A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation

Littara, A; Palmieri, Beniamino; Rottigni, Valentina; Iannitti, Tommaso

doi:10.1038/ijir.2013.13

Cited by 33 publications

(37 citation statements)

References 8 publications

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“…Hyaluronic acid injection is an interesting subcategory of potential PE treatments. The injections are placed in the dermis, increasing the distance between nerve endings and the skin . It serves the dual purpose of decreasing sensation while increasing the volume and girth of the penile head, theoretically increasing the sexual satisfaction of the patient's partner .…”

Section: Future Developmentsmentioning

confidence: 99%

“…The injections are placed in the dermis, increasing the distance between nerve endings and the skin . It serves the dual purpose of decreasing sensation while increasing the volume and girth of the penile head, theoretically increasing the sexual satisfaction of the patient's partner . After treatment, patients had an increased IELT as well as increased satisfaction from both partners .…”

Section: Future Developmentsmentioning

confidence: 99%

“…After treatment, patients had an increased IELT as well as increased satisfaction from both partners . However, the constancy of the changes in the volume of the penis has not been fully determined . At 5‐year follow up, the injection had decreased by an average of 15% .…”

Section: Future Developmentsmentioning

confidence: 99%

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Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going

et al. 2016

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Premature ejaculation is the most common form of sexual dysfunction among men. The pathophysiology of premature ejaculation appears to be multifactorial, implicating the need for multimodal therapeutic regimens to successfully treat premature ejaculation. Multiple treatment regimens have been shown to be effective in extending the time between penetration and ejaculation. These treatment modalities include everything from behavioral modifications and medications to diet alterations and major surgery. The goal of the present article was to review the commonly used treatment regimens used in the treatment of premature ejaculation, as well as to introduce and discuss the newest treatment routines under study for the treatment of premature ejaculation.

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Section: Future Developmentsmentioning

confidence: 99%

Section: Future Developmentsmentioning

confidence: 99%

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Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going

et al. 2016

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“…Addressing the above mentioned complications is crucial due to the increase in the clinical use of hyaluronic acid, not only in the aesthetic medicine clinic,17,18,19 but also in restorative medicine20 and for the treatment of other pathologies, such as lower-leg telangiectasia,21 premature ejaculation,22 and osteoarthritis 23,24,25…”

Section: Aimmentioning

confidence: 99%

Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

Iannitti¹,

Rottigni²,

Palmieri³

2013

DDDT

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Background and aimThe use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil®) to manage facial swelling, edema, inflammation, ecchymosis, and hematoma, when applied immediately after a facial rejuvenation procedure.Materials and methodsWe applied the plaster to the skin of 20 healthy patients for 12 hours immediately after hyaluronic acid-based procedure performed with the aim of erasing facial wrinkles of perioral and nasolabial folds and improving chin and eye contour. A further 20 patients underwent the same cosmetic procedure, but they were treated with an aescin 10% cream (applied immediately after the procedure, in the evening, and the morning after) and served as control group.ResultsBetesil® application resulted in a significant improvement in swelling/edema/inflammation score, if compared with aescin 10% cream (P < 0.01). As for facial ecchymosis and hematoma around the needle injection track, only two patients in the active treatment group displayed minimal ecchymosis and hematoma. In the control group, two patients presented minimal ecchymosis and three slight hematoma. However, using the ecchymosis/hematoma score, no significant difference between Betesil® and aescin 10% cream groups was observed. Patients’ satisfaction was significantly higher among subjects receiving Betesil®, if compared to patients receiving aescin 10% cream (P < 0.01).ConclusionThe present study supports the use of Betesil® plaster immediately after facial cosmetic procedures in order to safely control swelling, edema, and inflammation.

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“…Complications are very rare and easily manageable by expert surgeons (Littara et al, 2013). Filler materials have shown an important role in the field of glans penis augmentation and was found to prevent PE (Kwak et al, 2008;Abdallah et al, 2012).…”

Section: Hyaluronic Acidmentioning

confidence: 99%

The characterization, current medications, and promising therapeutics targets for premature ejaculation

Gür

Sikka

2015

Andrology

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SUMMARYPremature ejaculation (PE) is the most prevalent male sexual dysfunction. This is associated with negative personal and interpersonal psychological outcomes. The pharmacologic treatment of PE includes the use of antidepressants, local anesthetic agents, and phosphodiesterase type 5 inhibitors. While numerous treatments can control PE, only antidepressants and topical anesthetic creams and sprays have recently been shown to be more effective. This review focuses on the physiology and pharmacology of ejaculation, the pathophysiology of PE and the most effective pharmacological treatment of PE. Pharmacotherapy of PE with off-label shortacting selective serotonin reuptake inhibitors (SSRIs) is common, effective, and safe. Dapoxetine, a SSRI with a short half-life, has been recently evaluated for the treatment of PE by several countries and results are promising. In clinical practice, follow-up side effects are an important part of the management strategy for PE. The understanding of etiology, pathophysiology, and treatment modalities of PE would be beneficial to clinician in helping patients with this disappointing sexual problem.

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A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation

Cited by 33 publications

References 8 publications

Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going

Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going

Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

The characterization, current medications, and promising therapeutics targets for premature ejaculation

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