Melittin (MLT), also known as allergen Api m4 (Hossen et al., 2017), is the main compound of BV, comprising approximately 40-60% of its dry weight. MLT (together with apamin) has been reported to be found only in bee venom produced by the genus Apis (Moreno and Giralt, 2015). It is a linear, amphipathic, cationic and a-helical polypeptide molecule composed of 26 amino acid residues and is soluble in water (Silva et al., 2015; Kachel et al., 2018). Recent studies provided evidence on several biological properties of MLT (Table 1). MLT has been reported to be a very potent anti-inflammatory agent, being 100 times more potent than hydro-cortisol in animal models (Vick and Shipman, 1972; Eze et al., 2016). The antiinflammatory activity of this compound has been explored in several settings, including acne vulgaris, neuro inflammation, atherosclerosis, arthritis and liver inflammation (Lee and Bae, 2016).