A Chemical Hemostatic Technique for Bleeding from Malignant Wounds

Abstract

This simple technique is effective for bleeding from malignant wounds and should be learned by health professionals performing cancer care.

The palliative efficacy of modified Mohs paste for controlling canine and feline malignant skin wounds

“…MPT has been proven effective in terminally ill animals with unresectable skin tumors and tumors that surgical excision is not desired by the animals' owners. In humans, MPT has been documented as an effective treatment to decrease bleeding, decrease frequency of wound dressing changes, decrease odor and degree of pain experienced, and increase patient QOL (Shigeyama et al 2005;Kakimoto et al 2010;Uno et al 2010;Tsukada et al 2012;Komine et al 2014;Nakai et al 2015). Similarly, its efficacy has been demonstrated in this study through significant decreases in tumor size and the number of dressing changes required.…”

“…In veterinary medicine, there is the possibility that animals may accidentally ingest the paste, requiring the animals to be monitored under controlled conditions for MPT. The hemostatic effect for active bleeding has also been obtained by contact of the paste for 10 min (Kakimoto et al 2010). One hour is considered an optimum duration for MPT.…”

“…The preparations of original (Mohs & Guyer 1941) and modified Mohs paste used in this study are described in Table 2. The dosages and formulations of the chemicals and the procedure were based on methods described by Kakimoto et al (2010) and Tukada et al (2012). First, zinc chloride (SigmaAldrich Japan K.K., Tokyo, Japan) and distilled water were placed in a beaker, and then homogenized by stirring.…”

“…Malignant skin wounds which are likely to appear in these patients are an issue which worsens the QOL of the patients. The modified Mohs paste has been applied in patients with malignant skin wounds whose skin tumors are considered unresectable (Shigeyama et al 2005;Kakimoto et al 2010;Uno et al 2010;Tsukada et al 2012;Komine et al 2014;Nakai et al 2015). The application of the Mohs paste had positive effects on the fixed-necrotic tissues, alleviated the signs and symptoms of malignant wounds, and decreased tumor volumes, allowing their subsequent excision (Shigeyama et al 2005;Kakimoto et al 2010;Uno et al 2010;Tsukada et al 2012;Komine et al 2014;Nakai et al 2015).…”

“…The modified Mohs paste has been applied in patients with malignant skin wounds whose skin tumors are considered unresectable (Shigeyama et al 2005;Kakimoto et al 2010;Uno et al 2010;Tsukada et al 2012;Komine et al 2014;Nakai et al 2015). The application of the Mohs paste had positive effects on the fixed-necrotic tissues, alleviated the signs and symptoms of malignant wounds, and decreased tumor volumes, allowing their subsequent excision (Shigeyama et al 2005;Kakimoto et al 2010;Uno et al 2010;Tsukada et al 2012;Komine et al 2014;Nakai et al 2015). The efficacy of modified Mohs paste has been reported in pleomorphic adenoma (Shigeyama et al 2005), adenoid cystic carcinoma (Shigeyama et al 2005), malignant melanoma (Shigeyama et al 2005), and squamous cell carcinoma (SCC) (Komine et al 2014;Nakai et al 2015), and for those with non-cutaneous skin tumors such as angiosarcoma and advanced breast cancer (Shigeyama et al 2005;Kakimoto et al 2010;Uno et al 2010;Tsukada et al 2012).…”