A cholinergic modulator

Torda, Clara

doi:10.1007/bf01918819

Cited by 4 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier, Hamilton in his studies of the effect of diazepam (Hamilton 1967) and flurazepam (Hamilton & Stone 1982) on the in-vitro rat phrenic nerve-hemidiaphragm preparation, also observed this biphasic effect. The mechanism underlying this biphasic pattern of the concentration-response curve is still unclear, but Torda & Gage (1977) and Torda & Murphy (1979) showed that diazepam not only reduced the duration of the end-plate currents and hence the amplitude of the postsynaptic potentials in the mouse hemidiaphragm, but also acts presynaptically where it increases the quantal content of the end-plate potential in the mouse sternomastoid nerve muscle preparation. Torda and his colleagues suggested that this increase in quantal content is likely to mask some of the postsynaptic depression of the amplitude of the end-plate potential by diazepam.…”

Section: Benzodiazepines and Muscle Relaxationmentioning

confidence: 99%

Effect of some benzodiazepines on peripheral neuromuscular function in the rat in-vitro hemidiaphragm preparation

Driessen

Vree

Booij

et al. 1984

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

The effect of equimolar cumulative concentrations of 11 different benzodiazepines on the indirectly evoked twitch contraction was investigated in the rat in-vitro phrenic nerve-hemidiaphragm preparation. Depending on the pattern of the concentration-response curves two groups of benzodiazepines can be distinguished: (i) a first group with a biphasic action, e.g. potentiation of twitch tension in low concentrations and depression of twitch tension in high concentrations, and (ii) a second group with primary depression of twitch tension with increasing concentrations. All of the tested compounds ultimately caused a 100% depression of twitch tension at concentrations ranging from 0.175 to 0.35 mmol litre-1. Although this peripheral effect of benzodiazepines on neuromuscular function is not the main site of action of these compounds, there are enough arguments to state that it is not a simple toxic effect. There is some evidence from this study that the peripheral component of the benzodiazepine effect on muscle relaxation may involve a multi- rather than one single receptor system.

show abstract

Section: Benzodiazepines and Muscle Relaxationmentioning

confidence: 99%