A central role for TRPS1 in the control of cell cycle and cancer development

Wu, Lixian; Wang, Yuzhi; Liu, Yan; Yu, Shiyi; Xie, Hao; Shi, Xingjuan; Qin, Sheng; Ma, Fei; Tan, Tuan Zea; Thiery, Jean Paul; Chen, Liming

doi:10.18632/oncotarget.2291

Cited by 53 publications

(52 citation statements)

References 79 publications

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“…In sporadic breast cancer, an upregulated TRPS1 expression was previously reported which is in line with our findings in the sporadic subset of control cases . In sporadic breast cancer TRPS1 is linked to the stimulation of cell proliferation and angiogenesis and the promotion of cell cycle progression . Furthermore, TRPS1 overexpression was proposed as a prognostic marker in early stage breast cancer due to an association with improved overall survival and disease‐free survival in these tumors .…”

Section: Discussionsupporting

confidence: 91%

“…Either mutation or deletion of this gene causes a disease called trichorhinophalangeal syndrome. Previous studies have shown that TRPS1 is expressed in several human malignant tumors and implied an important function in tumor growth, cell cycle, angiogenesis, apoptosis, cell proliferation, migration and metastasis …”

mentioning

confidence: 99%

“…Previous studies have shown that TRPS1 is expressed in several human malignant tumors and implied an important function in tumor growth, cell cycle, angiogenesis, apoptosis, cell proliferation, migration and metastasis. [7][8][9][10][11][12][13] In this study, we were able to identify for the first time one miRNA and one of its target proteins to be significantly associated with radiation-associated breast cancer.…”

mentioning

confidence: 99%

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Expression of miRNA‐26b‐5p and its target TRPS1 is associated with radiation exposure in post‐Chernobyl breast cancer

Wilke

Heß

Klymenko

et al. 2017

Intl Journal of Cancer

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Ionizing radiation is a well-recognized risk factor for the development of breast cancer. However, it is unknown whether radiation-specific molecular oncogenic mechanisms exist. We investigated post-Chernobyl breast cancers from radiation-exposed female clean-up workers and nonexposed controls for molecular changes. Radiation-associated alterations identified in the discovery cohort (n = 38) were subsequently validated in a second cohort (n = 39). Increased expression of hsa-miR-26b-5p was associated with radiation exposure in both of the cohorts. Moreover, downregulation of the TRPS1 protein, which is a transcriptional target of hsa-miR-26b-5p, was associated with radiation exposure. As TRPS1 overexpression is common in sporadic breast cancer, its observed downregulation in radiation-associated breast cancer warrants clarification of the specific functional role of TRPS1 in the radiation context. For this purpose, the impact of TRPS1 on the transcriptome was characterized in two radiation-transformed breast cell culture models after siRNA-knockdown. Deregulated genes upon TRPS1 knockdown were associated with DNA-repair, cell cycle, mitosis, cell migration, angiogenesis and EMT pathways. Furthermore, we identified the interaction partners of TRPS1 from the transcriptomic correlation networks derived from gene expression data on radiation-transformed breast cell culture models and sporadic breast cancer tissues provided by the TCGA database. The genes correlating with TRPS1 in the radiation-transformed breast cell lines were primarily linked to DNA damage response and chromosome segregation, while the transcriptional interaction partners in the sporadic breast cancers were mostly associated with apoptosis. Thus, upregulation of hsa-miR-26b-5p and downregulation of TRPS1 in radiation-associated breast cancer tissue samples suggests these molecules representing radiation markers in breast cancer.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Expression of miRNA‐26b‐5p and its target TRPS1 is associated with radiation exposure in post‐Chernobyl breast cancer

Wilke

Heß

Klymenko

et al. 2017

Intl Journal of Cancer

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“…Nonetheless, its role in cancer progression remains largely unknown. Study by Wu et al proposed that TRPS1 acted as a central hub in the control of cell cycle and proliferation during cancer development [35]. Our study found that TRPS1 was significantly high expressed both in BC samples and BC cell lines, and co-expressed with the expression of ERBB2, supporting the critical role of TRPS1 in BC initiation or progression.…”

Section: Discussionsupporting

confidence: 78%

GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancies

et al. 2017

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GATA transcription factors are zinc finger DNA binding proteins that activate transcription during development and cell differentiation. To date, 7 members of GATA family have been reported. However, the expression patterns and the exact roles of distinct GATA family members contributing to tumorigenesis and progression of breast cancer (BC) remain to be elucidated. Here, we studied the expression of GATA transcripts in a variety of tumor types compared with the normal controls using the ONCOMINE and GOBO databases, along with their corresponding expression profiles in an array of cancer cell lines through CCLE analysis. Based on Kaplan-Meier plotter, we further investigated the prognostic values of GATA members specifically high expressed in BC patients. It was found that, when compared with normal tissues, GATA3 and TRPS1 were distinctly high expressed in BC patients among all GATA members. GATA3 expression was significantly associated with ESR1, while TRPS1 was correlated with ERBB2. In survival analysis, GATA3 and TRPS1 mRNA high expressions were correlated to better survival in BC patients, and TRPS1 high expression was significantly associated with longer RFS in patients who have received chemotherapy. These results suggest that GATA3 and TRPS1 are distinct biomarkers and essential prognostic factors for breast cancer.

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“…One of these intergenic palindromes is absent in many tumor samples whereas there are no changes observed in normal samples; other intergenic palindromes got smaller in tumors with no changes in normal samples. TRPS1 gene belongs to the family of transcription factors and may have role in regulating cell proliferation and growth [25]. This gene is localized in chr8q23-24.1, and this region is known to be highly amplified in breast and prostate cancers.…”

Section: Discussionmentioning

confidence: 99%

A pilot study on the prevalence of DNA palindromes in breast cancer genomes

et al. 2016

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BackgroundDNA palindromes are a unique pattern of repeat sequences that are present in the human genome. It consists of a sequence of nucleotides in which the second half is the complement of the first half but appearing in reverse order. These palindromic sequences may have a significant role in DNA replication, transcription and gene regulation processes. They occur frequently in human cancers by clustering at specific locations of the genome that undergo gene amplification and tumorigenesis. Moreover, some studies showed that palindromes are clustered in amplified regions of breast cancer genomes especially in chromosomes (chr) 8 and 11. With the large number of personal genomes and cancer genomes becoming available, it is now possible to study their association to diseases using computational methods. Here, we conducted a pilot study on chromosomes 8 and 11 of cancer genomes to identify computationally the differentially occurring palindromes.MethodsWe processed 69 breast cancer genomes from The Cancer Genome Atlas including serum-normal and tumor genomes, and 1000 Genomes to serve as control group. The Biological Language Modelling Toolkit (BLMT) computes palindromes in whole genomes. We developed a computational pipeline integrating BLMT to compute and compare prevalence of palindromes in personal genomes.ResultsWe carried out a pilot study on chr 8 and chr 11 taking into account single nucleotide polymorphisms, insertions and deletions. Of all the palindromes that showed any variation in cancer genomes, 38% of what were near breast cancer genes happened to be the most differentiated palindromes in tumor (i.e. they ranked among the top 25% by our heuristic measure).ConclusionsThese results will shed light on the prevalence of palindromes in oncogenes and the mutations that are present in the palindromic regions that could contribute to genomic rearrangements, and breast cancer progression.

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A central role for TRPS1 in the control of cell cycle and cancer development

Cited by 53 publications

References 79 publications

Expression of miRNA‐26b‐5p and its target TRPS1 is associated with radiation exposure in post‐Chernobyl breast cancer

Expression of miRNA‐26b‐5p and its target TRPS1 is associated with radiation exposure in post‐Chernobyl breast cancer

GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancies

A pilot study on the prevalence of DNA palindromes in breast cancer genomes

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