A class of water-soluble Fe(iii) coordination complexes as T₁-weighted MRI contrast agents

Abstract

Iron-based coordination complexes are showing increasing potentials to be alternatives for T1-weighted magnetic resonance imaging (MRI) and contribute to the safety to the gadolinium-based compounds. In this work, three water-soluble...

An iron-chelating sulfonamide identified from Drosophila-based screening for antipathogenic discovery

“…After fabrication, the 4a -iron complexes were subjected to IR and UV-visible (UV-Vis) spectroscopy. As shown in Figure 3a the formation of iron chelation was verified by a strong stretching vibrational band at about 592 cm −1 ( 7a ) and 591 cm −1 ( 7b ) in the IR spectra, as the hall mark of the Fe-O bond formation [ 31 ]. Moreover, the absorption bands near 486 nm in the UV-Vis absorption spectra of 7a and 7b could be associated with a change in electronic distribution due to d-d transition (Figure S4) [ 31 ].…”

Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents

“…Changing the coordination groups and/or introducing suitable hydrophilic groups of the previously studied chelators (for example, HBED, EHPG, and TACN) can largely alter the coordination structures of the central iron ions (with or without inner-sphere water ligand), the second coordination sphere environment, as well as the charge of the complexes, which gives rise to the enhance of relaxivities and the improvement of thermodynamic stability. Clinically used iron-sequestering agents with a high biocompatibility and strong binding ability to Fe 3+ could be also a good [68] 1.07 b 1.28 b --MOC-Fe(III) 4 [68] 1.…”

“…The recently independent studies from our group [ 68 , 69 ] and the group of Janet R Morrow [ 70 ] demonstrated that water soluble metal–organic cages (MOC) with multiple Fe(III) centers are promising alternatives to prepare multinuclear Fe(III) complexes [ 71 ]. In our study, two water soluble metal-organic cages with two (MOC-Fe(III) 2 ) and four Fe(III) centers (MOC–Fe(III) 4 ) based on the bisbidentate catecholate ligand were prepared ( Figure 11 ) [ 68 ].…”

“…The recently independent studies from our group [ 68 , 69 ] and the group of Janet R Morrow [ 70 ] demonstrated that water soluble metal–organic cages (MOC) with multiple Fe(III) centers are promising alternatives to prepare multinuclear Fe(III) complexes [ 71 ]. In our study, two water soluble metal-organic cages with two (MOC-Fe(III) 2 ) and four Fe(III) centers (MOC–Fe(III) 4 ) based on the bisbidentate catecholate ligand were prepared ( Figure 11 ) [ 68 ]. The dinuclear triple helicate configuration of MOC-Fe(III) 2 as well as the tetrahedral configuration of MOC–Fe(III) 4 was confirmed by the quadrupole time-of-flight mass spectrometry (Q-TOF-MS), UV-Vis spectroscopy, and IR spectroscopy.…”

“… ( a ) Chemical structures of the metal–organic cages with two (MOC–Fe(III) 2 ) and four Fe(III) centers (MOC–Fe(III) 4 ), ( b ) relaxivities of MOC–Fe(III) 4 in solution and the corresponding MRI images, and ( c ) in vivo magnetic resonance images of BALB/c mice with 4T1 tumors before and after intratumor injection of MOC–Fe(III) 4. [ 68 ]. Reprinted/adapted with permission from Ref.…”