A Clinical Trial of the Effects of a Dietary Pattern on Health Metrics and Fecal Metabolites in Volunteers With Risk of Cardiovascular Disease

Han, Kunchen; Ma, Jinke; Dou, Junxia; Hao, Dan; Zhu, Wenjun; Yu, Xiaobin; Zheng, Wenxuan; Song, Yao; Shi, Fengcui; Li, Quanyang

doi:10.3389/fnut.2022.853365

Cited by 12 publications

(7 citation statements)

References 64 publications

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“…Lower concentrations of proline, isoleucine, lysine, uracil, and xanthine after the P-diet were observed compared to the C-diet. Similarly reduced lysine levels were found after intervention with the Guangxi Longevity Dietary Pattern . In the multi-omics network, changes in lysine showed an inverse association with changes in Bifidobacterium, a direct association with changes in IL-6.…”

Section: Discussionmentioning

confidence: 99%

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Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Meng

Zhou²,

Zhang

et al. 2023

J. Agric. Food Chem.

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A high-compliance dietary intervention was conducted for 2 weeks in adults aged 50 years and older to investigate the preventing aging effects of a polyphenol-probiotic-enhanced diet (P-diet) by using inflammatory biological age (IBA). Following the P-diet, levels of interleukin-6 (IL-6), IL-10, and C-reactive protein were reduced. These effects were accompanied by a significant increase in the richness of Lactobacillus and Bifidobacterium and decrease in CAG_56, as well as an increase in butyrate and acetate and decrease in lysine, uracil, and valine. We optimized a model by a back propagation artificial neural network to evaluate the degree of aging, with an R 2 of 0.68. After the P-diet intervention, IBA was younger than chronological age and the inflammatory aging potential (Δage) was observably reduced by 90.12%, with change in Δage having a direct negative association with Akkermansia. Overall, P-diet may alleviate chronic low-grade inflammation and thus prevent the procession of inflammatory aging.

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Section: Discussionmentioning

confidence: 99%

“…Similarly reduced lysine levels were found after intervention with the Guangxi Longevity Dietary Pattern. 53 In the multiomics network, changes in lysine showed an inverse association with changes in Bifidobacterium, a direct association with changes in IL-6. Akkermansia was significantly negatively correlated with valine and leucine.…”

Section: ■ Discussionmentioning

confidence: 99%

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Meng

Zhou²,

Zhang

et al. 2023

J. Agric. Food Chem.

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“…DFC was prepared according to previously published recipes [ 2 , 3 ]. The primary DFC mixture contained sweet potato leaf, wolfberry leaf, bitter oatmeal, cabbage, banana, plantain, mandarin orange, and taro at a weight ratio of 1.4:1.3:0.98∶0.8:11.5:5.4:1.3:7.4.…”

Section: Methodsmentioning

confidence: 99%

“…), and fruits (Kumquat, plantain, etc.) and the intake of dietary fiber is relatively high [ 2 , 3 ], and dietary fiber is closely linked to the formation of longevity phenomenon, and longevity is closely related to the structure of the intestinal microenvironment or intestinal flora [ 4 ]. A specific bacterial community pattern and signature taxa of long-lived people were found in long-lived families, such as the enrichment of Enterobacteriaceae in all age groups and the higher abundances of Christensenellaceae , Verrucomicrobiaceae , Porphyromonadaceae , Rikenellaceae , Mogibacteriaceae , and Odoribacteraceae in long-lived elderly [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the effects of the dietary fiber compound mediated by a longevity dietary pattern on antioxidation, characteristic bacterial genera, and metabolites based on fecal metabolomics

Shi,

Liu,

Yue

et al. 2024

Nutr Metab (Lond)

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Background Age-related dysbiosis of the microbiota has been linked to various negative health outcomes. This study aims to investigate the effects of a newly discovered dietary fiber compound (DFC) on aging, intestinal microbiota, and related metabolic processes. The DFC was identified through in vitro fermentation screening experiments, and its dosage and composition were determined based on a longevity dietary pattern. Methods Aged SPF C57BL/6 J mice (65 weeks old) and young mice (8 weeks old) were divided into three groups: a subgroup without dietary fiber (NDF), a low DFC dose subgroup (LDF, 10% DFC), and a high DFC dose subgroup (HDF, 20% DFC). The total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD) activity, malondialdehyde (MDA) content, and glutathione peroxidase (GSH-Px) activity in liver and serum samples of the mice were measured according to the manufacturer’s protocol. The expression levels of characteristic bacterial genera and fecal metabolite concentrations in mice were determined using quantitative real-time PCR (qPCR) and nuclear magnetic resonance hydrogen spectroscopy (1H NMR). Metabolomics analysis was further conducted to identify biological functions and potential pathways related to aging. Results After an 8-weeks dietary intervention, DFC supplementation significantly attenuated age-related weight loss, organ degeneration, and oxidative stress. And promoted the growth of Lactobacillus and Bifidobacterium and inhibited the growth of Escherichia coli (E. coli) and Bacteroides (p < 0.05) in the intestinal tracts of aged mice. Metabolomic analysis identified glycolipid and amino acid metabolic pathway biomarkers associated with aging that were differentially regulated by DFC consumption. Correlation analysis between the identified microbial flora and the biomarkers revealed potential mechanistic links between altered microbial composition and metabolic activity with aging markers. Conclusions In conclusion, this study revealed an important mechanism by which DFC consumption impacts healthspan and longevity, shedding light on optimizing dietary fiber or developing fiber-based interventions to improve human health.

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“…Short chain acylcarnitines, byproducts of BCAA mitochondrial oxidation, were also found associated to AP, and their accumulation could reflect alterations in the FA oxidation process, which could promote the development of metabolic diseases [22 ▪▪ ]. Inversely, a protective effect of glycine on cardiovascular risk was reported [27,28]. Further, as PP are poor in lysine, that competes with arginine for transport into cells, plant food could thus increase arginine bioavailability, potentially improve the vascular function and then benefit cardiometabolic health [29].…”

Section: Amino Acid and Their Metabolitesmentioning

confidence: 99%

Metabolomics signatures of plant protein intake: effects of amino acids and compounds associated with plant protein on cardiometabolic health

Gueugneau

Capel

Monfoulet

et al. 2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewAn increase in the plant-based characteristics of the diet is now recommended for human and planetary health. There is growing evidence that plant protein (PP) intake has beneficial effects on cardiometabolic risk. However, proteins are not consumed isolated and the protein package (lipid species, fiber, vitamins, phytochemicals, etc) may contribute, besides the protein effects per se, to explain the beneficial effects associated with PP-rich diets. Recent findingsRecent studies have shown the potential of nutrimetabolomics to apprehend the complexity of both the human metabolism and the dietary habits, by providing signatures associated to the consumption of PP-rich diets. Those signatures comprised an important proportion of metabolites that were representative of the protein package, including specific amino acids (branched-chain amino acids and their derivates, glycine, lysine), but also lipid species (lysophosphatidylcholine, phosphatidylcholine, plasmalogens) and polyphenol metabolites (catechin sulfate, conjugated valerolactones and phenolic acids).

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A Clinical Trial of the Effects of a Dietary Pattern on Health Metrics and Fecal Metabolites in Volunteers With Risk of Cardiovascular Disease

Abstract: Graphical AbstractSchematic diagram of the study design (2 weeks dietary intervention, single arm intervention).

Cited by 12 publications

References 64 publications

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Using Inflammatory Biological Age To Evaluate the Preventing Aging Effect of a Polyphenol-Probiotic-Enhanced Dietary Pattern in Adults Aged 50 Years and Older

Exploring the effects of the dietary fiber compound mediated by a longevity dietary pattern on antioxidation, characteristic bacterial genera, and metabolites based on fecal metabolomics

Metabolomics signatures of plant protein intake: effects of amino acids and compounds associated with plant protein on cardiometabolic health

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