A Clinicopathological Study of Minute Polypoid Lesions of the Colon based on Magnifying Fiber-Colonoscopy and Dissecting Microscopy

Abstract

Magnifying fiber-colonoscopy reveals that adenoma, minute carcinomatous lesion in an adenoma (which is termed focal carcinoma), and mucosal carcinoma of the colon, each has its own characteristic pit pattern. Inspection by dissecting microscope of resected specimens obtained from subjects whose colonic mucosa had been considered normal, often reveals an abnormal pit pattern of less than 1 mm, and subsequent histologic examination confirms the frequent presence of incipient adenoma. Clinical magnification inspection of areas of colonic mucosa considered normal on the basis of ordinary observation, reveals pit patterns identical to those seen in resected specimens.

Pit pattern and three-dimensional configuration of isolated crypts from the patients with colorectal neoplasm

“…Endoscopic observation of pit pattern began in the 1970s, 21,22 but its clinical application only commenced in the 1990s. 4 Endoscopists will be able to speculate on the histopathological diagnosis by applying objective information on pit patterns.…”

Pit Pattern in Colorectal Neoplasia: Endoscopic Magnifying View

“…The surface microstructure of colorectal epithelium was first analyzed using dissecting microscopes on resected specimens in the 1970 s. The surface morphology in normal rectal mucosa was described by Bank et al [1], and subsequent investigations have demonstrated structural alterations in colorectal epithelial neoplasms. In the early 1980 s Nishizawa et al [2] stressed that the normal colonic mucosa, adenoma, and adenocarcinoma showed their own characteristic surface structures. Kawano et al analyzed the stereomicroscopic pit pattern of depressed colorectal carcinoma [3].…”

Evaluation of the type V pit pattern in the lesions of colonic Tis and T1 cancer

“…Endoscopic observation of pit patterns began in the 1970s, 16,17 but its clinical application only started in the 1990s 4 . This pit pattern diagnosis progressed over the same period with the spread of the video endoscope.…”