A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols for immobilization of healthy chimpanzees (Pan troglodytes)

Abstract

A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/-medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees

Cardiorespiratory effects of isoflurane and medetomidine–tiletamine–zolazepam in 12 bonobos (Pan paniscus)

“…However, it is important to note that most of these individuals had demonstrated cardiac pathology. In contrast, while the use of medetomidine was associated with a reduction in MAP and HR in chimpanzees, it was not associated with a significant decrease in cardiac function and output 19,20 …”

“…Successful orotracheal intubation was facilitated by a brief period of isoflurane delivered in oxygen via a face mask. Other great ape anaesthetic protocols have used a volatile agent alone, 8 nitrous oxide and a volatile agent 18 or ketamine or tiletamine/zolazepam increments 19 to improve the plane of anaesthesia for intubation. No sudden arousals occurred during the procedures, but the addition of the volatile agent for maintenance facilitated unforeseen surgery and diagnostics during the health checks and ensured staff safety at all times.…”

“…In contrast, while the use of medetomidine was associated with a reduction in MAP and HR in chimpanzees, it was not associated with a significant decrease in cardiac function and output. 19,20 In the current study, echocardiography commenced 34-68 minutes after medetomidine-tiletaminezolazepam administration during isoflurane maintenance with MAC hours between 0.11 and 0.28. In rats, dogs and cats the plasma/serum half-life of medetomidine was found to be between 58 and 96 minutes.…”

“…Bonobos (Pan paniscus) and chimpanzees (Pan troglodytes) are humans' closest living relatives, sharing over 97% of our DNA. 1 While the latter is a familiar species to many, with a presence in 96 European zoos, bonobos are less well recognised and are only found in 11 zoological collections in Europe (ZIMS Species Holdings, 19 August 2022; Species360 Zoological Information Management System; http://zims.species360.org/), one of which is in the UK at Twycross Zoo, Warwickshire. Zoological collections not only provide a vital genetic reservoir for the conservation of species, in addition to educating the public about the challenges faced by their wild counterparts, but they also provide the opportunity to study health and disease management.…”

Evaluation of Anesthetic and Cardiorespiratory Effects after Intramuscular Administration of Three Different Doses of Telazol® in Common Marmosets (Callithrix jacchus)

“…Their combination provides significant muscle relaxation [ 2 ]. The safe use of Telazol ® has already been documented in nonhuman primates including capuchin monkeys [ 11 , 12 ], owl monkeys [ 13 ], rhesus macaques [ 14 , 15 , 16 ], cynomolgus macaques [ 17 ], baboons [ 14 ], chimpanzees [ 18 , 19 , 20 ], and southern brown howler monkeys [ 21 ]. There are a few reports of Telazol ® administration to marmosets, showing a wide dose range [ 9 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”