A child presenting with hypercalcemia

Çelik, Emre; Özdemir, Nihal; Tüysüz, Gülen; Taştan, Yücel; Çam, Halit; Çelkan, Tiraje

doi:10.5152/tpa.2014.661

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Pamidronate is the most frequently used of the bisphosphonates [7]. Although previous cases [8,9] imply that hypercalcemia is usually treated with pamidronate, calcium levels gradually decreased to normal levels within five days with intravenous fluid therapy, furosemide, and steroids in our case.…”

Section: Casementioning

confidence: 60%

Mature B Cell Acute Lymphoblastic Leukemia Presenting with Hypercalcemia

Balcı¹

2015

J Leuk

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Section: Casementioning

confidence: 60%

Mature B Cell Acute Lymphoblastic Leukemia Presenting with Hypercalcemia

Balcı¹

2015

J Leuk

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“…The main factors is the osteolytic PTH-related protein (PTHrP) [ 3 ]. ALL presenting with hypercalcaemia has a distinctive clinical profile, and most of the reported cases show certain common characteristics [ 6 - 8 ]. It is observed in most children concerned similar characteristics such as older age (10-20 years), normal or low white blood cell (WBC) counts with rare or absent circulating blasts on peripheral blood smear.…”

Section: Discussionmentioning

confidence: 99%

“…It is observed in most children concerned similar characteristics such as older age (10-20 years), normal or low white blood cell (WBC) counts with rare or absent circulating blasts on peripheral blood smear. The blasts characteristically show a pre-B ALL phenotype with aberrant expression of CD13 and other myeloid antigens and often are positive for t(17;19) on cytogenetic studies [ 6 - 8 ]. In our observation all these characteristics are present apart from age, our patient was young and del(12) (p13) on cytogenetic studies.…”

Section: Discussionmentioning

confidence: 99%

“…In our observation all these characteristics are present apart from age, our patient was young and del(12) (p13) on cytogenetic studies. Another common accompanying finding in ALL patients presenting with hypercalcemia is disseminated osteolytic lesions [ 8 ]. In our patient, osteolytic lesions were found interestingly multiple osteolytic lesions were seen in the skull, humerus, pelvic bone, both femurs, and both tibias.…”

Section: Discussionmentioning

confidence: 99%

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Osteolytic bone lesions, severe hypercalcemia without circulating blasts: unusual presentation of childhood acute lymphoblastic leukemia

et al. 2017

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Hypercalcemia and severe osteolytic lesions are rare complications of acute lymphoblastic leukemia (ALL) in childhood. We report a case of a 3 years old boy who presented with prolonged fever, nausea, vomiting and increasing lower limbs pain. Skeletal X-rays and CT scan showed severe osteolytic lesions of the skull and extremities. Her physical examination showed multiple cervical lymph nodes. In laboratory tests, he had severe hypercalcemia. Parathyroid hormone (PTH) was not elevated. Despite the absence of circulating blasts, bone marrow biopsy revealed B-precursor (ALL). Hypercalcemia was initially treated with intravenous isotonic sodium chloride solution and diuretics but the serum calcium level normalized only after the beginning of corticosteroids and chemotherapy. The child responded initially to chemotherapy and eventually relapsed and died of septic shock. Acute leukemia must be considered in differential diagnosis in patients with hypercalcemia. A detailed examination even when there no circulating blasts in their peripheral blood smear, and if in doubt bone marrow aspiration should must be taken into consideration.

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Hypercalcemia: a consultant’s approach

Auron

Alon

2017

Pediatr Nephrol

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Due to their daily involvement in mineral metabolism, nephrologists are often asked to consult on children with hypercalcemia. This might become even more pertinent when the hypercalcemia is associated with acute kidney injury and/or hypercalciuria and renal calcifications. The best way to assess the severity of hypercalcemia is by measurement of plasma ionized calcium, and if not available by adjusting serum total calcium to albumin concentration. The differential diagnosis of the possible etiologies of the disturbance in the mineral homeostasis starts with the assessment of serum parathyroid hormone concentration, followed by that of vitamin D metabolites in search of both genetic and acquired etiologies. Several tools are available to acutely treat hypercalcemia with the current main components being fluids, loop diuretics, and antiresorptive agents. This review will address the pathophysiologic mechanisms, clinical manifestations, and treatment modalities involved in hypercalcemia.

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A child presenting with hypercalcemia

Cited by 7 publications

References 18 publications

Mature B Cell Acute Lymphoblastic Leukemia Presenting with Hypercalcemia

Mature B Cell Acute Lymphoblastic Leukemia Presenting with Hypercalcemia

Osteolytic bone lesions, severe hypercalcemia without circulating blasts: unusual presentation of childhood acute lymphoblastic leukemia

Hypercalcemia: a consultant’s approach

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