A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids

Nakayama, Tetsuo; Aizawa, Chikara; Kuno-Sakai, Harumi

doi:10.1016/s0091-6749(99)70508-7

Cited by 108 publications

(70 citation statements)

References 7 publications

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“…It has greatly simplified the volume of immunization activities by decreasing the number of injections, amount of pain and cumulative exposure to preservatives and stabilizers that may contribute to adverse events. 1,2 Diphtheria (D), pertussis (P), tetanus (T) and Haemophilus influenzae type b (Hib) are common infectious diseases which can lead to serious morbidity and also mortality in pediatric age…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian children

Sharma¹,

Yadav²,

Lalwani³

et al. 2011

Human Vaccines

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Section: Introductionmentioning

confidence: 99%

Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian children

Sharma¹,

Yadav²,

Lalwani³

et al. 2011

Human Vaccines

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“…In the same study, 15 patients who had a severe reaction to eggs were also vaccinated, and no reaction was observed after vaccination (20). In literature, children without egg allergy were observed to have anaphylactic reactions depending on measles, MMR, and chickenpox vaccination, and mostly, the gelatin in the vaccines was considered responsible (26). An intradermal test was not performed in our patients because of the risk of anaphylaxis in the test itself in addition to the difficulty in application compared to the skin prick test (invasive), the difficulty in obtaining approval from the family, and the false positivity rate of up to 15% (27).…”

Section: Discussionmentioning

confidence: 98%

“…In 366 children who had reaction to 0.2% gelatin-containing MMR vaccination, Nakayama et al (26) found anaphylaxis in 34, urticarial rash in 76, non-urticarial rash in 215, and local reaction in 41 children. The IgE antibody against gelatin was examined in the serum of 206 cases.…”

Section: Discussionmentioning

confidence: 99%

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

Özdemir¹,

Ersavas²

2017

JAREM

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Objective: Egg allergy is the second most common food allergy in infants and may cause urticaria, angioedema, anaphylaxis, and exacerbation of atopic dermatitis. Egg allergy is diagnosed by carefully examining a patient's clinical history, performing contributory skin prick tests, and assessing specific IgE levels to hen's egg. The administration of measles, measles-mumps-rubella (MMR), and varicella vaccinations to children with egg allergy remains controversial. These vaccines contain trace amounts of egg proteins as they are produced in chicken embryo fibroblast cultures. The incidence of anaphylaxis as a result of vaccinations is very low, and its cause (egg or gelatin) is not well known. Here we report our experience with the three vaccinations in 18 patients with egg allergy (34 dose).Methods: Between 2013 and 2016, we retrospectively evaluated patients with egg allergy who presented to our allergy clinic for vaccinations. After performing the skin prick test for patients who were admitted to our clinic, vaccinations were administered by dividing the doses in equal two parts.Results: All patients had a clinical history, and atopic dermatitis coexisted with egg allergy in three patients. The skin prick test results were positive in 12 (67%) patients. The specific IgE test was positive in 16 (89%) patients. There was a reaction in just one (2.9%) patient of 18 patients of 34 dose vaccinations.Conclusion: Measles, MMR, and varicella vaccinations in children with egg allergy were found to be safe albeit small number of patients. We believe that egg allergy does not necessitate a delay or contraindication for vaccination.

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“…These rates may seem higher as the adverse events seem to mimic the sum total of adverse event rates for each individual antigen used [35][36][37] but may even have lower rates [11]. However, the reduction in amount of vaccine preparations will lead to decrease in cumulative exposure to stabilizers and preservatives contained in vaccines [35,38], a benefit well worth considering.…”

Section: Safety and Adverse Eventsmentioning

confidence: 99%

Combination vaccines in the South African setting

Visser

Hoosen

2012

Vaccine

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Abstract:The number of vaccines available and included as part of the national immunization schedules, has increased significantly over the past few decades. This impacts on patient/parent compliance and creates a challenge for health care providers for implementation of schedules necessitating training and infrastructure improvements. Use of combination rather than component vaccines offers advantages for compliance by single dose administration of various antigens, reducing stock costing as well as reducing cost of additional health care visits. Combination vaccines are often significantly more expensive than individual constituent vaccines.

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A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids

Cited by 108 publications

References 7 publications

Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian children

Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian children

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

Combination vaccines in the South African setting

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