A Centennial: Discovery of Paracoccidioides brasiliensis

Soares, Célia Maria de Almeida; Mendes-Giannini, María José Soares; Felipe, Maria Sueli Soares; Chaturvedi, Vishnu

doi:10.1007/s11046-008-9114-3

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Immunization with heat-shock proteins (HSPs) from P . brasiliensis has been shown to provide some degree of protection against experimental disease [ 15 – 17 ]. The most abundant P .…”

Section: Introductionmentioning

confidence: 99%

Saccharomyces cerevisiae Expressing Gp43 Protects Mice against Paracoccidioides brasiliensis Infection

et al. 2015

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The dimorphic fungus Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis (PCM). It is believed that approximately 10 million people are infected with the fungus and approximately 2% will eventually develop the disease. Unlike viral and bacterial diseases, fungal diseases are the ones against which there is no commercially available vaccine. Saccharomyces cerevisiae may be a suitable vehicle for immunization against fungal infections, as they require the stimulation of different arms of the immune response. Here we evaluated the efficacy of immunizing mice against PCM by using S. cerevisiae yeast expressing gp43. When challenged by inoculation of P. brasiliensis yeasts, immunized animals showed a protective profile in three different assays. Their lung parenchyma was significantly preserved, exhibiting fewer granulomas with fewer fungal cells than found in non-immunized mice. Fungal burden was reduced in the lung and spleen of immunized mice, and both organs contained higher levels of IL-12 and IFN-γ compared to those of non-vaccinated mice, a finding that suggests the occurrence of Th1 immunity. Taken together, our results indicate that the recombinant yeast vaccine represents a new strategy to confer protection against PCM.

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“…Immunization with heat-shock proteins (HSPs) from P . brasiliensis has been shown to provide some degree of protection against experimental disease [ 15 – 17 ]. The most abundant P .…”

Section: Introductionmentioning

confidence: 99%

Saccharomyces cerevisiae Expressing Gp43 Protects Mice against Paracoccidioides brasiliensis Infection

et al. 2015

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“…Researchers have focused their efforts in investigating fungal components able to promote cellular immune responses and host protection. Immunization with heat-shock proteins (HSPs) from P. brasiliensis has also been shown to provide some degree of protection against experimental disease (Soares et al, 2008; Ribeiro et al, 2009, 2010). Recently, it was shown that plasmid immunization with a peptide derived from the 43-kDa glycoprotein antigen from the fungus, called P10, was shown to be protective against PCM, inducing a reduction in fungal load in the lungs of experimentally infected mice (Rittner et al, 2012).…”

Section: Immunity To Paracoccidioides Brasiliensis Infectionmentioning

confidence: 99%

ArtinM offers new perspectives in the development of antifungal therapy

Ruas¹,

Carvalho²,

Roque-Barreira³

2012

Front. Microbio.

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The thermally dimorphic fungus Paracoccidioides brasiliensis is the causative agent of paracoccidioidomycosis (PCM), the most frequent systemic mycosis that affects the rural populations in Latin America. Despite significant developments in antifungal chemotherapy, its efficacy remains limited since drug therapy is prolonged and associated with toxic side effects and relapses. In response to these challenges, it is now recognized that several aspects of antifungal immunity can be modulated to better deal with fungal infections. A common idea for halting fungal infections has been the need to activate a cell-based, pro-inflammatory Th1 immune response to improve the fungal elimination. ArtinM, a D-mannose binding lectin from Artocarpus heterophyllus, has the property of modulating immunity against several intracellular pathogens. Here, we review the immunomodulatory activity of ArtinM during experimental PCM in mice. Both prophylactic and therapeutic protocols of ArtinM administration promotes a Th1 immune response balanced by IL-10, which outstandingly reduces the fungal load in organs of the treated mice while maintaining a controlled inflammation at the site of infection. A carbohydrate recognition-based interaction of ArtinM with Toll-like receptor 2 (TLR2) accounts for initiating the immunomodulatory effect of the lectin. The precise identification of the TLR2 N-glycan(s) targeted by ArtinM may support novel basis for the development of antifungal therapy.

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“…In recent years, there have been considerable advances in our understanding of PCM. 27 Future challenges include the need for efficacious therapies of shorter duration with lower risks of developing sequelae and relapse. Poor treatment response and high relapse rates have been associated with depressed cell-mediated immunity.…”

Section: Developments In the Management Of Paracoccidiodomycosismentioning

confidence: 99%

“…In recent years, there have been considerable advances in our understanding of PCM 27 . Future challenges include the need for efficacious therapies of shorter duration with lower risks of developing sequelae and relapse.…”

Section: Developments In the Management Of Paracoccidiodomycosismentioning

confidence: 99%

Advances in paracoccidioidomycosis

Ameen

Talhari

2009

Clinical and Experimental Dermatology

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Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It is becoming globally relevant, as increasing numbers of cases have been detected in returning travellers and immigrants from endemic regions. It is characterized by pulmonary involvement, lymphadenopathy, and chronic progression of mucocutaneous lesions. Untreated, systemic disease can be severe and fatal. Skin features are common and characteristic, enabling the dermatologist to diagnose infection early and prevent the development of serious sequelae. This review outlines the clinical features and management of paracoccidioidomycosis and discusses notable recent developments in molecular diagnosis, prognostics and therapies.

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A Centennial: Discovery of Paracoccidioides brasiliensis

Cited by 7 publications

References 16 publications

Saccharomyces cerevisiae Expressing Gp43 Protects Mice against Paracoccidioides brasiliensis Infection

Saccharomyces cerevisiae Expressing Gp43 Protects Mice against Paracoccidioides brasiliensis Infection

ArtinM offers new perspectives in the development of antifungal therapy

Advances in paracoccidioidomycosis

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