A clinical study of syndromes of idiopathic (genetic) generalized epilepsy

Asadi‐Pooya, Ali A.; Emami, Mehrdad; Sperling, Michael R.

doi:10.1016/j.jns.2012.10.014

Cited by 43 publications

(29 citation statements)

References 14 publications

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“…2 Juvenile myoclonic epilepsy is often characterized by excellent response to treatment, 3 but delay to a correct diagnosis and consequently, choosing an inappropriate or suboptimal agent may result in uncontrolled seizures in many patients. 6 Besides, even a correct diagnosis does not guarantee an optimal response to therapy and many patients suffer from ongoing Table 1 Comparison of demographic and clinical characteristics of patients with JME, with or without seizures in their follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Juvenile myoclonic epilepsy is one of the most common epilepsy syndromes. Frequency of JME is about 9% of all epilepsies.…”

Section: Introductionmentioning

confidence: 99%

“…Frequency of JME is about 9% of all epilepsies. 2 Juvenile myoclonic epilepsy is often characterized by excellent response to treatment, if diagnosed correctly. 3 However, drug selection and treatment plan should be individualized, considering various factors including drug efficacy, patient's gender, age, and comorbidities, among other factors.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of seizure control in patients with juvenile myoclonic epilepsy (JME)

Asadi‐Pooya

Hashemzehi

Emami

2014

Seizure

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A correct diagnosis of JME does not guarantee an optimal response to therapy. Poorer drug adherence might result in more seizures; this should be highlighted for patients in every single visit. Longer follow-up gives the treating physician more time to adjust the drug(s) and formulate a plan that is appropriate for patients with difficult to treat seizures. We recommend valproate if seizure control is the main objective.

show abstract

Section: Discussionmentioning

confidence: 99%

“…1,2 Juvenile myoclonic epilepsy is one of the most common epilepsy syndromes. Frequency of JME is about 9% of all epilepsies.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Predictors of seizure control in patients with juvenile myoclonic epilepsy (JME)

Asadi‐Pooya

Hashemzehi

Emami

2014

Seizure

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Idiopathic (genetic) generalized epilepsies (IGEs) are common epilepsy syndromes with generalized seizures (ie, generalized tonic‐clonic, absence, and/or myoclonic seizures), that are diagnosed by strict clinical and electroencephalographic (EEG) criteria . Idiopathic generalized tonic‐clonic seizure (GTCS) is the most common seizure type among patients with IGE syndromes . Generalized tonic‐clonic seizures are also the most important of all seizure types in patients with epilepsy; GTCSs are associated with the highest risk of seizure‐related injuries and also with a significant risk for premature deaths in patients with epilepsy …”

Section: Introductionmentioning

confidence: 99%

Tonic‐clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome

Asadi‐Pooya

Homayoun

2020

Acta Neurol Scand

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Purpose We investigated the prevalence of generalized tonic‐clonic seizures (GTCSs) in patients with idiopathic generalized epilepsy (IGE) and the risk factors associated with them. We also studied the seizure outcome in patients with IGEs. Methods In this retrospective study, all patients with a diagnosis of IGE were recruited at the epilepsy clinic at Shiraz University of Medical Sciences, from 2008 through 2019. Age, gender, age at seizure onset, seizure type(s), EEG findings, and seizure outcome of all patients were registered. Results A total of 601 patients with IGE were studied; 516 patients (86%) had GTCSs. The ROC curve showed that reporting GTCSs was significantly associated with the time since the start of the disease (P = .0001; area under the curve = 0.71 [95% CI: 0.66‐0.76]; a cutoff point of 4 years [sensitivity = 61% and specificity = 76%]). Age at onset was 3.3 years later in patients with GTCSs compared with that in patients without GTCSs. Generalized spike‐wave complexes during interictal EEG recording were more frequently observed among patients without GTCSs. Generalized tonic‐clonic seizures were significantly associated with experiencing seizure‐related injuries. Valproate reduced the risk of experiencing GTCSs significantly (OR: 0.58; 95% CI: 0.34‐0.99; P = .04). Conclusion Generalized tonic‐clonic seizures do not affect the seizure outcome in patients with IGEs per se, but how we manage them significantly affects the seizure outcome in these patients. Failure to prescribe valproate for women with IGE, particularly when another first‐line treatment has failed, may not be in a patient's best interests.

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Efficacy and tolerability of brivaracetam monotherapy in childhood and juvenile absence epilepsy: An innovative adaptive trial design

et al. 2022

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Objective: Despite introduction of several antiseizure medications over the past two decades, treatment options for childhood absence epilepsy (CAE) and juvenile absence epilepsy (JAE) remain limited. We report the innovative adaptive design of an ongoing phase 2/3 trial to evaluate efficacy, safety, and tolerability of brivaracetam (BRV) monotherapy in patients 2-25 years of age with CAE or JAE. Methods: N01269 (Clini calTr ials.gov: NCT04666610; start: July 2021; expected completion: 2024) is a randomized, dose-finding and confirmatory, double-blind, placebo-controlled, parallel-group, multicenter trial. The trial consists of a dose-This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A clinical study of syndromes of idiopathic (genetic) generalized epilepsy

Cited by 43 publications

References 14 publications

Predictors of seizure control in patients with juvenile myoclonic epilepsy (JME)

Predictors of seizure control in patients with juvenile myoclonic epilepsy (JME)

Tonic‐clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome

Efficacy and tolerability of brivaracetam monotherapy in childhood and juvenile absence epilepsy: An innovative adaptive trial design

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