A clinical study of renal tubular dysfunction in<i>Cleistanthus collinus</i>(Oduvanthalai) poisoning

Nampoothiri, Keshavan; Chrispal, Anugrah; Begum, Anisa; Jasmine, Sudha; Gopal, Gopinath Kango; Zachariah, Anand

doi:10.3109/15563651003641786

Cited by 23 publications

(37 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The usual causes of death are respiratory failure requiring ventilator support and cardiac arrhythmia48. In the present study, 37.5 per cent mortality was observed which was higher than that observed in earlier reports148910. This difference may be because of older age and delayed presentation to hospital in the present study.…”

Section: Discussioncontrasting

confidence: 63%

“…In the present study, the patients were older when compared with the patients seen at Vellore, India89. Consumption of C. collinus was found equal among women and men (male:female=1.1:1) in the present study while in other studies a female preponderance was observed.…”

Section: Discussioncontrasting

confidence: 52%

“…Consumption of C. collinus was found equal among women and men (male:female=1.1:1) in the present study while in other studies a female preponderance was observed. Metabolic acidosis, the most common clinical manifestation in two earlier reports from Puducherry (21.7%)1 and Vellore (100%)9 was only observed in 32 per cent of patients in the current study. Hypokalemia (58%) was the most common clinical feature in our patients which was similar to the figure documented in earlier reports810.…”

Section: Discussioncontrasting

confidence: 44%

“…There are only a few published human studies148910 available on C. collinus poisoning. However, in these studies severity of illness scoring systems was not used.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cleistanthus collinus poisoning

Naik

Harikrishna

Kumar

et al. 2016

Indian Journal of Medical Research

View full text Add to dashboard Cite

Background & objectives:Ingestion of Cleistanthus collinus causes hypokalemia and cardiac arrhythmias leading to mortality in most cases. We undertook this retrospective study to evaluate the clinical presentation and predictors of outcome in critically ill patients admitted with C. collinus poisoning.Methods:The case records of 56 patients admitted to the medical intensive care unit (MICU) of a tertiary care teaching hospital in south India (2000-2014) with C. collinus poisoning were retrospectively analysed.Results:The mean age of patients was 36.7±13.3 yr; there were 30 males. Salient clinical manifestations included hypokalemia (58%), neutrophilic leucocytosis (48.2%), acute kidney injury (AKI) (42.9%), acute respiratory failure requiring mechanical ventilation (AcRFMv) (32.1%), shock (21.4%); cardiac arrhythmias and neuromuscular weakness (19.6% each); 21 patients (37.5%) had adverse outcome. Longer time-lapsed from consumption to reaching emergency room [median (interquartile range)] (hours) [49 (22-97) vs. 28 (7-56), P=0.038]; higher acute physiology and chronic health evaluation II (APACHE II) score at presentation [14 (8.25-14.75) vs. 2 (0-6) P<0.001]; and presence of the following [odds ratio (95% confidence intervals)] at initial presentation: shock [37.40 (4.29-325.98), P=0.001]; AcRFMv [26.67 (5.86-121.39), P<0.001]; elevated alanine aminotransferase [5.71 (1.30-25.03), P=0.021]; metabolic acidosis [5.48 (1.68-17.89), P=0.005]; acute kidney injury (AKI) [5 (1.55-16.06), P=0.007]; hyponatremia [4.67 (1.25-17.44), P=0.022]; and neutrophilic leucocytosis [3.80 (1.02-14.21), P=0.047] predicted death. A significant (P<0.001) increasing trend in mortality was observed with increasing International Program on Chemical Safety Poisoning Severity Score (IPCS-CSS) grade.Interpretation & conclusions:C. collinus is a lethal poison associated with high mortality for which there is no specific antidote. Careful search and meticulous monitoring of the predictors of death and initiating appropriate corrective measures can be life saving.

show abstract

Section: Discussioncontrasting

confidence: 63%

Section: Discussioncontrasting

confidence: 52%

Section: Discussioncontrasting

confidence: 44%

“…There are only a few published human studies148910 available on C. collinus poisoning. However, in these studies severity of illness scoring systems was not used.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cleistanthus collinus poisoning

Naik

Harikrishna

Kumar

et al. 2016

Indian Journal of Medical Research

View full text Add to dashboard Cite

show abstract

“…The ingredients that make up the “Vishakallu” stone, which is used as an antidote for snakebite, are different herbs and pebbles available from the river banks. Likewise, aqueous paste and decoction obtained from the leaves of A. paniculata are widely used for snakebite treatment by indigenous people [43]. Previous studies have reported that ethnomedicine plays major roles in conserving the disappearing knowledge of tribal communities [44–47].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections

Samy

Manikandan

Qahtani

2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Traditional medicine plays a vital role for primary health care in India, where it is widely practiced to treat various ailments. Among those obtained from the healers, 78 medicinal plants were scientifically evaluated for antibacterial activity. Methanol extract of plants (100 μg of residue) was tested against the multidrug resistant (MDR) Gram-negative and Gram-positive bacteria. Forty-seven plants showed strong activity against Burkholderia pseudomallei (strain TES and KHW) and Staphylococcus aureus, of which Tragia involucrata L., Citrus acida Roxb. Hook.f., and Aegle marmelos (L.) Correa ex Roxb. showed powerful inhibition of bacteria. Eighteen plants displayed only a moderate effect, while six plants failed to provide any evidence of inhibition against the tested bacteria. Purified compounds showed higher antimicrobial activity than crude extracts. The compounds showed less toxic effect to the human skin fibroblasts (HEPK) cells than their corresponding aromatic fractions. Phytochemical screening indicates that the presence of various secondary metabolites may be responsible for this activity. Most of the plant extracts contained high levels of phenolic or polyphenolic compounds and exhibited activity against MDR pathogens. In conclusion, plants are promising agents that deserve further exploration. Lead molecules available from such extracts may serve as potential antimicrobial agents for future drug development to combat diseases caused by the MDR bacterial strains as reported in this study.

show abstract

Renal Disease in the Tropics

Schmeißer¹,

John²

2024

Manson's Tropical Diseases

View full text Add to dashboard Cite

A clinical study of renal tubular dysfunction inCleistanthus collinus(Oduvanthalai) poisoning

Cited by 23 publications

References 9 publications

Cleistanthus collinus poisoning

Cleistanthus collinus poisoning

Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections

Renal Disease in the Tropics

Contact Info

Product

Resources

About