A Cell’s Viscoelasticity Measurement Method Based on the Spheroidization Process of Non-Spherical Shaped Cell

Liu, Yaowei; Zhang, Yujie; Cui, Maosheng; Zhao, Xiangfei; Sun, Mingzhu; Zhao, Xin

doi:10.3390/s21165561

Cited by 3 publications

(2 citation statements)

References 36 publications

(36 reference statements)

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“…However, despite the maturity of existing techniques [ 110 , 117 , 129 , 131 , 132 , 133 , 134 , 135 , 136 , 137 ], most of them measure only mechanical properties of cell membranes or their combinations with cytoskeleton. As a result, the information about mechanical properties of the interior of an individual cell may be difficult to gain.…”

Section: Determining Mechanical Properties Of Cells Bacteria and Biol...mentioning

confidence: 99%

Biomechanical Sensing Using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications

2022

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Gas bubbles present in liquids underpin many natural phenomena and human-developed technologies that improve the quality of life. Since all living organisms are predominantly made of water, they may also contain bubbles—introduced both naturally and artificially—that can serve as biomechanical sensors operating in hard-to-reach places inside a living body and emitting signals that can be detected by common equipment used in ultrasound and photoacoustic imaging procedures. This kind of biosensor is the focus of the present article, where we critically review the emergent sensing technologies based on acoustically driven oscillations of bubbles in liquids and bodily fluids. This review is intended for a broad biosensing community and transdisciplinary researchers translating novel ideas from theory to experiment and then to practice. To this end, all discussions in this review are written in a language that is accessible to non-experts in specific fields of acoustics, fluid dynamics and acousto-optics.

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Section: Determining Mechanical Properties Of Cells Bacteria and Biol...mentioning

confidence: 99%

Biomechanical Sensing Using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications

2022

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“…However, despite technical maturity of a number of current techniques suitable 313 for the investigation of mechanical properties of biological cells[110,117,129,[131][132][133][134][135][136][137], 314 most of these techniques measure those of cell membranes only or of cell membranes 315 combined with cytoskeleton. As a result, the information about mechanical properties of 316 the interior of an individual cell may be difficult to gain.…”

mentioning

confidence: 99%

Biomechanical Sensing using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications

Maksymov¹,

Nguyen²,

Suslov³

2022

Preprint

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Gas bubbles present in liquids underpin many natural phenomena and human-developed technologies that improve the quality of life. Since all living organisms are predominantly made of water, they may also contain gas bubbles—introduced both naturally and artificially—that can serve as biomechanical sensors operating in hard-to-reach places inside a living body and emitting signals that can be detected by common equipment used in ultrasound and photoacoustic imaging procedures. This kind of biosensors is the focus of the present article, where we critically review the emergent sensing technologies based on acoustically driven oscillations of gas bubbles in liquids and bodily fluids. This review is intended for a broad biosensing community and transdisciplinary researchers translating novel ideas from theory to experiment and then to practice. To this end, all discussions in this review are written in a language that is accessible to non-experts in specific fields of acoustics, fluid dynamics and acousto-optics.

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Viscous shaping of the compliant cell nucleus

et al. 2022

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The cell nucleus is commonly considered to be a stiff organelle that mechanically resists changes in shape, and this resistance is thought to limit the ability of cells to migrate through pores or spread on surfaces. Generation of stresses on the cell nucleus during migration and nuclear response to these stresses is fundamental to cell migration and mechano-transduction. In this Perspective, we discuss our previous experimental and computational evidence that supports a dynamic model, in which the soft nucleus is irreversibly shaped by viscous stresses generated by the motion of cell boundaries and transmitted through the intervening cytoskeletal network. While the nucleus is commonly modeled as a stiff elastic body, we review how nuclear shape changes on the timescale of migration can be explained by simple geometric constraints of constant nuclear volume and constant surface area of the nuclear lamina. Because the lamina surface area is in excess of that of a sphere of the same volume, these constraints permit dynamic transitions between a wide range of shapes during spreading and migration. The excess surface area allows the nuclear shape changes to mirror those of the cell with little mechanical resistance. Thus, the nucleus can be easily shaped by the moving cell boundaries over a wide range of shape changes and only becomes stiff to more extreme deformations that would require the lamina to stretch or the volume to compress. This model explains how nuclei can easily flatten on surfaces during cell spreading or elongate as cells move through pores until the lamina smooths out and becomes tense.

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A Cell’s Viscoelasticity Measurement Method Based on the Spheroidization Process of Non-Spherical Shaped Cell

Cited by 3 publications

References 36 publications

Biomechanical Sensing Using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications

Biomechanical Sensing Using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications

Biomechanical Sensing using Gas Bubbles Oscillations in Liquids and Adjacent Technologies: Theory and Practical Applications

Viscous shaping of the compliant cell nucleus

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