A central control circuit for encoding perceived food value

Crossley, Michael W; Staras, Kevin; Kemenes, György

doi:10.1126/sciadv.aau9180

Cited by 25 publications

(31 citation statements)

References 58 publications

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“…Animals were then immediately placed in a chamber filled with Cu 2+ -free water, which held the animal at the surface of the water. Lymnaea often float on the water’s surface whilst feeding or searching for food, thus this design allowed us to record and analyze changes in their behavior in response to a stimulus in a behaviorally relevant manner 12,13 . Animals were allowed to acclimatize for 10 min in the chamber before a brief (600 ms duration) light off stimulus was presented.…”

Section: Methodsmentioning

confidence: 99%

Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent

et al. 2019

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Interference-based forgetting occurs when new information acquired either before or after a learning event attenuates memory expression (proactive and retroactive interference, respectively). Multiple learning events often occur in rapid succession, leading to competition between consolidating memories. However, it is unknown what factors determine which memory is remembered or forgotten. Here, we challenge the snail, Lymnaea , to acquire two consecutive similar or different memories and identify learning-induced changes in neurons of its well-characterized motor circuits. We show that when new learning takes place during a stable period of the original memory, proactive interference only occurs if the two consolidating memories engage the same circuit mechanisms. If different circuits are used, both memories survive. However, any new learning during a labile period of consolidation promotes retroactive interference and the acquisition of the new memory. Therefore, the effect of interference depends both on the timing of new learning and the underlying neuronal mechanisms.

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Section: Methodsmentioning

confidence: 99%

Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent

et al. 2019

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“…Hunger influences decisions about food-related sensory cues in many animal species. Whereas well-fed individuals can afford to be selective, individuals facing starvation must consider any available source of nutrition (1)(2)(3)(4). Because odors are commonly used to locate and identify food, olfactory responses can likewise vary with feeding state.…”

Section: Introductionmentioning

confidence: 99%

Internal state configures olfactory behavior and early sensory processing in Drosophila larvae

et al. 2021

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Animals exhibit different behavioral responses to the same sensory cue depending on their internal state at a given moment. How and where in the brain are sensory inputs combined with state information to select an appropriate behavior? Here, we investigate how food deprivation affects olfactory behavior in Drosophila larvae. We find that certain odors repel well-fed animals but attract food-deprived animals and that feeding state flexibly alters neural processing in the first olfactory center, the antennal lobe. Hunger differentially modulates two output pathways required for opposing behavioral responses. Upon food deprivation, attraction-mediating uniglomerular projection neurons show elevated odor-evoked activity, whereas an aversion-mediating multiglomerular projection neuron receives odor-evoked inhibition. The switch between these two pathways is regulated by the lone serotonergic neuron in the antennal lobe, CSD. Our findings demonstrate how flexible behaviors can arise from state-dependent circuit dynamics in an early sensory processing center.

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“…An animal makes different decisions about food-related cues when it is hungry versus when it is well fed. Well-fed animals might use cues to be selective about food choices, whereas animals facing starvation might use such cues to find any available food (Wu et al, 2005;Inagaki et al, 2014;Crossley et al, 2018). Olfactory responses are naturally modulated by feeding state, as many animals use odors to identify food.…”

Section: Introductionmentioning

confidence: 99%

Internal state configures olfactory behavior and early sensory processing inDrosophilalarvae

Vogt

Zimmerman

Schlichting

et al. 2020

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Animals can respond differently to a sensory cue when in different states. Here, we show that certain odors repel well-fed Drosophila larvae but attract food-deprived larvae and how feeding state flexibly alters neural processing in an early olfactory circuit, the antennal lobe, to determine the behavioral valence of a sensory cue. Odor valence is assigned by a neuronal architecture that controls a switch between two separate projection neuron output pathways that mediate opposite behavioral responses. A uniglomerular projection neuron pathway mediates odor attraction whereas a multiglomerular projection neuron pathway mediates odor repulsion. The serotonergic CSD neuron in the antennal lobe is a critical regulator of this neuronal and behavioral switch. CSD selects an appropriate behavior by shifting patterns of serotonergic modulation and glutamatergic inhibition onto each output pathway. The antennal lobe is a decision-making circuit for innate behavioral responses that uses feeding state to determine an odor's valence.

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A central control circuit for encoding perceived food value

Abstract: Central dopaminergic neurons encoding hunger state alter the perceived value of a potential food stimulus.

Cited by 25 publications

References 58 publications

Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent

Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent

Internal state configures olfactory behavior and early sensory processing in Drosophila larvae

Internal state configures olfactory behavior and early sensory processing inDrosophilalarvae

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