A Case Study of Gut Fermentation Syndrome (Auto-Brewery) with &amp;lt;i&amp;gt;Saccharomyces cerevisiae&amp;lt;/i&amp;gt; as the Causative Organism

Cordell, Barbara; McCarthy, J.-A.

doi:10.4236/ijcm.2013.47054

Cited by 34 publications

(52 citation statements)

References 14 publications

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“…Alcoholic fermentation, typically performed by yeasts, should be distinguished from lactic fermentation, more common in anaerobic bacteria. A few cases have been reported of people suffering from Gut Fermentation Syndrome (31,32). Such patients had up to 2 g/L of alcohol in their blood, without any alcohol intake.…”

Section: Dsf Neuronal Toxicity ?mentioning

confidence: 99%

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Trautmann

Gascan

Ghozzi³

2020

Front. Med.

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Recently, disulfiram has been proposed as a promising treatment for people suffering from persistent symptoms of Lyme Disease. Disulfiram has several distinct molecular targets. The most well-known is alcohol dehydrogenase, a key enzyme for detoxifying the organism after alcohol ingestion. Other targets and modes of action of disulfiram, that may present problematic side effects, are less commonly mentioned. The French Federation against Tick Borne Diseases (French acronym, FFMVT), which associates three main Lyme patient organizations, MDs and PhDs, has recently been alerted to severe and persistent toxic events in a patient suffering from a late disseminated form of Lyme Disease following disulfiram intake. FFMVT reacted by launching a national call to examine whether other patients in France following a similar treatment could be identified, and what benefits, or side effects could be reported. The statements of 16 patients taking disulfiram have been collected and are presented here. Thirteen out of 16 patients reported toxic events, and seven out of 16 reported benefits for at least part of their symptoms. Based on the collected observations, it seems too early to promote disulfiram as a promising new treatment until the reasons underlying the reported toxicities have been explored, and the results of a well-conducted double blind clinical trial published. The importance of taking into account patient-reported outcomes in Lyme Disease is underlined by the present study.

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Section: Dsf Neuronal Toxicity ?mentioning

confidence: 99%

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Trautmann

Gascan

Ghozzi³

2020

Front. Med.

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“…For various reasons, the reliability of the results of forensic alcohol analysis is often challenged by defense. One such argument for produced acquittal concerns the notion that alcohol could be produced naturally in the body, hence the term "auto brewery" syndrome [1].…”

Section: Introductionmentioning

confidence: 99%

“…It is assumed that micro-flora in the gastrointestinal tract is the source of these alcohols (auto brewing), as well as from intermediary metabolism, [1] and amount that formed subsequently oxidized in the liver by the alcoholic dehydrogenase enzyme [2].…”

Section: Introductionmentioning

confidence: 99%

Endogenous Ethanol Production Levels in Saudi Arabia Residents

Ragab¹

2015

J Alcohol Drug Depend

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The word "endogenous" means produced or originating from within the body, so endogenous ethanol therefore implies a spontaneous auto regulation of ethanol through various human metabolic processes. In the current research, endogenous ethanol concentrations in blood were determined by sensitive headspace gas chromatography/mass Spectrophotometry in 1400 residents of Saudi Arabia. The subjects were from 14 nationalities, of both sexes and of different age groups. There was no significance difference in blood ethanol concentration between nationalities or between sexes within and between nationalities. The data was extracted and the overall mean ± SD, minimum, maximum, 5% percentile and 95% percentile were 0.14, ± 0.35, 0.00, 1.53 , 0.00, 1.20 mg/dl respectively. The values of blood ethanol concentration as reported in this study indicate they are far too low to have any forensic significance.

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“…Because of the claims of intoxication without drinking and the findings on endogenous alcohol fermentation, a new syndrome called Gut Fermentation Syndrome was described (5). This syndrome also goes by several other names, such as Auto-Brewery Syndrome, Syndrome A and Endogenous Ethanol Fermentation (5). The underlying mechanism is thought to be an overgrowth of yeast in the gut whereby the yeast ferments carbohydrates into ethanol.…”

Section: Claims Of Endogenous Fermentation Of This Type Have Been Usementioning

confidence: 99%

“…cerevisiae has mostly been identified as a pathogen in critically ill patients who are immunocompromised (10,11). Not one single article could be found on an S. cerevisiae infection in an otherwise healthy, immuno-competent adult (5).…”

Section: Diagnostic Proceduresmentioning

confidence: 99%

Gut fermentation syndrome

Fayemiwo¹,

Adegboro²

2013

Af J Clin Exp Micro

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Fungi have not been recognized to cause such notable syndromes until very recently. It has been documented among few individuals who became intoxicated after consuming carbohydrates, which became fermented in the gastrointestinal tract. These claims of intoxication without drinking alcohol, and the findings on endogenous alcohol fermentation are now called Gut Fermentation Syndrome. This review will concentrate on understanding the aetiology, clinical manifestations, laboratory diagnostic options and treatment of the syndrome.

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A Case Study of Gut Fermentation Syndrome (Auto-Brewery) with <i>Saccharomyces cerevisiae</i> as the Causative Organism

Cited by 34 publications

References 14 publications

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease

Endogenous Ethanol Production Levels in Saudi Arabia Residents

Gut fermentation syndrome

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