A clinical evaluation of asthma control test to assess the control of asthma and its relation to the severity of asthma

Patil, Bhagyashri; Eti, Ajith; Lolly, Mitchelle; Khan, Shehtaj; Bansal, Anupma

doi:10.4103/ijhas.ijhas_84_16

Cited by 1 publication

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“…Patients were recruited from the out-patient clinic at the Department of Respiratory Diseases, AL -Imamain Al-Kadhumain Teaching Hospital in Baghdad. They were prescribed with a maintenance inhaled corticosteroid treatment and remained uncontrolled with an Asthma Control Test (ACT) <16 [9].…”

Section: Methodsmentioning

confidence: 99%

Immunocytochemical assessment of FKBP51 and Glucocorticoid receptor localization in asthmatic patients

Alsaffar

Yenzeel

Ghazi

2019

eijs

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Asthma is a chronic inflammatory disease affecting 5% of the world population. FKBP51 is an important immunophilin modular protein of the glucocorticoid receptor (GC). The aim of the present study was to evaluate the levels and immunocytochemical distribution of FKBP51 and GR in lymphocyte cells of asthmatic patients, by use of immunocytochemistry method, and to assesslevels ofstress hormones (cortisol and ACTH) by radioimmuniassay (RIA). The results showed significantly increased nuclear localization and decreasedcytoplasmic distribution of FKBP51, while they showed a significant increase in nuclear localization and a non-significant decrease in cytoplasmic distribution of GRin asthmatic patients(P<0.05). Cortisol and ACTH levels were also measured and showedinsignificant increases(P<0.05)in steroid treated (338.85 Â±139.5 mMol/L, 35.05Â±3.77 ng/ml, respectively)and non steroid treated asthmatics(280.5 Â± 74.6 mMol/L, 32.0Â±6.43 ng/ml, respectively)as compared with the control group (234.33Â±29.13 mMol/L, 29.0Â±7.02 ng/ml, respectively).

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Section: Methodsmentioning

confidence: 99%