A Clinico-Histopathological Study of Orbital and Ocular Lesions; a Multicenter Study

Abstract

The study aimed at finding out the morphological and clinico-pathological correlation of Orbital and Ophthalmic lesions in various eye institutes of Nepal. The study also aimed at finding out the prevalence of Ophthalmic lesions needing histo­pathological examination. This cross sectional descriptive study was carried out in various tertiary eye hospitals of Nepal from 2008 – 2012. The department of pathology was also incorporated in giving the correct histopathological findings in time. All the relevant data were entered in a specifically designed proforma for the study and analyzed. One hundred Oph­thalmic and Orbital lesions were studied in various age groups. Ophthalmic and Orbital lesions were highest (18%) in 31-40 year age group patients. Eyelid (57%) was the most commonly involved site. Clinical diagnosis was consistent with histo­pathological diagnosis in more than 60% of the cases. Among eyelid lesions, incidence of dermoid cyst (21%) was highest. While in Conjunctival lesions, granuloma pyogenicum (22.5%) was highest followed by other lesions. A clinico-patho­logical diagnosis of malignant orbital tumors or ocular tumors was made in 30% of cases. While 70% cases of Ophthalmic or orbital lesions were benign in nature. All Ophthalmic lesions removed surgically should always (without exception) be subjected to histopathological examination to establish correct diagnosis for further management. However this study has shown that a good clinical examination and diagnosis before subjecting the patient for histopathological examination gives the patient and the treating surgeon a better outcome. DOI: http://dx.doi.org/10.3126/jcmc.v3i2.8442 Journal of Chitwan Medical College Vol.3(2) 2013 40-44

Spectrum of ocular lesions in a tertiary care centre: a five year retrospective study

“…[7][8][9][10] Both benign and malignant lesions of the eyelid and orbital tumors were most commonly seen in patients in the age group 30-40 years. It is in concordance with a study conducted by P Bastola et al 11 In our study, benign lesions were 58.73% while malignant lesions were 41.27%, while study conducted by Ud Din N et al 12 was quite similar to the present study, in which the benign and malignant lesions were found to be 61.5% and 38.5% respectively.…”

“…In a similar study conducted by Bastola et al Non-Hodgkin's lymphoma was commonest followed by rhabdomyosarcoma. 11 Most common malignant tumour of the lacrimal gland in the present study was found to be adenoid cystic carcinoma (ACC) which is in concordance with the literature as ACC comprises of about 25-30% of epithelial tumours of the lacrimal gland. 15 Like Ud-Din N et al study, most common malignancy in children in present study was also retinoblastoma.…”

“…13 In the study of Bastola, et al most common benign lesion was granuloma pyogenicum and most common malignant lesion was squamous cell carcinoma; similar with our findings. 11 Among eyelid malignancy, present study found the most common malignant lesion to be basal cell carcinoma which is in concordance with a study carried out by Jahagirdar SS et al 14 Amongst various orbital lesions Non-Hodgkin's lymphoma and rhabdomyosarcoma were commonest malignant lesions. In a similar study conducted by Bastola et al Non-Hodgkin's lymphoma was commonest followed by rhabdomyosarcoma.…”

Distribution and Histopathological Evaluation of Eyelid, Conjunctival and Orbital Tumours

“…Bastola et al found that most common benign lesions were granuloma pyogenicum(22.5%) followed by intradermal nevus (4.5%). In our study most common malignant lesion seen was squamous intraepithelial neoplasia consistent with other studies 12,13,14 . For the Orbital Tumours we studied we identified benign Tumours in 7 cases and malignant Tumour in 1 case.…”

“…Zaidi N et al found that benign Tumours were more frequent which were seen in 74.50% of all cases studied and malignant Tumours were seen in 25.50% 14 . Another study conducted by Bastola et al also found that benign lesions were more common which were seen in 79% of all cases studied and malignant lesions were seen in 21% 13 . In our study Benign lesions were represented by Nevus (4 cases), followed by dermolipoma (2 cases), papilloma (1 case) and dermoid cyst (1 case).…”