduce systemic vascular resistance (SVR) via inducing vasodilation on the periphery.…”

Section: Discussionmentioning

confidence: 99%

The Importance of Hyperthyroid Screening in Acute Decompensated Heart Failure with Persistent Tachycardia Despite Optimal Decongestion: A Case Report

Wijayanto,

Myrtha,

Prabowo

2022

IJC

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Background: Hyperthyroid has various effects on the cardiovascular system. Cardiac arrhythmias ranging from sinus tachycardia to atrial fibrillation and low/high cardiac output state to congestive heart failure are observed in patients with hyperthyroidism. If hyperthyroidism is recognized and treated early, the cardiac dysfunction could be corrected. This case presentation will discuss the importance of thyroid function screening. Case Illustration and Discussion: A man was admitted to the emergency department with signs and symptoms of acute decompensated heart failure. Further examination was performed to confirm the diagnosis, namely ECG, laboratory examination including thyroid function test, and echocardiography. During hospitalization, heart failure medication was given and up titrated. The patient was still tachycardia until hyperthyroid was corrected with anti-thyroid medicines. Conclusion: Hyperthyroidism can cause or worsen left ventricular dysfunction, especially in individuals with a history of cardiovascular disease. Thus, thyroid function tests should be assessed during initial laboratory examination, especially on patients with acute decompensated heart failure.

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A Case Report On Congestive Cardiac Failure Due To Hyperthyroidism

Cited by 2 publications

References 27 publications

Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases

Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases

The Importance of Hyperthyroid Screening in Acute Decompensated Heart Failure with Persistent Tachycardia Despite Optimal Decongestion: A Case Report

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