A clean synthesis of 2,5-dihydro-1H-pyrrole-2-carboxylates under catalyst-free and solvent-free conditions: cytotoxicity and molecular docking studies

Solvent‐Free Synthesis of Pyrroles: An Overview

“…A green approach towards the synthesis of 2,5‐dihydro‐1H‐pyrrole‐2‐carboxylates via a one‐pot reaction of ethyl pyruvate and aniline derivatives was established under solvent‐ and catalyst‐free conditions by Niknam et al [83] . Molecular docking studies and cytotoxicity activities of the above molecules were also investigated effectively.…”

“…A green approach towards the synthesis of 2,5-dihydro-1Hpyrrole-2-carboxylates via a one-pot reaction of ethyl pyruvate and aniline derivatives was established under solvent-and catalyst-free conditions by Niknam et al [83] Molecular docking studies and cytotoxicity activities of the above molecules were also investigated effectively. Using the synthesized anilinebearing sulfonamides and aniline derivatives, they optimized the reaction conditions to get the maximum yield of target pyrrole-2-carboxylate compounds, which was finally established at 80 °C under solvent-free conditions (Scheme 26).…”

Schiff base Mo(vi) complexes grafted on Merrifield resin as recyclable and efficient catalysts for the synthesis of pyrrole-2-ones

“…They exist widely as building blocks in natural products and various synthetic compounds. 4 Pyrrole-2-one derivatives have many important biological activities, such as antimicrobial, 5 anticancer, 6 anti-inflammatory, 7 antimalarial 8 and anti-insecticidal. 9 In addition, pyrrolidone is an important precursor of bioactive compounds in organic synthesis, providing important synthetic opportunities for the synthesis of biological and pharmaceutical compounds.…”