Predictors of seizure control in patients with juvenile myoclonic epilepsy (JME)

Abstract

A correct diagnosis of JME does not guarantee an optimal response to therapy. Poorer drug adherence might result in more seizures; this should be highlighted for patients in every single visit. Longer follow-up gives the treating physician more time to adjust the drug(s) and formulate a plan that is appropriate for patients with difficult to treat seizures. We recommend valproate if seizure control is the main objective.

Prolonged epileptic discharges predict seizure recurrence in JME: Insights from prolonged ambulatory EEG

“…5 However, even for GGE, such a strict correlation has not been formally established thus far 6 and, surprisingly, some authors even suggested that EEG abnormalities may not be valid predictors for seizure recurrence in these syndromes. 7 Among GGE, Juvenile Myoclonic Epilepsy (JME) is quite common; 8 it is characterized by the occurrence of major (generalized tonic clonic-GTC) and minor (myoclonic) motor seizures, with clinical onset in adolescence and young adulthood, and by a significant impact on key aspects of life such as driving, starting a working career and pregnancy. 9 Among GGE, JME is considered to have a peculiar physiopathology.…”

“…Data obtained in previous studies, 7,11,18 aimed at identifying such potential EEG predictors, were hindered by (1) the intra-/inter-study inhomogeneity of EEG recording lengths, timing, and activation method protocols, (2) the lack of quantitative methods of EEG recordings evaluation and, most importantly, by (3) the fact that EEG recordings are often followed by ASM regimen modification, which can alter the clinical outcome.…”

“…More in detail, while EDs in focal epilepsies are not considered as potential indicators of drug efficacy, 4 the occurrence of EDs in genetic generalized epilepsies (GGE) usually leads epileptologists to modify antiepileptic therapy 5 . However, even for GGE, such a strict correlation has not been formally established thus far 6 and, surprisingly, some authors even suggested that EEG abnormalities may not be valid predictors for seizure recurrence in these syndromes 7 …”

Evolution of genetically determined generalized epilepsies

“…у пациентов с ЮМЭ в исследовании A. Asadi-Pooya. Помимо этого, достаточно сильную связь с ремиссией показало наличие вальпроата в режиме терапии [41].…”

Problems of juvenile myoclonic epilepsy. A view through the prism of time

“…Обоснованный диагноз ЮМЭ, однако, еще не гарантирует оптимального ответа на терапию. Этот факт нашел свое отражение в работе [18] по иссле-дованию 116 пациентов с ЮМЭ, наблюдаемых по меньшей мере 18 мес каждый. У 68 пациентов за последние 12 мес приступов не было, а у 48 был зарегистрирован хотя бы один приступ разного типа.…”