A Chlorotoxin‐Directed Diselenide‐Bridged Tumor‐Homing Persistent Luminescence Nanoprobes Mediating Inhibition of Oxidative Phosphorylation for Long‐Term Near‐Infrared Imaging and Therapy of Glioblastoma (Adv. Funct. Mater. 1/2023)

Kong, Jianglong; Sun, Yuting; Ge, Xiaohan; Mao, Meiru; Yu, Hongrui; Wang, Yi

doi:10.1002/adfm.202370008

Cited by 6 publications

(5 citation statements)

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“…Table 2 depicts some strategies using diselenide‐based compounds combined with nanoformulations to potentiate anticancer effects, directing drug delivery, and the main outcomes. Diorganyl diselenides have potentiated their anticancer effects when incorporated into nanocapsules (inside or coating them) as anti‐glioma treatment, being suitable for intravenous administration, [326] as nanoprobes, [327] cross‐linked with carboxymethyl chitosan [328] and also, contributing to the suppression of tumor growth [329–331] . Yang and coworkers illustrated that employing diselenide‐bridged mesoporous silica nanoparticles (MSNs) for light‐responsive degradation and dual drug release results in synergistic anti‐tumor and minimal adverse off‐target effects [332] .…”

Section: Pharmacology Of Diorganyl Diselenidesmentioning

confidence: 99%

Recent Progress in Synthetic and Biological Application of Diorganyl Diselenides

do Carmo Pinheiro,

Souza Marques,

Ten Kathen Jung

et al. 2024

The Chemical Record

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Diorganyl diselenides have emerged as privileged structures because they are easy to prepare, have distinct reactivity, and have broad biological activity. They have also been used in the synthesis of natural products as an electrophile in the organoselenylation of aromatic systems and peptides, reductions of alkenes, and nucleophilic substitution. This review summarizes the advancements in methods for the transformations promoted by diorganyl diselenides in the main functions of organic chemistry. Parallel, it will also describe the main findings on pharmacology and toxicology of diorganyl diselenides, emphasizing anti‐inflammatory, hypoglycemic, chemotherapeutic, and antimicrobial activities. Therefore, an examination detailing the reactivity and biological characteristics of diorganyl diselenides provides valuable insights for academic researchers and industrial professionals.

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Section: Pharmacology Of Diorganyl Diselenidesmentioning

confidence: 99%

Recent Progress in Synthetic and Biological Application of Diorganyl Diselenides

do Carmo Pinheiro,

Souza Marques,

Ten Kathen Jung

et al. 2024

The Chemical Record

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“…ZnGa 2 O 4 as classical host has been reported for persistent NIR fluorescence imaging. [ 78 ] For instance, Kong et al. prepared ZnGa 2 O 4 :Cr 3+ , Sn 4+ (ZGO) with 695 nm persistent luminescence under UV light irradiation.…”

Section: Nir Light Responsive Materials For Imaging Diagnosis Of Brai...mentioning

confidence: 99%

Advances of NIR Light Responsive Materials for Diagnosis and Treatment of Brain Diseases

Xue

Wang

Zhang

2023

Advanced Optical Materials

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Generally, brain diseases could be classified into various types. [2] The first is brain tumors, such as malignant glioblastoma, which grows invasively and destroys deep structures. The second type is brain trauma, i.e., traumatic brain injury (TBI), [3] which could cause multiple secondary injuries, including neuroinflammation, blood brain barrier (BBB) damage, and brain edema. The brain vascular diseases are an important type of brain diseases, such as strokes, which can induce a range of dysfunction due to the severe damage to the motor and sensory central nervous system (CNS). Besides, neurodegenerative diseases such as Alzheimer's disease (AD) can result in an irreversible damage to brain tissues owing to the loss of neurons and myelin sheath over time. However, due to the unclear pathogenesis and the obstacle of BBB in CNS, precise imaging diagnosis and effective therapy of brain diseases still remain a great challenge till now. [4] Hence, it is an urgent need to develop the noninvasive, efficient, and convenient techniques for precise imaging and effective therapy of brain diseases. In recent years, the optical materials have attracted great attention in the field of bioapplications, [5] but the limited penetration depth of common used excitation lights (ultraviolet or visible lights, UV-Vis) leads to their applications only in some superficial diseases, such as skin or oral tumors. [6] Currently, it has been reported that the near infrared (NIR) lights exhibit much deeper tissue penetration depth than that of UV-Vis lights, [7] especially penetrate the skull, which makes them possible for imaging and therapy of brain diseases. Hence, exploring NIR light responsive materials is a promising way for achieving precise diagnosis and efficient therapy of brain diseases. [8,9] In terms of imaging, photoacoustic (PA) imaging and the fluorescence imaging are the major imaging techniques responding to NIR lights. PA imaging integrates the advantages of NIR light and ultrasound, achieving biological imaging with deep tissue penetration depth (≈6 cm) and high contrast and resolution. [10] Besides, the lower scattering and autofluorescence of tissues in NIR region endow NIR fluorescence imaging with high sensitivity and signal-to-noise ratio (SNR). [11,12] Indocyanine green (ICG), a NIR molecule dye, was used as NIR fluorescence imaging probe in 1955 and approved by Food and Drug Administration (FDA) for clinic in 1959, but it suffered from the poor photostability and short blood circulation.

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“…[ 136,137 ] For example, the fluorescence of some persistent luminescence nanoprobes can last for several minutes to hours, making them valuable for monitoring the tumor size and long‐term imaging with significantly improved sensitivity. [ 138–140 ] Several diagnostic and therapeutic NPs have been developed based on the strong luminescence of metal nanoclusters (MNCs) in combination with multiple treatment methods, which have promising development prospects in cancer therapeutic evaluation. [ 141,142 ] In addition to strong luminescence, MNCs have the ability to produce ROS and photothermal effects under excited light, thereby showing PDT capacity.…”

Section: Luminescence Nanoprobe‐mediated Therapeutic Evaluationsmentioning

confidence: 99%

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

Guo

et al. 2023

Advanced Sensor Research

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Luminescence nanoprobes have been extensively investigated for many biomedical applications, ranging from cell/tissue imaging, real‐time monitoring pathophysiological changes, drug discovery, bioassays, image‐guided surgery, and therapeutic evaluations, mainly due to their excellent physicochemical properties such as tailorable size, controlled morphology, and regulatable luminescence performances. In particular, rationally designed luminescence nanoprobes with reasonable functional integration enable pharmacological effect‐based drug screening, quantification of biological/pharmaceutical agents, and monitoring therapeutic responses of different drugs. This review provides an overview of the applications of different types of luminescence nanoprobes in drug discovery and development, involving various nanoprobes for high‐throughput and high‐content drug screening, pharmaceutical analysis, and therapeutic evaluations in cancers, cardiovascular diseases, and other typical inflammatory diseases. Moreover, challenges and future perspectives regarding future applications of luminescence nanoprobes in the drug discovery field are also discussed.

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A Chlorotoxin‐Directed Diselenide‐Bridged Tumor‐Homing Persistent Luminescence Nanoprobes Mediating Inhibition of Oxidative Phosphorylation for Long‐Term Near‐Infrared Imaging and Therapy of Glioblastoma (Adv. Funct. Mater. 1/2023)

Cited by 6 publications

References 0 publications

Recent Progress in Synthetic and Biological Application of Diorganyl Diselenides

Recent Progress in Synthetic and Biological Application of Diorganyl Diselenides

Advances of NIR Light Responsive Materials for Diagnosis and Treatment of Brain Diseases

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

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