A clinical evaluation of the maximal histalog test

Goldenberg, Julio; Cummins, Alvin J.; Gompertz, Michael L.

doi:10.1007/bf02233179

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1969

2011

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Cited by 12 publications

(2 citation statements)

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“…An analogue of histamine called Betazole (Histalog), which had a lower incidence of side effects has also been used at a dose of 2 mg ⁄ kg. 10,22,23 However, with the introduction of pentagastrin in the late 1960s, the use of histamine and its analogue declined. 24 Pentagastrin is a derivative of gastrin and is a synthetic polypeptide containing the five Carbon-terminal amino acid sequence of gastrin.…”

Section: Invasive Methodsmentioning

confidence: 99%

Review article: methods of measuring gastric acid secretion

Ghosh

Lewis

Axon

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

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Section: Invasive Methodsmentioning

confidence: 99%

Review article: methods of measuring gastric acid secretion

Ghosh

Lewis

Axon

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

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“…Only small and insignificant changes were seen in diastolic blood pressure. This is a considerable advantage over hista mine or betazole, where the most hazardous side effect is hypotension with shock [2,5]. The incidence of other side effects such as headache and mild skin erythema at the site of injection was low.…”

Section: Discussionmentioning

confidence: 88%

Clinical Experience with Impromidine, a Highly Specific H<sub>2</sub>-Receptor Agonist

Bangerter¹,

Schlup²,

Liechti³

et al. 1981

Digestion

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The gastric secretory response to impromidine (SKF 92676), a potent selective histamine H₂ agonist, has been studied in 40 patients with peptic ulcer disease or ulcer-like dyspepsia. Peak acid output following the intravenous infusion of impromidine, 10 μg kg^-1·h^-1, or pentagastrin, 6 μg kg^-1h^-1, was not significantly different. This was also the case when the two drugs were administered subcutaneously at the same dose. Impromidine was well tolerated with only minor effects on the cardiovascular system both in 10 younger patients and in 20 subjects over the age of 55 years with mild to moderate cardiovascular disease. Impromidine can be considered an important tool for further investigation of the role of histamine at the H₂-receptor site in man.

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