A claustrum in reptiles and its role in slow-wave sleep

Norimoto, Hiroaki; Fenk, Lorenz A.; Li, Hsing-Hsi; Tosches, Maria Antonietta; Gallego-Flores, Tatiana; Hain, David; Reiter, Sam; Kobayashi, Riho; Macias, Angeles; Arends, Anja; Klinkmann, Michaela; Laurent, Gilles

doi:10.1038/s41586-020-1993-6

Cited by 152 publications

(181 citation statements)

References 57 publications

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“…6c,d). This finding confirms that the medial aDVR in lizards is the claustrum homologue, as suggested by electrophysiological characterization, axonal tracing and single-cell RNAseq [36], [43].…”

Section: Strp-seq Data Allows For the Analysis Of Regional Identitiessupporting

confidence: 87%

Spatial tissue profiling by imaging-free molecular tomography

Schede

Schneider

Stergiadou

et al. 2020

Preprint

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Genomics techniques are currently being adapted to provide spatially resolved omics profiling. However, the adaptation of each new method typically requires the setup of specific detection strategies or specialized instrumentation. A generic approach to spatially resolve different types of high throughput data is missing. Here, we describe an imaging-free framework to localize high throughput readouts within a tissue by combining compressive sampling and image reconstruction. We implemented this framework to transform a low-input RNA sequencing protocol into an imaging-free spatial transcriptomics technique (STRP-seq) and validated this method with a transcriptome profiling of the murine brain. To verify the broad applicability of STRP-seq, we applied the technique on the brain of the Australian bearded dragon Pogona vitticeps. Our results reveal the molecular anatomy of the telencephalon of this lizard, providing evidence for a marked regionalization of the reptilian pallium and subpallium. Overall, the proposed framework constitutes a new approach that allows upgrading in a generic fashion conventional genomic assays to spatially resolved techniques.

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Section: Strp-seq Data Allows For the Analysis Of Regional Identitiessupporting

confidence: 87%

Spatial tissue profiling by imaging-free molecular tomography

Schede

Schneider

Stergiadou

et al. 2020

Preprint

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“…These results suggest a common developmental origin of claustrum neurons and deep layer cortical neurons from agranular insular, somatosensory, and temporal cortex. In a transcriptomic study of the highly connected DVR of reptiles, Norimoto et al (2020) discovered that it expresses markers characteristic of the mouse claustrum and was subsequently proposed as the reptilian claustral homolog. Interestingly, the next most closely related structure to the reptilian DVR is the dorsal lateral amygdala, a structure whose homolog in mice, the basolateral amygdala, was noted to be of similar developmental origin to the mouse claustrum by Puelles et al (2000) and Molnár and Butler (2002).…”

Section: Introductionmentioning

confidence: 99%

In search of common developmental and evolutionary origin of the claustrum and subplate

Bruguier

Suárez

Manger

et al. 2020

J of Comparative Neurology

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The human claustrum, a major hub of widespread neocortical connections, is a thin, bilateral sheet of gray matter located between the insular cortex and the striatum. The subplate is a largely transient cortical structure that contains some of the earliest generated neurons of the cerebral cortex and has important developmental functions to establish intra-and extracortical connections. In human and macaque some subplate cells undergo regulated cell death, but some remain as interstitial white matter cells. In mouse and rat brains a compact layer is formed, Layer 6b, and it remains underneath the cortex, adjacent to the white matter. Whether Layer 6b in rodents is homologous to primate subplate or interstitial white matter cells is still debated. Gene expression patterns, such as those of Nurr1/Nr4a2, have suggested that the rodent subplate and the persistent subplate cells in Layer 6b and the claustrum might have similar origins. Moreover, the birthdates of the claustrum and Layer 6b are similarly precocious in mice. These observations prompted our speculations on the common developmental and evolutionary origin of the claustrum and the subplate. Here we systematically compare the currently available data on cytoarchitecture, evolutionary origin, gene expression, cell types, birthdates, neurogenesis, lineage and migration, circuit connectivity, and cell death of the neurons that contribute to the claustrum and subplate. Based on their similarities and differences we propose a partially common early evolutionary origin of the cells that become claustrum and subplate, a likely scenario that is shared in these cell populations across all amniotes.

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“…To our knowledge, however, none of these processes have been demonstrated in vertebrate brain evolution at cell type resolution. Doing so requires a comprehensive comparison of cell types across regions (Yao et al 2020) and species (Hodge et al 2019;Bakken et al 2020;Boldog et al 2018;Hodge et al 2020;Tosches et al 2018;Krienen et al 2019;Peng et al 2019;Hoang et al 2019;Norimoto et al 2020;Khrameeva et al 2020) in a system that contains different numbers of homologous regions in different species.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set

Ringach

Richman

Friedmann

et al. 2020

Preprint

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How have complex brains evolved from simple circuits? Here we investigated brain region evolution at cell type resolution in the cerebellar nuclei (CN), the output structures of the cerebellum. Using singlenucleus RNA sequencing in mice, chickens, and humans, as well as STARmap spatial transcriptomic analysis and whole-CNS projection tracing in mice, we identified a conserved cell type set containing two classes of region-specific excitatory neurons and three classes of region-invariant inhibitory neurons. This set constitutes an archetypal CN that was repeatedly duplicated to form new regions. Interestingly, the excitatory cell class that preferentially funnels information to lateral frontal cortices in mice becomes predominant in the massively expanded human Lateral CN. Our data provide the first characterization of CN transcriptomic cell types in three species and suggest a model of brain region evolution by duplication and divergence of entire cell type sets.

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A claustrum in reptiles and its role in slow-wave sleep

Cited by 152 publications

References 57 publications

Spatial tissue profiling by imaging-free molecular tomography

Spatial tissue profiling by imaging-free molecular tomography

In search of common developmental and evolutionary origin of the claustrum and subplate

Cerebellar nuclei evolved by repeatedly duplicating a conserved cell type set

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