A chemotaxonomic study of nine Canarian Sideritis species

Sideritis spp.: Uses, chemical composition and pharmacological activities—A review

“…Twenty-five Sideritis species grow in Morocco, 16 of which are endemic (Ghoumari et al, 2005). Iberian Peninsula and Baleares Islands contain 49 Sideritis species, 36 of them being endemic; in the Canary Islands, this genus is represented by 19 endemic species (Fraga et al, 2009;Morales, 2000Morales, , 2010.…”

“…The monocyclic sesquiterpene dehydrovomifoliol has recently been isolated from Sideritis argosphacelus var. spicata (Fraga et al, 2009). …”

Trachylobane and kaurane diterpenes from Croton floribundus spreng

“…1 These compounds have been largely cited as cytotoxic, antitumoral, genotoxic, antiinflammatory, antibacterial, antifungal and moluscidal. [2][3][4] On the other hand, trachylobane is found in some species of Euphorbiaceae, 5 Annonaceae, 6 Asteraceae, 7 Lamiaceae 8 and Leguminosae. 9 Although the biological activities of trachylobane compounds are poorly investigated, they are cited to possess vasorelaxant and cytotoxic properties.…”

“…The cytotoxicity of the compounds 1, 3, 4, 6-11 against a small panel of cancer cell lines was evaluated ( Figure 1). (1)(2)(3)(4)(5)(6)(7) and chemical derivatives of compound 1 (8)(9)(10)(11) were attributed to two oxymethylene groups attached to a quaternary carbon. In addition, the presence of the shielded doublets at d 0.58 (d, J = 7.5 Hz, H-12) and 0.83 (dd, J = 7.5 and 2.4 Hz, H-13) of a tetrasubstituted cyclopropane ring suggested that 1 belongs to the trachylobane series.…”

“…ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8)(9)(10)(11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated.…”