A century of research on psychedelics: A scientometric analysis on trends and knowledge maps of hallucinogens, entactogens, entheogens and dissociative drugs

Solmi, Marco; Chen, Chaomei; Daure, Charles; Buot, Anne; Ljuslin, Michael; Verroust, Vincent; Mallet, Luc; Khazaal, Yasser; Rothen, Stéphane; Thorens, Gabriel; Zullino, Daniele; Gobbi, Gabriella; Rosenblat, Joshua D.; Husain, Muhammad Ishrat; Gregorio, Danilo De; Castle, David; Sabé, Michel

doi:10.1016/j.euroneuro.2022.09.004

Cited by 28 publications

(9 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is valuable as a prevalent statistical tool for sorting out the topic structure and evolutionary trends in drug abuse. Solmi et al (2022) conducted a scientometric analysis to outline clinical research on psychedelics over the last century. Zhang et al (2022) reviewed publications on substance abuse and its neurotoxicity through bibliometric ways to deepen the understanding of this progress as well as trends for future research.…”

Section: Introductionmentioning

confidence: 99%

Exploring the topic structure and abuse trends of new psychoactive Substance since the 21st century from a bibliometric perspective

Hou,

Wang,

Zhang

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Exploring the topic structure and abuse trends of new psychoactive Substance since the 21st century from a bibliometric perspective

Hou,

Wang,

Zhang

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

“…Fortunately, scientific studies have continued, helping to dispel many of the myths surrounding these substances. Since the late 1980s, the use of psychedelics in the clinic has seen a renaissance, timid at first and very strong in recent years [ 10 ]. At present, there has been a translational evolution from the bench to the bedside, with phase 2 and 3 trials and/or evidence synthesis in particular.…”

Section: Introductionmentioning

confidence: 99%

Hofmann vs. Paracelsus: Do Psychedelics Defy the Basics of Toxicology?—A Systematic Review of the Main Ergolamines, Simple Tryptamines, and Phenylethylamines

Hernández

Rojas-Hernández

Quintana-Hernández

et al. 2023

Toxics

View full text Add to dashboard Cite

Psychedelics are experiencing a strong renaissance and will soon be incorporated into clinical practice. However, there is uncertainty about how much harm they can cause at what doses. This review aimed to collect information on the health-hazardous doses of psychedelic substances, to be aware of the risks to which patients may be subjected. We focused on ergolamines, simple tryptamines, and phenylethylamines. We reviewed articles published in major medical and scientific databases. Studies reporting toxic or lethal doses in humans and animals were included. We followed PRISMA criteria for revisions. We identified 3032 manuscripts for inclusion. Of these, 33 were ultimately useful and gave relevant information about effects associated with high psychedelics doses. Despite having different molecular structures and different mechanisms of action, psychedelics are effective at very low doses, are not addictive, and are harmful at extremely high doses. For LSD and psilocybin, no dose has been established above which the lives of users are endangered. In contrast, MDMA appears to be the most dangerous substance, although reports are biased by recreational missuses. It seems that it is not only the dose that makes the poison. In the case of psychedelics, the set and setting make the poison.

show abstract

“…After decades of considerable limitation, researchers once again obtained approval to administer psychedelics to humans in 1990 ( Strassman, 1991 , 1995 ), a year which also marks the beginning of a distinct increase in psychedelic publications more broadly ( Solmi et al, 2022 ). Despite this, the first publication for a psychedelic trial in humans during this period did not appear until 1994 ( Hadar et al, 2023 ; Strassman and Qualls, 1994 ), thus marking the beginning of the current “psychedelic renaissance” for the purposes of this review.…”

Section: Introductionmentioning

confidence: 99%

Psilocybin’s effects on cognition and creativity: A scoping review

Bonnieux,

VanderZwaag,

Premji

et al. 2023

J Psychopharmacol

View full text Add to dashboard Cite

Background: Research on psilocybin has become increasingly popular during the current psychedelic renaissance, which began in the early 1990s. Psilocybin’s effects on mental health are promising and there are ongoing efforts to investigate its clinical implementation and its effects on cognition. Aims: The purpose of this study is to report trends in publications, methods, and findings from research examining the effects of psilocybin on cognition and creativity in adults. Methods: We conducted an Open Science Framework preregistered scoping review, guided by the JBI Manual for Evidence Synthesis, on literature pertaining to psilocybin’s effects on cognition and creativity. Results/outcomes: In the 42 included studies, psilocybin was primarily administered orally (83%) in a bodyweight-adjusted manner (74%) to healthy participants (90%). Of the few studies that explicitly reported safety outcomes (26%), only one reported serious adverse reactions. During the acute phase post-intake (i.e., minutes to hours), macrodoses tended to impair cognitive performance and creativity, whereas microdoses tended toward creative enhancement. The few macrodosing studies that included post-acute measures (i.e., 1–85 days) reported primarily null but some positive effects. Conclusions/interpretation: This scoping review identified a time-based variation of psilocybin macrodosing effects on cognition and creativity, in which impairment may be observed early post-intake but withdraw over time, and some positive effects may emerge afterward. These findings are limited by methodological concerns and inadequate assessment of long-term effects. We therefore recommend that future psilocybin research be conducted according to existing guidelines and include well-validated measures of cognition and creativity at multiple timepoints.

show abstract

A century of research on psychedelics: A scientometric analysis on trends and knowledge maps of hallucinogens, entactogens, entheogens and dissociative drugs

Cited by 28 publications

References 109 publications

Exploring the topic structure and abuse trends of new psychoactive Substance since the 21st century from a bibliometric perspective

Exploring the topic structure and abuse trends of new psychoactive Substance since the 21st century from a bibliometric perspective

Hofmann vs. Paracelsus: Do Psychedelics Defy the Basics of Toxicology?—A Systematic Review of the Main Ergolamines, Simple Tryptamines, and Phenylethylamines

Psilocybin’s effects on cognition and creativity: A scoping review

Contact Info

Product

Resources

About