A chemiluminescent light system in combination with toluidine blue to assess suspicious oral lesions—clinical evaluation and review of the literature

BackgroundGold standard for the diagnosis of oral dysplasia (OD) oral squamous cell carcinoma (OSCC) and malignant lesions is the histological examination. Several adjunctive diagnostic techniques have been proposed in order to increase the sensitivity (SE) and specificity (SP) of conventional oral examination and to improve the diagnostic first level accuracy. The aim of this study is to perform a systematic review on non-invasive tools for diagnosis of OD and early OSCC.Material and MethodsMedline, Scopus, Web of Knowledge databases were searched, using as entry terms “oral dysplasia AND diagnosis” / ”oral cancer AND diagnosis”. Data extracted from each study included number of lesions evaluated, histopathological diagnosis, SE, SP, positive and negative predictive values (PPV and NPV), diagnostic accuracy (DA) and the main conclusions.ResultsAfter title and abstract scanning of 11.080 records, we selected 35 articles for full text evaluation. Most evaluated tools were autofluorescence (AF), chemiluminescence (CL), toluidine blu (TL) and chemiluminescence associated with toluidine blue (CLTB).ConclusionsThere is a great inhomogeneity of the reported values and there is no significant evidence of superiority of one tool over the other. Further clinical trials with a higher level of evidence are necessary in order to assess the real usefulness visual diagnostic tools. Key words:Oral dysplasia, oral cancer, diagnosis, visual diagnostic tool, systematic review.

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“…Among 4 studies evaluating CLTB, 3 were perspective (OEBM level: 2b) and 1 was cross-sectional (OEBM level: 2b) ( 7 , 12 , 22 , 35 ).…”

Section: Resultsmentioning

confidence: 99%

Non-invasive visual tools for diagnosis of oral cancer and dysplasia: A systematic review

Giovannacci¹,

Vescovi²,

Manfredi³

et al. 2016

Med Oral

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“…High‐risk sites for dysplasia or carcinoma are floor of the mouth, tongue and lip . A vast variety of adjunct tools including visual [such as toluidine blue staining , fluorescence, chemoluminescence ] as well as cytological techniques [such as brush biopsy , immunologic assays, gene expression analysis ] has been tested to predict malignant transformation rates of precursor lesions such as OL. However, a reliable method with a sensitivity and a specificity close to surgical biopsy has not been found yet .…”

Section: Introductionmentioning

confidence: 99%

Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia

Thiem

Schneider²,

Venkatraman³

et al. 2017

J Oral Pathology Medicine

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“…Thus, early detection of OPMD and oral cancer is critical for the prognosis of diseases [ 5 ]. To date, scalpel biopsy and histopathological examinations are still the standard diagnostic procedures applied to ascertain the oral potentially malignant and malignant lesions [ 17 , 18 ]. However, the biopsy procedure is often invasive, which may cause patients anxiety and discomfort [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, these noninvasive methods still have some limitations [ 12 ]. The visual tools are highly subjective and depend on the expertise of the investigators [ 16 – 18 ]. The main deficiency of exfoliative cytology technology, which is based on the quantitative cytomorphometry and DNA aneuploidy, is the low detection specificity, resulting from the collection of disaggregated cells [ 12 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology: a promising method for oral cancer detection and diagnosis

et al. 2018

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Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques. Nano detection systems are known as new emerging noninvasive strategies that bring the detection sensitivity of biomarkers to nano-scale. Moreover, compared to current imaging contrast agents, nanoparticles are more biocompatible, easier to synthesize, and able to target specific surface molecules. Nanoparticles generate localized surface plasmon resonances at near-infrared wavelengths, providing higher image contrast and resolution. Therefore, using nano-based techniques can help clinicians to detect and better monitor diseases during different phases of oral malignancy. Here, we review the progress of nanotechnology-based methods in oral cancer detection and diagnosis.

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A chemiluminescent light system in combination with toluidine blue to assess suspicious oral lesions—clinical evaluation and review of the literature

Abstract: Clinical evidence to justify the additional cost of the system for diagnosis of suspicious lesions is weak. However, for the potential role of VLP in detection of lesions not otherwise identified in the visual exam in general dental practice further studies are required.

Cited by 23 publications

References 34 publications

Non-invasive visual tools for diagnosis of oral cancer and dysplasia: A systematic review

Non-invasive visual tools for diagnosis of oral cancer and dysplasia: A systematic review

Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia

Nanotechnology: a promising method for oral cancer detection and diagnosis

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