A chronic model for evaluating the itching associated with allergic conjunctivitis in rats

Minami, Kazuhiko; Kamei, Chiaki

doi:10.1016/j.intimp.2003.10.013

Cited by 37 publications

(27 citation statements)

References 18 publications

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“…Additionally, we observed that IgE level in the DNCB group was significantly higher than that in mice in the control group and administration of β-sitosterol suppressed the increased IgE levels in serum. In pathological skin conditions, histamine is involved in the induction of itching and edema (Minami and Kamei, 2004). This study focused on the manner in which β-sitosterol regulates the scratching behaviors in mice.…”

Section: Discussionmentioning

confidence: 99%

The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice

Kim

2017

BSL

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β-sitosterol, one of phytosterols, exhibited numerous pharmacological effect including anti-inflammatory, anti-cancer and immune-modulating properties. This study attempted to determine the pharmacological effects of β-sitosterol on atopic dermatitis (AD). We investigated to ascertain the pharmacological effects of β-sitosterol on 2, 4-dinitrochlrobenzene (DNCB)-induced AD symptom and histamine-induced scratching behaviors in mice. Additionally, we evaluated the effects of β-sitosterol on the interleukin (IL)-6 levels in HaCaT cells and skin tissue of AD. The findings of this study demonstrated that β-sitosterol reduced AD clinical symptoms such as eczematous, erythema and dryness and serum histamine and IgE levels in DNCB-induced AD model and histamine-induced scratching behaviors in mice. Additionally, β-sitosterol inhibited the IL-6 expression in AD-like skin lesion and HaCaT cells. Collectively, these findings provide that β-sitosterol could be a therapeutic agent for skin inflammation including AD.

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Section: Discussionmentioning

confidence: 99%

The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice

Kim

2017

BSL

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“…In severe allergic conjunctivitis, a late phase reaction occurs with stimulation of secondary mediators causing further mast cell degranulation and lymphocyte infiltration (Leonardi et al, 1990;Abelson et al, 1994;Donshik and Ehlers, 1994). In rats, egg albumin-induced edema and mast cell degranulation was reported to mimic closely human ocular conjunctivitis which is associated with vascular permeability and release of histamine from mast cells (Calonge et al, 1990;Minami and Kamei, 2004). Increase in vascular permeability is mainly due to histamine action and an increase in vascular permeability is generated by the contraction of endothelial cells after the binding of histamine H1 receptors located in these cells (Togias, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore it is aimed to study the effect of these two herbs against antigen-induced conjunctivitis in rats in allergic rat conjunctivitis models viz. vascular permeability of the conjunctiva, histamine release from the conjunctiva, histamine content in tears and histopathological examination (Minami and Kamei, 2004). The results were compared with topically active H1 anti-histamine azelastine hydrochloride as positive control (Ciprandi et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumin-induced experimental allergic conjunctivitis in rats

Zalawadia¹,

Chintan²,

Vaibhav³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYAllergic conjunctivitis is the most common allergic disease. These diseases are severe & frequent which requires search of new treatments. The aim of the study was to investigate the effects of Tinospora cordifolia (TC), Rubia cordifolia Linn. (RC) on experimentally induced allergic conjunctivitis in rats. In this study, dried water soluble extracts of TC and RC. (250 and 500 mg/kg, p.o. for 7 days) were evaluated for their antiallergic activity in Wistar rats. They were tested for inhibition of egg albumin-induced vascular permeability, inhibition of histamine release from the rat conjunctiva as well as in histamine content in tears. TC and RC showed significant (P < 0.05) inhibition in vascular permeability, inhibition in histamine release from the rat conjunctiva which is reflected by reduced level of histamine content in tears. The activities were found to be comparable to azelastine hydrochloride. These results suggest that the inhibitory effect on egg albumin-induced experimental allergic conjunctivitis in rat may be due to the antihistaminic activity of TC and RC. Our studies provide evidence that TC and RC may be beneficial in the treatment of allergic conjunctivitis.

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“…Its receptor has been associated with AD 40) . To investigate the effect of TJ on the mRNA expression of IL-4, real-time PCR was performed.…”

Section: Il-4 Promotes Differentiation Of Th2 Cells Andmentioning

confidence: 99%

Effects of Torilis japonica Extract on DNCB-induced Contact Dermatitis in BALB/c Mice

Lee¹,

Song²,

Hong³

2016

The Journal of Korean Medicine Ophthalmology and Otolaryngology

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A chronic model for evaluating the itching associated with allergic conjunctivitis in rats

Cited by 37 publications

References 18 publications

The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice

The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice

Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumin-induced experimental allergic conjunctivitis in rats

Effects of Torilis japonica Extract on DNCB-induced Contact Dermatitis in BALB/c Mice

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A chronic model for evaluating the itching associated with allergic conjunctivitis in rats

Cited by 37 publications

References 18 publications

The Ameliorative Effect of &beta;-sitosterol on DNCB-induced Atopic Dermatitis in Mice

The Ameliorative Effect of &beta;-sitosterol on DNCB-induced Atopic Dermatitis in Mice

Inhibitory effects of Tinospora cordifolia and Rubia cordifolia Linn. on egg albumin-induced experimental allergic conjunctivitis in rats

Effects of Torilis japonica Extract on DNCB-induced Contact Dermatitis in BALB/c Mice

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The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice

The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice