A Case Series of Puffer Fish Poisoning

Wan, CK; Tsui, S. L.; Tong, HK

doi:10.1177/102490790701400404

Cited by 13 publications

(8 citation statements)

References 15 publications

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“…PFP has been reported frequently during 1980e1999, 912 people in Japan were ill and 106 people died (mortality rate 11.62%) (Fukushima and Ohtsuka, 2005). Outbreaks of PFP also occurred in Hong Kong, Malaysia, Singapore, Australia, Bangladesh, and Taiwan (Chew et al, 1983;Chua and Chew, 2009;How et al, 2003;Isbister et al, 2002;Islam et al, 2011;Wan et al, 2007). In Thailand, Kanchanapongkul (2001) also reported 25 cases of PFP between 1989 and 1999 (Kanchanapongkul, 2001).…”

Section: Introductionmentioning

confidence: 88%

TaqMan qPCR for detection and quantification of mitochondrial DNA from toxic pufferfish species

Luekasemsuk

Panvisavas

Chaturongakul

2015

Toxicon

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Section: Introductionmentioning

confidence: 88%

TaqMan qPCR for detection and quantification of mitochondrial DNA from toxic pufferfish species

Luekasemsuk

Panvisavas

Chaturongakul

2015

Toxicon

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“…Although a number of TTX intoxication case reports have been published [ 10 , 26 , 46 , 47 ] most do not report the urine and/or blood TTX concentrations in patients. Zimmer has tried to find correlation between blood TTX concentrations and the poisoning symptoms [ 48 ].…”

Section: Correlation Between Blood and Urine Ttx Concentrations Anmentioning

confidence: 99%

Analytical Challenges: Determination of Tetrodotoxin in Human Urine and Plasma by LC-MS/MS

2011

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Tetrodotoxin (TTX) is a powerful sodium channel blocker found in puffer fish and some marine animals. Cases of TTX poisoning most often result from puffer fish ingestion. Diagnosis is mainly from patient’s signs and symptoms or the detection of TTX in the leftover food. If leftover food is unavailable, the determination of TTX in the patient’s urine and/or plasma is essential to confirm the diagnosis. Although various methods for the determination of TTX have been published, most of them are for food tissue samples. Dealing with human urine and blood samples is much more challenging. Unlike in food, the amount of toxin in the urine and blood of a patient is generally extremely low; therefore a very sensitive method is required to detect it. In this regard, mass spectrometry (MS) methods are the best choice. Since TTX is a very polar compound, there will be lack of retention on conventional reverse-phase columns; use of ion pair reagent or hydrophilic interaction liquid chromatography (HILIC) can help solve this problem. The problem of ion suppression is another challenge in analyzing polar compound in biological samples. This review will discuss different MS methods and their pros and cons.

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“…A secure and favorable result may be ensured by earlier detection and therapeutic interventions. Despite the rarity of pufferfish toxicity in our everyday practice, emergency doctors should be knowledgeable about the sign and symptoms, and therapy and be prepared to deal with these possibly deadly intoxications [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Tetrodotoxin Poisoning Due to Pufferfish Ingestion in the United Arab Emirates

Dhuhaibat¹,

Zarzour²

2023

Cureus

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Tetrodotoxin is a potent neurotoxin that is found in the ovaries and liver of pufferfish. This lethal toxin is heat stable and does not destroy by cooking that is why precaution should be taken when eating pufferfish. A 60-year-old male presented to the ED after eating pufferfish complaining of perioral and hand numbness, gait disturbance, and generalized body weakness. This presentation is due to a tetrodotoxin found in and not limited to the pufferfish he ingested. Despite having pufferfish with his family, he was the sole person to have symptoms because, unlike the other family members, he ate from the liver part of the fish.The patient was admitted for observation, received supportive care, and underwent multiple investigations that most came to be normal. He improved gradually and was discharged after staying for three nights in the hospital. Symptoms after eating the toxic parts of a pufferfish may progress to paralysis, and respiratory failure, and may lead to death. It is not common to have such fish eaten in the United Arab Emirates due to its limited availability.

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A Case Series of Puffer Fish Poisoning

Cited by 13 publications

References 15 publications

TaqMan qPCR for detection and quantification of mitochondrial DNA from toxic pufferfish species

TaqMan qPCR for detection and quantification of mitochondrial DNA from toxic pufferfish species

Analytical Challenges: Determination of Tetrodotoxin in Human Urine and Plasma by LC-MS/MS

Tetrodotoxin Poisoning Due to Pufferfish Ingestion in the United Arab Emirates

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