A cerium oxide@metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

Liu, Jintong; Ye, Lin Yao; Wang, Xiong; Liu, Tianrui; Yang, Hong; Lei, Jianping

doi:10.1039/d1cc00001b

Cited by 39 publications

(27 citation statements)

References 31 publications

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“…TEM imaging indicated that CeO 2 @PAA@RGD presented a regular special shape with a uniform distribution and an average diameter of 3.35 ± 0.04 nm ( Figure 1 c), which was lower than the hydrodynamic size, due to the increased hydration layer caused by the PAA and RGD peptide modification on the particle surface. Meanwhile, the UV-Vis spectra showed that the CeO 2 @PAA@RGD had a characteristic absorbance peak similar to the CeO 2 @PAA at around 280 nm ( Figure 1 d), which is consistent with that previous reported by Lei et al [ 48 ]. X-ray photoelectron spectroscopy (XPS) analyses were used to determine the surface Ce 3+ /Ce 4+ ratio on the surface of the CeO 2 @PAA@RGD nanoparticles.…”

Section: Resultssupporting

confidence: 91%

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

Wang

Liu

et al. 2022

Biomolecules

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Although cerium oxide nanoparticles are attracting much attention in the biomedical field due to their unique physicochemical and biological functions, the cerium oxide nanoparticles greatly suffer from several unmet physicochemical challenges, including loss of enzymatic activity during the storage, non-specific cellular uptake, off-target toxicities, etc. Herein, in order to improve the targeting property of cerium oxide nanoparticles, we first modified cerium oxide nanoparticles (CeO2) with polyacrylic acid (PAA) and then conjugated with an endothelium-targeting peptide glycine-arginine-aspartic acid (cRGD) to construct CeO2@PAA@RGD. The physiochemical characterization results showed that the surface modifications did not impact the intrinsic enzymatic properties of CeO2, including catalase-like (CAT) and superoxide dismutase-like (SOD) activities. Moreover, the cellular assay data showed that CeO2@PAA@RGD exhibited a good biocompatibility and a higher cellular uptake due to the presence of RGD targeting peptide on its surface. CeO2@PAA@RGD effectively scavenged reactive oxygen species (ROS) to protect cells from oxidative-stress-induced damage. Additionally, it was found that the CeO2@PAA@RGD converted the phenotype of macrophages from proinflammatory (M1) to anti-inflammatory (M2) phenotype, inhibiting the occurrence of inflammation. Furthermore, the CeO2@PAA@RGD also promoted endothelial cell-mediated migration and angiogenesis. Collectively, our results successfully demonstrate the promising application of CeO2@PAA@RGD in the future biomedical field.

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Section: Resultssupporting

confidence: 91%

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

Wang

Liu

et al. 2022

Biomolecules

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“…[34] The preparation of CeO 2 -Co LDH was straightforward by simply mixing suspensions containing the two components (Figure 1a; Figure S1, Supporting Information). The heterostructure, whose formation is driven by the electrostatic attraction [35,36] between the negatively charged Co LDH (−12.66 mV) and the positively charged CeO 2 (+5.37 mV), is highly stable; its structural integrity was maintained even with repeated washing and ultrasonication.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

CeO₂ Functionalized Cobalt Layered Double Hydroxide for Efficient Catalytic Oxygen‐Evolving Reaction

Zhang

Zheng

2022

Small

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Water splitting to produce hydrogen is an effective means to alleviate the energy crisis. The anodic oxygen‐evolving reaction (OER) limits the overall efficiency due to its high energy barrier. To address this, layered double hydroxides (LDHs) with high catalytic activities have been widely studied, especially those modified with CeO2, either bound to the surface or doped into interior. However, experimental evidence for the atomic‐level understanding of the mechanism for the enhanced catalytic performance is conspicuously missing. Herein, anchoring CeO2 nanoparticles onto Co LDH, based on the thoughts of loading capacity and size effect to regulate the properties of the interface and to optimize the performance, is attempted. The electronic interactions are studied by X‐ray photoelectron spectroscopy (XPS) and electron energy loss spectroscopy (EELS), revealing electron transfer from Co2+ to Ce4+ that leads to an increase in Co3+. The strong Lewis acidity of Co3+ helps the binding of OH−, which is conducive to the formation and transformation of oxygen‐containing intermediates. Providing evidence is the formation of one of the key intermediates Co‐OOH at a sizably reduced potential as monitored by in situ Raman spectroscopy. With this work, the atomic level correlation of site‐specific electronic interactions with the enhanced catalytic performance is clearly established.

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“…The peroxidase-like activity of Fe-based compounds has been studied extensively [36][37][38][39]. The typical peroxidase-like reactions involved were carried out by the following equations:…”

Section: The Mechanism Of Pt/nh 2 -Mil-101 As a Peroxidase Mimetics A...mentioning

confidence: 99%

Pt Nanoparticles Anchored on NH2-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine

Yang

et al. 2021

Chemosensors

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Dopamine (DA) is an important catecholamine neurotransmitter that plays a highly relevant role in regulating the central nervous system, and abnormal DA content can cause many immune-related diseases. Hence, it is of significance to sensitively and specifically identify DA for clinical medicine. In this work, Pt/NH2-MIL-101 hybrid nanozymes with bimetallic catalytic centers were fabricated by forming coordinate bonds between Pt nanoparticles (Pt NPs) and –NH2 on metal–organic frameworks (MOF). The catalytic activity of Pt/NH2-MIL-101 was increased by 1.5 times via enlarging the exposure of more active sites and improving the activity of the active sites through the strategy of forming bimetallic catalytic centers. In the presence of DA, competing with 3, 3′, 5, 5′-tetramethylbenzidine (TMB) for the generated hydroxyl radicals (•OH), the blue oxidation state TMB (Ox-TMB) is reduced to colorless TMB, showing dramatic color changes. The Pt/NH2-MIL-101-based colorimetric assay enables the sensitive and robust detection of DA molecules with a detection limit of only 0.42 μM and has an observable potential in clinical applications.

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A cerium oxide@metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

Abstract: An O2 self-evolving core-shell theranostic nanohybrid was developed by encapsulating the nanoenzyme cerium oxide (CeOx) in the metal-organic framework (MOF). The hybrid revealed a 9-folded apoptotic percentage than bare CeOx...

Cited by 39 publications

References 31 publications

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

CeO₂ Functionalized Cobalt Layered Double Hydroxide for Efficient Catalytic Oxygen‐Evolving Reaction

Pt Nanoparticles Anchored on NH2-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine

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A cerium oxide@metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

Abstract: An O2 self-evolving core-shell theranostic nanohybrid was developed by encapsulating the nanoenzyme cerium oxide (CeOx) in the metal-organic framework (MOF). The hybrid revealed a 9-folded apoptotic percentage than bare CeOx...

Cited by 39 publications

References 31 publications

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

CeO2 Functionalized Cobalt Layered Double Hydroxide for Efficient Catalytic Oxygen‐Evolving Reaction

Pt Nanoparticles Anchored on NH2-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine

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CeO₂ Functionalized Cobalt Layered Double Hydroxide for Efficient Catalytic Oxygen‐Evolving Reaction