A clinical and electrophysiological study of a family with hereditary optic neuropathy

Salu, P; Ceulemans, Lisa; Deconinck, H.; Claeskens, W.; Trau, R

doi:10.3109/13816818509006130

Cited by 1 publication

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In high-altitude regions, residents, in particular, newborns face a significant health peril in the form of HIE, owing to reduce atmospheric pressure and other associated factors 3 . While various medications can mitigate intracranial pressure and alleviate patient symptoms, the treatment outcomes for neuronal damage caused by HIE remain unsatisfactory 4 . Consequently, there is an urgent need for effective interventions to address this condition.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Chen,

Song,

Song

et al. 2023

Commun Biol

View full text Add to dashboard Cite

Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective treatment. Acer truncatum Bunge Seed extract (ASO) is reported to have effect on cognitive improvement, but its molecular mechanisms on HIE are unclear. In this study, ASO administration contributed to reduced neuronal cell edema and improved motor ability in HIE rats at a simulated 4500-meter altitude. Transcriptomics and WGCNA analysis showed genes associated with lipid biosynthesis, redox homeostasis, neuronal growth, and synaptic plasticity regulated in the ASO group. Targeted and untargeted-lipidomics revealed decreased free fatty acids and increased phospholipids with favorable ω-3/ω-6/ω-9 fatty acid ratios, as well as reduced oxidized glycerophospholipids (OxGPs) in the ASO group. Combining multi-omics analysis demonstrated FA to FA-CoA, phospholipids metabolism, and lipid peroxidation were regulated by ASO treatment. Our results illuminated preliminary metabolism mechanism of ASO ingesting in rats, implying ASO administration as potential intervention strategy for HIE under high-altitude.

show abstract

Section: Introductionmentioning

confidence: 99%