A Clinicopathologic Study of Primary Adenosquamous Carcinoma of the Liver

Kobayashi, Mariko; Okabayashi, Takehiro; Namikawa, Tsutomu; Araki, Keijiro

doi:10.1097/01.mcg.0000165705.74079.fc

Cited by 23 publications

(25 citation statements)

References 22 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adenosquamous cholangiocarcinoma (ASC) is a rare variant of cholangiocarcinoma, which was first described by Barr and Hancock in 1975 [11] and consists of malignant glandular and squamous components. Tumor cells have both mucin-producing glandular structures as in adenocarcinoma and irregularly shaped solid nests of polygonal cells with distinct cellular borders, eosinophilic cytoplasm, varying degrees of keratinization, and intercellular bridges as in squamous cell cancer [12][13] . Cholangiocarcinoma with squamous features have been previously described as ASC but also as mucoepidermoid carcinoma (mucus-producing cells and squamoid cells without keratin formation) and adenoacanthoma (squamous metaplasia) [6,14] .…”

Section: Discussionmentioning

confidence: 99%

“…Cholangiocarcinoma with squamous features have been previously described as ASC but also as mucoepidermoid carcinoma (mucus-producing cells and squamoid cells without keratin formation) and adenoacanthoma (squamous metaplasia) [6,14] . The prognosis of ASC is extremely poor even with surgery and most patients are not candidates for surgery and chemotherapy at presentation [2,6,12] . Nakajima and Kondo [2] evaluated 11 patients with ASC and compared their prognosis with 82 cholangiocarcinoma patients with adenocarcinoma features and found that the mean overall survival was four months in ASC patients versus 6.9 months in the latter.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cholangiocarcinoma Presenting as Humoral Hypercalcemia of Malignancy: A Case Report and Literature Review

Erdinc¹,

Ramachandran²,

Yadav³

et al. 2019

Cureus

View full text Add to dashboard Cite

Humoral hypercalcemia of malignancy (HHM) is most commonly encountered in squamous cell carcinoma (SCC) of different organs, and It is characterized by elevated parathyroid hormonerelated peptide (PTHrP) levels. It may be seen as a manifestation of cholangiocarcinoma (CCC) at presentation and later in the course of the disease. However, HHM due to intrahepatic cholangiocarcinoma is a rare association and is associated with a poor prognosis. We herein report a case of hypercalcemia presenting as the first manifestation of an underlying rare variant of intrahepatic cholangiocarcinoma. Our patient is a 57-year-old male who presented to the emergency room with severe symptoms of constipation and polyuria and was admitted to the hospital for symptomatic hypercalcemia. He was found to have a hypermetabolic 15 cm liver mass, abdominal lymph nodes on imaging, which was subsequently diagnosed as adenosquamous cholangiocarcinoma by liver biopsy. This necessitated an urgent inpatient treatment with gemcitabine/cisplatin combination chemotherapy to control the aggressive nature of the malignancy. However, he deteriorated and expired after three months of his diagnosis. Adenosquamous cholangiocarcinoma is a very rare variant of a liver tumor. It develops due to squamous metaplasia of an underlying cholangiocarcinoma and usually has aggressive clinicopathological features. HMM is a life-threatening, yet unrecognized, phenomenon of cholangiocarcinoma, which represents a poor prognostic marker. Prompt recognition of this complication is important for preventing serious complications associated with hypercalcemia and to improve the quality of life of these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cholangiocarcinoma Presenting as Humoral Hypercalcemia of Malignancy: A Case Report and Literature Review

Erdinc¹,

Ramachandran²,

Yadav³

et al. 2019

Cureus

View full text Add to dashboard Cite

show abstract

“…7 The mean survival of these 34 cases was 8.7 months. Multivariate analysis revealed that lymph node metastasis and the elevation of total bilirubin were associated with poor survival after surgery, and lymph node metastasis, intra-hepatic metastasis, location of tumor in the right lobe, and the pathologic stage were significant factors for all cases.…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological study of primary carcinoma of the liver

Dasharatham¹,

Kumar

2017

Int J Adv Med

View full text Add to dashboard Cite

Background: Since the incidence of the primary carcinoma of the liver in Warangal is very high when compared to other parts of the country, the possible etiological factors have been studied for the increasing frequency of Primary carcinoma of the liver with a view for further follow up. The objective of the present study was to undertake a thorough study of histopathological changes, typing and its association with cirrhosis.Methods: A hospital based cross sectional study was carried for a period of three years among 56 cases of primary carcinoma of the liver at MGM hospital. Institutional Ethics Committee permission was obtained. Informed consent was taken from each and every patient. Detailed history, clinical examination and investigations were carried out for each and every included patient. Liver biopsy was done under strict aseptic precautions.Results: The incidence of Primary carcinoma of the liver was found to be highest in males as compared to females. The highest incidence of Primary carcinoma of the liver was found in the age group of 41-50 years. In only 14.3% of cases the Primary carcinoma of the liver was associated with cirrhosis of liver. The most common type of cell found on histopathology was cylindroids type in 35.7% of cases followed by trabecular type in 28.5% of cases.Conclusions: Incidence of Primary carcinoma of the liver was found to be very high. This was not associated with corresponding increase in cirrhosis. The cause of their increase was obscure.

show abstract

“…ASC is a rare subtype of cholangiocarcinoma with more aggressive clinical and pathological features than other cholangiocarcinomas, and the prognosis of patients with hepatic ASC is extremely poor. Kobayashi et al [6] reported a mean survival time for patients with hepatic ASC of 8.7 months, and the overall 1-, 2-, and 3-year survival rates after surgery were 38.5, 16.2, and 10.8%, respectively. Uenishi et al [15] reported a 1-year survival rate for intrahepatic cholangiocarcinoma of 68%, indicating that the prognosis of patients with primary hepatic ASC was poorer than that of patients with the common type of hepatic cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…ASC contains both adenocarcinoma (AC) and squamous cell carcinoma (SCC) components, tends to present more aggressive clinicopathologic features, and has a poorer prognosis than other cholangiocarcinomas [6,7] . Barr and Hancock [8] first reported a case of primary hepatic ASC in 1975, since when several cases of histologically defined primary hepatic ASC have been reported in the literature [3, [9][10][11][12] ; however, none have been reported in patients with PSC.…”

mentioning

confidence: 99%

Primary Hepatic Adenosquamous Carcinoma Associated with Primary Sclerosing Cholangitis

Yamao¹,

Takenaka²,

Imai³

et al. 2017

Oncology

View full text Add to dashboard Cite

Introduction: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disorder characterized by multiple fibrotic strictures of the bile duct. More than 40% of deaths in PSC patients are related to malignant tumors, including cholangiocarcinoma. Primary hepatic adenosquamous carcinoma (ASC) is a rare subtype of cholangiocarcinoma containing adenocarcinoma (AC) and squamous cell carcinoma (SCC) components, with a poorer prognosis than other cholangiocarcinomas. We report the first case of a hepatic ASC in a patient with PSC. Case Report: A 28-year-old man was referred for diagnosis and treatment of a liver abscess suspected by contrast-enhanced computed tomography (CE-CT). He had a history of ulcerative colitis and PSC. Abdominal CE-CT revealed a 60-mm-diameter ring-shaped mass with central necrosis in the left lobe. Magnetic resonance imaging demonstrated a poorly circumscribed low-signal-intensity mass in T1-weighted imaging and a high-signal-intensity mass with a scattered low-signal-intensity area in T2-weighted imaging. Abdominal ultrasonography showed a hypoechoic component with a diffuse hyperechoic area in the tumor. Ultrasound-guided biopsy and histological examination showed tumor cells with both squamous and glandular differentiation. Left lobectomy was performed. Microscopic examination revealed 2 components, including moderately differentiated AC and well-differentiated SCC. The final diagnosis was hepatic ASC. Conclusion: This is the first reported case of hepatic ASC in a patient with PSC. Patients with PSC should be recognized as being at a risk of not only general cholangiocarcinoma, hepatocellular carcinoma, and metastatic liver tumor, but also ASC.

show abstract

A Clinicopathologic Study of Primary Adenosquamous Carcinoma of the Liver

Abstract: The current study highlights the prognostic factors of ASC of the liver, showing that the prognosis for patients with ASC is poor.

Cited by 23 publications

References 22 publications

Cholangiocarcinoma Presenting as Humoral Hypercalcemia of Malignancy: A Case Report and Literature Review

Cholangiocarcinoma Presenting as Humoral Hypercalcemia of Malignancy: A Case Report and Literature Review

Clinico-pathological study of primary carcinoma of the liver

Primary Hepatic Adenosquamous Carcinoma Associated with Primary Sclerosing Cholangitis

Contact Info

Product

Resources

About