This study proposes a simple and replicable methodology to prioritize mining exploration projects based on their geoscientific characteristics and contextual factors, which can be adapted to different mining contexts. Using the Tiltil Mining District in Central Chile as a case study, where over 100 small and medium-sized Au and Cu prospects exist, this research outlines three key stages: (1) collection of relevant data; (2) selection of the most appropriate multi-criteria decision-making methods (MCDMs); and (3) the application, analysis, and comparison of these methods. This study identifies AHP and PROMETHEE II as the most suitable MCDM for the case study. The application of these methods consistently ranked El Huracán, San Aurelio, and La Despreciada as the top three exploration priorities. The AHP’s weight assignment highlights economic, geological, and social factors as the most critical variables in determining project viability.