A causal role for parvovirus B19 infection in adult dermatomyositis and other autoimmune syndromes

Crowson, A. Neil; Magro, Cynthia M.; Dawood, Magdy

doi:10.1034/j.1600-0560.2000.027010505.x

Cited by 91 publications

(42 citation statements)

References 38 publications

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“…The pathological findings included pauci inflammatory, perivascular cuffing of the microvasculature with reduplication/thickening of the basement membrane. Magro identified similar pathological changes in dermatomyositis, scleroderma, and idiopathic pulmonary fibrosis [28][29][30][31][32]. The pathology of SS most closely represents that seen in dermatomyositis, in which there is microinfarction of muscle and skin instead of brain, retina and inner ear.…”

Section: Pathologymentioning

confidence: 80%

Susac's syndrome: 1975–2005 microangiopathy/autoimmune endotheliopathy

Susac¹,

Egan²,

Rennebohm³

et al. 2007

Journal of the Neurological Sciences

202

164

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Section: Pathologymentioning

confidence: 80%

Susac's syndrome: 1975–2005 microangiopathy/autoimmune endotheliopathy

Susac¹,

Egan²,

Rennebohm³

et al. 2007

Journal of the Neurological Sciences

202

164

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“…In the last decade several articles have appeared implicating this virus pathogenically in different unusual cutaneous manifestations including papular-purpuric gloves-and-socks syndrome [4], dermatomyositis-like rash [5], chronic urticaria [6], Henoch-Schönlein purpura [7], systemic sclerosis [8], pityriasis lichenoides [9,10], psoriasis [11] and Behçet’s diseases [12]. The association of the B19 virus with these diseases has been established by the serological documentation of recent infections and the presence of B19 DNA in the peripheral blood and/or in the affected tissues.…”

Section: Introductionmentioning

confidence: 99%

Parvovirus B19 DNA Is Commonly Harboured in Human Skin

Bonvicini¹,

Plaça

Manaresi³

et al. 2010

Dermatology

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Background: Parvovirus B19 is the aetiological agent of erythema infectiosum. The presence of B19 DNA in lesional skin of other cutaneous manifestations has frequently been reported although there is disagreement on the role of the B19 virus in tissues. Objectives: To investigate the presence of B19 DNA (1) in skin lesions of patients with a described B19-related disease, (2) in skin lesions of B19-unrelated diseases and (3) in healthy skin. Methods: A total of 121 skin samples were examined for the presence of B19 DNA by PCR assays and peptide-nucleic-acid-based in situ hybridisation techniques. Results: B19 DNA was detected in 11/38 (28.9%) pityriasis lichenoides, 8/30 (26.7%) melanocytic naevi, 5/29 (17.2%) primary melanomas and 6/24 (25.0%) healthy skin biopsies. A difference in B19 DNA prevalence was observed in specimens grouped according to age, irrespective of pathologies. Conclusions: B19 DNA can be found in skin tissues of patients with pityriasis lichenoides as well as in lesions not related to B19 infection and in healthy controls. B19 DNA can be detected in skin of young subjects in a significantly high rate compared to adults, suggesting that viral persistence may be the usual outcome after primary infection.

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“…Parvovirus B19 has been proposed as a causative agent in rheumatoid disease and other vascular injury syndromes, including Wegener granulomatosis (24), microscopic polyarteritis nodosa (25), Henoch-Schönlein purpura (26), and dermatomyositis (27) in SSc. A direct correlation between the extent of degenerative endothelial cell alterations and the degree of B19RNA expression suggested a causal role of B19 in the propagation of endothelial cell dysfunction (28).…”

Section: Discussionmentioning

confidence: 99%

The prevalence of infectious agents in patients with systemic sclerosis

BİLGİN>¹,

KOCABAŞ²,

KEŞLİ³

2015

Turk J Med Sci

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Background/aim: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular injury, excessive extracellular matrix deposition, and fibrosis in the skin and internal organs. Bacterial and viral infectious agents have been suspected to be contributing factors in the development and progression of the pathologic features of SSc. Materials and methods:In this study, 30 SSc patients who were admitted to the rheumatology unit of the Konya Training and Research Hospital and 30 healthy controls were included. The presence of 9 different antibodies (IgM and IgG) against Helicobacter pylori, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and parvovirus B19 were investigated in sera samples obtained from the 60 participants using an enzyme-linked immunosorbent assay method. The characteristics of current and past infections with H. pylori, CMV, EBV, and parvovirus B19 were evaluated by determining the seropositivity of the tested bacterial and viral agents. Results:The prevalences of H. pylori, CMV, EBV, and parvovirus B19 were determined to be higher in patients with SSc than in the control group. Conclusion:SSc is associated with a higher rate of certain infections, which deserves further investigation in order to assess the role of infections in disease etiology/pathogenesis.

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A causal role for parvovirus B19 infection in adult dermatomyositis and other autoimmune syndromes

Cited by 91 publications

References 38 publications

Susac's syndrome: 1975–2005 microangiopathy/autoimmune endotheliopathy

Susac's syndrome: 1975–2005 microangiopathy/autoimmune endotheliopathy

Parvovirus B19 DNA Is Commonly Harboured in Human Skin

The prevalence of infectious agents in patients with systemic sclerosis

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