A Clomiphene Citrate and Letrozol Varsus Tamoxifen and Letrozole as an Infertility Treatment in Women with Polycystic Ovary Syndrome

Athar, Rasekhjahromi; Maalhagh, Mehrnoosh; Hosseinpoor, Masoumeh; Hooshmand, Farhang; Alavi, Fatemeh

doi:10.3923/pjbs.2015.300.303

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…Also, Rasekhjahromi Atharn et al on 2015 found that combination of Clomid and Letrozole for induction of ovulation in PCOS patients has good ovulation rate 20% [21] . Also, Abu Hashim et al reported that 30% of their PCOS patients were resistant to clomiphene, but Letrozole induced an ovulation rate in those CC-resistant patients (64.9%) with pregnancy rate of 14.7% [11] .…”

Section: Discussionmentioning

confidence: 99%

“…But Masomeh et al (2013) reported that there was 23.8% abortion rate with combined CC and Letrozole therapy [15] . Also, Rasekhjahromi Athar et al (2015) reported miscarriage rate of about 2.4 % with CC plus Letrozole in PCOS infertile females [21] . Speroff and Fritz reported that the frequency of abortion following gonadotropins in their clomiphene-resistant patients was 20%-25%, which is more than that in the general population (15%).…”

Section: Discussionmentioning

confidence: 99%

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Combined Letrozole and Clomiphene versus Letrozole with low dose gonadotropin protocol for ovulation induction in infertile clomiphene-resistant women with polycystic ovary syndrome: Comparative study

Harira

2018

Evidence Based Women's Health Journal

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combined Letrozole and Clomiphene versus Letrozole with low dose gonadotropin protocol for ovulation induction in infertile clomiphene-resistant women with polycystic ovary syndrome: Comparative study

Harira

2018

Evidence Based Women's Health Journal

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“…We determined the dosage of the herbal regimen using the Physician's Desk Reference (PDR) [17]. Herbal pharmacologist at Jahrom University of Medical Sciences, Iran, has found herbarium Nigella sativa code number A4017009P and black pepper code number PM 1310-Peper nigrum L. The dosage administered to the control group was determined based on prior research [18]. Intervention group: From the third to the seventh day of the menstrual cycle for three months, take five capsules of NigellaSativa (each capsule contains 550 mg of pure powder) and five capsules of black pepper (each capsule contains 550 mg of pure powder).Control Group: 10 mg Tamoxifen (two tablets per day, SHAFA Company) and 2.5 mg Letrozole (two tablets per day, Alborz Company) from the 3 rd to 7 th day of the menstrual cycle.…”

Section: Interventionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Background: Polycystic ovary syndrome (PCOS), one of the most common reasons for infertility in terms of anovulation, influences 4-7% of reproductive women. Objectives: This study aimed to compare the impact of Nigella sativa + black pepper with Letrozole + Tamoxifen as a treatment for infertile women with PCOS. Methods: 90 PCOS infertile women aged 18 and 42 who were sent to an infertility clinic took part in this randomized, double-blind and clinical experiment. Patients were split into intervention and control groups at random. Letrozole and Tamoxifen were utilized in the control group. In contrast, Nigella sativa and black pepper were employed in the intervention group (from the third to the seventh day of the menstrual cycle). Throughout therapy, transvaginal ultrasound measures such as ovarian follicular size, number, and endometrial thickness were monitored, and the medication regimen was maintained according to these characteristics. Results: In the intervention and control groups, the pregnancy rate was 22 (48.8%) and 5(11.1%), respectively (p=0.021). On day 12 of the menstrual cycle, there was a significant difference between the two groups endometrial thickness, dominant follicle size, and the number of follicles (p<0.05). The incidence of Ovarian Hyperstimulation Syndrome (OHSS) did not significantly vary between the two groups (p>0.05). Conclusion: Increased pregnancy rates are finally brought on by the favorable effects of Nigella sativa and black pepper on the size of dominant follicle and endometrial thickness. Consequently, despite the necessity for standardization by the applied research laboratory of medicinal plants and further clinical trial research, we advise using this low-cost, low-side-effect regimen to treat infertile PCOS patients.

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Safety of clomiphene citrate: a literature review

et al. 2017

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Clomiphene citrate (CC) is a nonsteroidal compound and induces ovulation indirectly. The wide usage of the CC raises a question; is it safe or not? In the light of this question, this review aimed to highlight all researches and insights into the association between the use of CC and risk of genotoxicity, cytotoxicity, embryotoxicity, teratogenicity and risk of different cancer types. We conducted a MEDLINE/PubMed, Scopus, Web of Science, Google Scholar search. After a careful screening process of all authors, 32 of these articles were considered as appropriate, and reviewed. Our evaluations showed that CC has genotoxic, cytotoxic, embryotoxic and teratogenic properties. There is no association between the use of CC and risk of ovarian, breast, uterine, cervix, endometrium, lung, colorectal cancer, and lymphoma. However, risk increased especially after 6 cycles of use and especially in nulligravid women. The use of CC should be restricted to 6 cycles. Moreover, malignant melanoma and thyroid cancer risk was found to be higher among CC treated women in almost all studies. Further works should be conducted especially in animal models to assess its risk features.

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A Clomiphene Citrate and Letrozol Varsus Tamoxifen and Letrozole as an Infertility Treatment in Women with Polycystic Ovary Syndrome

Cited by 3 publications

References 25 publications

Combined Letrozole and Clomiphene versus Letrozole with low dose gonadotropin protocol for ovulation induction in infertile clomiphene-resistant women with polycystic ovary syndrome: Comparative study

Combined Letrozole and Clomiphene versus Letrozole with low dose gonadotropin protocol for ovulation induction in infertile clomiphene-resistant women with polycystic ovary syndrome: Comparative study

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Safety of clomiphene citrate: a literature review

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