A circadian rhythm in lipid mobilization which is altered in IDDM

Hagström-Toft, E; Bolinder, Jan; Ungerstedt, Urban; Arner, Peter

doi:10.1007/s001250050789

Cited by 54 publications

(35 citation statements)

References 43 publications

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“…Lipolysis was evaluated by means of plasma FFA level. Nocturnal rises were seen in both groups, in line with earlier findings in healthy subjects (Hagstrom-Toft et al, 1997;Meyer et al, 2003). As long as the fast continued, FFA level inclined to reach a maximum of 1.0 and 1.2 mmol/l for the sensitive and the resistant group, respectively.…”

Section: Effects Of Fasting On Hypoglycemic Young Adults J Alkén Et Alsupporting

confidence: 90%

Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals

2007

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Background and Objectives: Among otherwise healthy adults, there is a subgroup of individuals who develop symptoms of hypoglycemia during episodes of food restriction. The aim of the present study was to investigate whether such individuals develop hypoglycemia or react abnormally in other metabolic aspects during a 24-hour fast. Subjects and Methods: Ninety medical students were asked if they wanted to participate. Sixteen were selected; none dropped out. A 24-hour fast was performed at a hospital ward. Blood samples and questionnaires were taken at eight specific times. Result: During the fast, the sensitive group reported significantly higher scores on 'irritation' and 'shakiness'. However, no hypoglycemia occurred and the lowest detected blood glucose concentration was 3.7 mmol/l. There were no differences between the groups in plasma glucose, cortisol, growth hormone (GH), insulin, b-hydroxybutyrate (b-OH) and lactate levels. The blood pressures and heart rates were also similar. Conclusions: Adults, despite subjective signs of hypoglycemia, can fast without any metabolic or endocrine derangement.

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Section: Effects Of Fasting On Hypoglycemic Young Adults J Alkén Et Alsupporting

confidence: 90%

Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals

2007

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“…The present observation of low circulating levels of fatty acids and glycerol in fasted T825T subjects further supports the role of G␤ 3 in regulating lipolysis in man. We have previously shown that fasting circulating levels of glycerol and free fatty acids measured in the morning closely mirror the rate of lipolysis in subcutaneous adipose tissue (24).…”

Section: Discussionmentioning

confidence: 92%

Effect of the (C825T) Gβ3 Polymorphism on Adrenoceptor-Mediated Lipolysis in Human Fat Cells

Rydén

Faulds²,

Hoffstedt³

et al. 2002

Diabetes

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A common G␤ 3 gene polymorphism (C825T) influences G protein receptor-mediated signal transduction. We investigated whether this polymorphism influences lipolysis in isolated subcutaneous fat cells from 114 healthy obese subjects. The G␤ 3 protein content was markedly decreased in adipocytes of TT carriers, but the alternatively spliced short form of G␤ 3 previously shown in platelets of 825T carriers was not detected. Fat cells of TT carriers showed a significant 10-fold decrease in the half-maximum effective concentration of agonists selective for lipolytic ␤ 1 -and ␤ 2 -adrenoceptors as well as for the antilipolytic ␣ 2 A-adrenoceptor. In TT carriers, maximum ␤-adrenoceptor agonist-stimulated lipolysis was decreased, but the maximum antilipolytic effect of ␣ 2 -adrenoceptors was less marked. Norepinephrine induced adipocyte lipolysis and circulating fasting levels of free fatty acids and glycerol were reduced by half in TT carriers. The polymorphism did not influence the adipocyte content of ␣ 2 A-adrenoceptors, ␤ 2 -adrenoceptors, G␣ i , or G␣ s . In conclusion, the C825T variant of G␤ 3 influences lipolysis. Adipocytes of TT carriers have a lower G␤ 3 protein content and a decreased function of native G s -as well as G i -coupled adrenoceptors, which reduces the lipolytic effect of catecholamines. These data differ from those obtained in other cell systems that have shown increased expression of an alternative spliced G␤ 3 variant and enhanced G protein signaling in 825T carriers, indicating that the polymorphism has cell type؊specific effects that may be of importance for type 2 diabetes and other insulinresistant conditions.

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“…Only the Gly16Gly/Glu27Glu diplotype was associated with a lower fasting FFA concentration in female overweight subjects, which may possibly reflect a reduced rate of lipolysis in subcutaneous adipose tissue. 47 Finally, literature suggests that the Thr164Ile b 2 -adrenoceptor polymorphism is closely associated with Gly at position 16 and Gln at position 27. 39,48 Nevertheless, due to the relatively low sample size, we were not able to identify b 2 -adrenoceptor haplotypes for codons 16, 27 and 164 with a frequency 45%.…”

Section: Discussionmentioning

confidence: 99%

Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

et al. 2006

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Background and aims: Obesity is associated with a blunted b-adrenoceptor-mediated lipolysis and fat oxidation. We investigated whether polymorphisms in codon 16, 27 and 164 of the b 2 -adrenoceptor gene (ADRB2) and exon 10 of the G protein b 3 -subunit gene (GNB3) are associated with alterations in in vivo lipolysis and fat oxidation. Design and methods: Sixty-five male and 43 female overweight and obese subjects (body mass index (BMI) range: 26.1-48.4 kg/m 2 ) were included. Energy expenditure (EE), respiratory quotient (RQ), circulating free fatty acid (FFA) and glycerol levels were determined after stepwise infusion of increasing doses of the non-selective b-agonist isoprenaline (ISO). Results: In women, the Arg16 allele of the ADRB2 gene was associated with a blunted increase in circulating FFA, glycerol and a decreased fat oxidation during ISO stimulation. In men, the Arg16 allele was significantly associated with a blunted increase in FFA but not in glycerol or fat oxidation. Conclusion: These results suggest that genetic variation in the ADRB2 gene is associated with disturbances in in vivo b-adrenoceptor-mediated lipolysis and fat oxidation during b-adrenergic stimulation in overweight and obese subjects; these effects are influenced by gene-gender interactions.

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A circadian rhythm in lipid mobilization which is altered in IDDM

Cited by 54 publications

References 43 publications

Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals

Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals

Effect of the (C825T) Gβ3 Polymorphism on Adrenoceptor-Mediated Lipolysis in Human Fat Cells

Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

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