A Case Series of Neuropsychological Outcome After Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Refractory Obsessive–Compulsive Disorder

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive–Compulsive Disorder: A Systematic Review

“…The full text of these 43 articles was examined, and an additional 29 studies were excluded. In addition, we included our own case series, resulting in the final inclusion of 15 studies comprising 178 patients with severe treatment-resistant OCD who underwent DB 12 (Table 1). Study designs were heterogeneous, including, among others, randomized control trials, openlabel studies, and case series (Table 1).…”

“…Compared to baseline the TMT ratio (Time B/Time A) showed a significant increase of 0.94 (SD = ±0.95, p = 0.018) with a medium effect size of 0.63 due to improvement on the TMT-A and a trend toward a worsened TMT-B. 12…”

“…Grassi et al 19 assessed impulsivity and decision making in 20 OCD patients receiving vALIC DBS, compared to healthy controls and conventional OCD treatment. Total YBOCS scores decreased from (median [interquartile range]) 32.5 (30-35) to 17.5 (12-20.5) for the DBS-treated patients and 29.5 (21.5-34) to 19 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) for the patients treated as usual. Decision-making performances and impulsivity were evaluated under the ambiguity on the Iowa Gambling Task (IGT) and the Beads Task (BT), respectively.…”

“…In Bouwens and Duits, 12 we described the neuropsychological outcome data of seven patients receiving DBS of the VC/VS with a mean YBOCS reduction of 12.14 after a mean follow-up of 18 months. Compared to baseline the TMT ratio (Time B/Time A) showed a significant increase of 0.94 (SD = ±0.95, p = 0.018) with a medium effect size of 0.63 due to improvement on the TMT-A and a trend toward a worsened TMT-B.…”