A Chemosensor Array for the Colorimetric Identification of 20 Natural Amino Acids

Buryak, Andrey; Severin, Kay

doi:10.1021/ja042363v

Cited by 238 publications

(133 citation statements)

References 20 publications

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“…The specific interactions involved between the reporter elements and the analyte are noncovalent and reversible. This approach provides an alternative to ''lock-key'' specific recognition (24) and has been used to detect metal ions (25), volatile agents (26), aromatic amines (27), amino acids (28,29), and carbohydrates (25). In recent research we have demonstrated that the displacement of fluorescent polymers from differentially functionalized gold nanoparticles with concomitant restoration of fluorescence provides an effective array-based method for the identification of proteins (30).…”

mentioning

confidence: 99%

Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays

Bajaj¹,

Miranda²,

Kim

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

297

255

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Rapid and effective differentiation between normal and cancer cells is an important challenge for the diagnosis and treatment of tumors. Here, we describe an array-based system for identification of normal and cancer cells based on a ''chemical nose/tongue'' approach that exploits subtle changes in the physicochemical nature of different cell surfaces. Their differential interactions with functionalized nanoparticles are transduced through displacement of a multivalent polymer fluorophore that is quenched when bound to the particle and fluorescent after release. Using this sensing strategy we can rapidly (minutes/seconds) and effectively distinguish (i) different cell types; (ii) normal, cancerous and metastatic human breast cells; and (iii) isogenic normal, cancerous and metastatic murine epithelial cell lines.fluorescence ͉ gold nanoparticle ͉ sensor ͉ conjugated polymer

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mentioning

confidence: 99%

Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays

Bajaj¹,

Miranda²,

Kim

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

297

255

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“…[7][8][9][10] Consequently, their characteristic features provide the potential applications in electrical conductivity, asymmetric synthesis, molecular recognition, liquid crystalline materials for display, and infrared emissivity materials. [11][12][13][14][15] Among the majority of optically active polymers, polyacetylene is very interesting since it is a π-conjugated polymer which possesses a symmetric chain. [16] Polyacetylene and its derivatives possess unique properties such as helix inversion, semi-conductivity, electrical conductivity, and nonlinear optical properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, helicity, thermal stability, and low infrared emissivity of optically active polyacetylenes carrying tyrosine pendants

Chen

Zhou

et al. 2014

Designed Monomers and Polymers

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Optically active polyacetylenes (LPA and DPA) and racemic polyacetylenes (RPA) were prepared by the polymerization of N-propioloyl-tyrosine methyl esters that derived from chiral and racemic tyrosine. All the polymers were characterized by Fourier transform infrared spectroscopy, 1 H NMR, 13 C NMR, gel permeation chromatography, thermogravimetric analysis, UV-vis spectroscopy, and circular dichroism spectroscopy; furthermore, the infrared emissivity values were also investigated. Both LPA and DPA possessed the helical conformations and a higher degree of intra-and interchain hydrogen bonds compared with RPA, which presented irregular polymer chain. The thermal stability of LPA and DPA was higher than that of RPA due to the helical conformations, which could be easy to form a high degree of intra-and interchain hydrogen bonds in the structure. Therefore, LPA and DPA exhibited lower infrared emissivity values (8-14 μm) than that of RPA, which resulted from the helical conformations and a higher degree of intra-and interchain hydrogen bonds.

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“…[15][16][17][18][19][20] Ideally, these systems show a colour change in the presence of the target molecule which is easily detectable with the 'nakedeye'. [21][22][23][24] For cyanide sensing, their mode of action is based on hydrogen bonding, [25,26] bond-forming reactions between either the nucleophilic cyanide and an electrophilic carbon [27][28][29][30][31][32][33][34][35][36] or boron centre [12,[37][38][39] or metal coordination [40][41][42][43] (Scheme 1). Progress is observed for all of these different systems, but a sensor that meets all of following three criteria has not yet been synthesized: i) optical detection below the maximum permissible level of cyanide in drinking water (1.7 μM); ii) demonstrating a fast and unambiguous response in pure water (<5 sec) without the need for special reaction conditions or sample pre-treatment; iii) displaying high selectivity in the presence of other anions.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Colorimetric Detection of Cyanide

Zelder¹,

Männel-Croisé²

2009

Chimia

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This short-review discusses the recent developments in the colorimetric detection of cyanide with different types of receptors. Significant progress in terms of selectivity, sensitivity and straightforwardness has been observed for either organic-, main group- or transition metal-based sensors. Our group has developed a simple and highly specific system for the optical sensing of cyanide based on the conformational switch of commercially available vitamin B12.

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A Chemosensor Array for the Colorimetric Identification of 20 Natural Amino Acids

Cited by 238 publications

References 20 publications

Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays

Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays

Synthesis, helicity, thermal stability, and low infrared emissivity of optically active polyacetylenes carrying tyrosine pendants

Recent Advances in the Colorimetric Detection of Cyanide

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