A chip-integrated optical microfluidic pressure sensor

Hoera, Christian; Kiontke, Andreas; Pahl, Maik; Belder, Detlev

doi:10.1016/j.snb.2017.08.195

Cited by 32 publications

(19 citation statements)

References 50 publications

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“…It is also relevant to develop integrated systems that are able to validate and measure the generated flow inside microfluidic networks, as well as being able to determine backpressure. A simple system, based on luminescent optical sensors, as presented by Hoera et al (2017), is an attractive possibility (Hoera et al, 2017) and enables the simultaneous measurement of temperature and oxygen concentration. -Mixing/dilution unit: Mixing is an extremely important function when performing reactions or studying the influence of certain compounds, since it needs to occur faster than the reaction effect being studied in order not to significantly influence the outcome (Liau et al, 2005).…”

Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

“Connecting worlds – a view on microfluidics for a wider application”

Fernandes

Gernaey

Krühne

2018

Biotechnology Advances

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From its birth, microfluidics has been referenced as a revolutionary technology and the solution to long standing technological and sociological issues, such as detection of dilute compounds and personalized healthcare. Microfluidics has for example been envisioned as: (1) being capable of miniaturizing industrial production plants, thereby increasing their automation and operational safety at low cost; (2) being able to identify rare diseases by running bioanalytics directly on the patient's skin; (3) allowing health diagnostics in point-of-care sites through cheap lab-on-a-chip devices. However, the current state of microfluidics, although technologically advanced, has so far failed to reach the originally promised widespread use. In this paper, some of the aspects are identified and discussed that have prevented microfluidics from reaching its full potential, especially in the chemical engineering and biotechnology fields, focusing mainly on the specialization on a single target of most microfluidic devices and offering a perspective on the alternate, multi-use, "plug and play" approach. Increasing the flexibility of microfluidic platforms, by increasing their compatibility with different substrates, reactions and operation conditions, and other microfluidic systems is indeed of surmount importance and current academic and industrial approaches to modular microfluidics are presented. Furthermore, two views on the commercialization of plug-and-play microfluidics systems, leading towards improved acceptance and more widespread use, are introduced. A brief review of the main materials and fabrication strategies used in these fields, is also presented. Finally, a step-wise guide towards the development of microfluidic systems is introduced with special focus on the integration of sensors in microfluidics. The proposed guidelines are then applied for the development of two different example platforms, and to three examples taken from literature. With this work, we aim to provide an interesting perspective on the field of microfluidics when applied to chemical engineering and biotechnology studies, as well as to contribute with potential solutions to some of its current challenges.

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Section: Available Unit Operations In Microfluidic Chipsmentioning

confidence: 99%

“Connecting worlds – a view on microfluidics for a wider application”

Fernandes

Gernaey

Krühne

2018

Biotechnology Advances

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“…Alternatively, the deflection of a beam from pressure‐induced deformation of channel walls can be measured . Pressure‐sensitive paints can be used, too . These approaches contain high potential for local pressure measurement, particularly combined with local microcontroller.…”

Section: Integrated Sensorsmentioning

confidence: 99%

Smart Equipment – A Perspective Paper

Kockmann

Bittorf

Krieger

et al. 2018

Chemie Ingenieur Technik

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Chemical equipment has to form a robust and efficient process space and was developed over the last centuries to very sophisticated, often highly specialized devices. With the upcoming information technology new opportunities arise with integrated sensors, and advanced control systems. Smart equipment is designed in form of intelligent modules. Furthermore, adaptive and integrated actuators convert the control signals to directly influence the process, thus, they can be described as responsive equipment. This contribution will give an overview of some activities in this field.

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“…However, due to the limited range of microchannel dimensions, it is very difficult to integrate an additional pressure-sensing functionality without disturbing the flow field [ 25 , 26 , 27 ]. Therefore, measuring pressure inside microchannels is challenging and novel methods are demanded [ 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several methods have been proposed in the literature for pressure measurement inside microchannels [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. The majority of these published approaches are mechanical in nature and primarily use a membrane that deflects as a function of the applied pressure [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Easy Method for Pressure Measurement in Microchannels Using Trapped Air Compression in a One-End-Sealed Capillary

Shen

et al. 2020

Micromachines

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Pressure is one basic parameter involved in microfluidic systems. In this study, we developed an easy capillary-based method for measuring fluid pressure at one or multiple locations in a microchannel. The principal component is a commonly used capillary (inner diameter of 400 μm and 95 mm in length), with one end sealed and calibrated scales on it. By reading the height (h) of an air-liquid interface, the pressure can be measured directly from a table, which is calculated using the ideal gas law. Many factors that affect the relationship between the trapped air volume and applied pressure (papplied) have been investigated in detail, including the surface tension, liquid gravity, air solubility in water, temperature variation, and capillary diameters. Based on the evaluation of the experimental and simulation results of the pressure, combined with theoretical analysis, a resolution of about 1 kPa within a full-scale range of 101.6–178 kPa was obtained. A pressure drop (Δp) as low as 0.25 kPa was obtained in an operating range from 0.5 kPa to 12 kPa. Compared with other novel, microstructure-based methods, this method does not require microfabrication and additional equipment. Finally, we use this method to reasonably analyze the nonlinearity of the flow–pressure drop relationship caused by channel deformation. In the future, this one-end-sealed capillary could be used for pressure measurement as easily as a clinical thermometer in various microfluidic applications.

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A chip-integrated optical microfluidic pressure sensor

Cited by 32 publications

References 50 publications

“Connecting worlds – a view on microfluidics for a wider application”

“Connecting worlds – a view on microfluidics for a wider application”

Smart Equipment – A Perspective Paper

An Easy Method for Pressure Measurement in Microchannels Using Trapped Air Compression in a One-End-Sealed Capillary

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