A clerodane diterpene from Polyalthia longifolia as a modifying agent of the resistance of methicillin resistant Staphylococcus aureus

Gupta, Vivek Kumar; Tiwari, Nimisha; Gupta, Priyanka; Verma, S. C.; Pal, Anirban; Srivastava, Santosh K.; Darokar, Mahendra P.

doi:10.1016/j.phymed.2016.03.001

Cited by 44 publications

(30 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides sesquiterpenes, diterpenes also function as a good antibiotic enhancer against MRSA. Moreover, diterpenes have been widely used in combination therapy with antibiotics [82]. For instance, clerodane diterpenoid 16αhydroxycleroda-3, 13 (14)-Z-dien-15, 16-olide (CD) extracted from leaves of Polyathia longifolia enhanced the efficacy of oxacillin, tetracycline, daptomycin, and linezolid against clinical isolates of MRSA.…”

Section: Terpenes and Their Derivativesmentioning

confidence: 99%

“…All MICs of the antibiotic dropped significantly between 10–80, 4–16, 2–8 and 2–4-folds respectively when combined with CD. Gupta et al [82] then proposed the in vivo mechanism of CD in reversing the resistance of clinical isolates of MRSA. The same clinical MRSA isolates were tested with CD combined with norfloxacin, ciprofloxacin, and ofloxacin.…”

Section: Terpenes and Their Derivativesmentioning

confidence: 99%

See 1 more Smart Citation

Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens

et al. 2019

View full text Add to dashboard Cite

The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives comprising of hydrocarbons, are usually found in essential oils (EOs). They have been reported to have potent antimicrobial activity, exhibiting bacteriostatic and bactericidal effects against tested pathogens. This brief review discusses the activity of terpenes and derivatives against pathogenic bacteria, describing the potential of the activity against AMR followed by the possible mechanism exerted by each terpene class. Finally, ongoing research and possible improvisation to the usage of terpenes and terpenoids in therapeutic practice against AMR are discussed.

show abstract

Section: Terpenes and Their Derivativesmentioning

confidence: 99%

Section: Terpenes and Their Derivativesmentioning

confidence: 99%

Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The bactericidal non-microbial natural products are derived from various sources including, plants, insects, animals, and fungi. These natural compounds have been reported to target and act on multiple bacterial targets such as cell wall [62,63], pyruvate kinase [64], cell division [65], DNA topoisomerase [66], and efflux pump [67,68]. These pharmacological targets are further discussed in Section 4.…”

Section: Potent Natural Products Against Drug-resistant S Aureusmentioning

confidence: 99%

“…For examples, Wang and colleagues showed that genistein killed the MRSA by inhibiting NorA efflux protein when used in combination with drugs [134]. Mechanistic studies have also shown that various bactericidal natural compounds such as coumarin derivatives [68], linoleic and oleic acids [144], clerodane diterpene [67], and Anadenanthera colubrina (Cebil/Vilca) [150] acted on MRSA's efflux pump or proteins.…”

Section: Efflux Pumpmentioning

confidence: 99%

Non-microbial Natural Products That Inhibit Drug-Resistant Staphylococcus aureus

Chew¹,

Peh²,

Yeang³

2019

Staphylococcus Aureus

View full text Add to dashboard Cite

Drug resistance developed in human pathogenic bacteria is emerging and has become a global problem. Methicillin-resistant Staphylococcus aureus (MRSA) spreading in both hospital and community areas has posed a great impact to global public health. Current antibiotics used against these resistant strains are no longer efficacious and the search for new alternative is in urgent need. In the past decades, natural products have demonstrated multiple biological activities in biomedical areas including their antibacterial actions against various drug-resistant bacteria. More promisingly, some natural products could reverse the resistance of bacteria to the antibiotics, making the target bacteria susceptible to these drugs again. Numerous natural products have also exhibited potent synergism against the drug-resistant bacteria when used in combination with various types of antibiotics. Recently, several antibacterials derived from microbes have been developed and approved by Food and Drug Administration (FDA) for clinical use. In this chapter, we discuss the potential use of non-microbial natural products in controlling Staphylococcus aureus (S. aureus)'s growth, and the underlying challenges in developing the natural products into clinical applications.

show abstract

“…6 The terpenoid classes are the predominant special metabolite constituents of this genus, and the clerodane diterpenes, the prevalent type of Croton. 3,[7][8][9][10] Several clerodane diterpenes isolated from different species had been tested for their biological activities, and presented potentially useful medicinal properties, such as antimicrobial, [11][12][13][14] anti-inflammatory, 15,16 antiprotozoal, [17][18][19][20][21] and antitumoral. [22][23][24][25][26] The trans-dehydrocrotonin (1) is a nor-clerodane diterpene isolated from Croton cajucara as major component.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of New trans-Dehydrocrotonin Nitrogenated Derivatives and their Cytotoxic and DNA-Topoisomerase I Inhibitory Activities

Esteves-Souza¹,

Pissinate²,

Maciel³

et al. 2017

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

A new series of 19-nor-clerodane diterpene derivatives was synthesized from the natural trans-dehydrocrotonin obtained from stem barks of Croton cajucara (Euphorbiaceae), a native medicinal plant of the Brazilian Amazon. The new derivatives were obtained by changes in the ketone moiety of trans-dehydrocrotonin leading to nitrogenated derivatives which are: three substituted hydrazine diterpenes, oxime, and methyloxime. The cytotoxic effect of the diterpene derivatives was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against Ehrlich carcinoma and K562 human leukemia cells. The cytotoxic activity of the hydrazine and oxime semi-synthetic derivatives was better than the one of the natural product trans-dehydrocrotonin. Moreover, all diterpenes were tested for their DNA topoisomerase I inhibitory activity, and the most effective one, in general, was observed to the phenyl-hydrazone derivative. Results indicated that the topoisomerase I inhibitory effect is correlated with the cytotoxic activity.

show abstract

A clerodane diterpene from Polyalthia longifolia as a modifying agent of the resistance of methicillin resistant Staphylococcus aureus

Cited by 44 publications

References 29 publications

Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens

Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens

Non-microbial Natural Products That Inhibit Drug-Resistant Staphylococcus aureus

Synthesis of New trans-Dehydrocrotonin Nitrogenated Derivatives and their Cytotoxic and DNA-Topoisomerase I Inhibitory Activities

Contact Info

Product

Resources

About