Combined Letrozole and Clomiphene versus Letrozole with low dose gonadotropin protocol for ovulation induction in infertile clomiphene-resistant women with polycystic ovary syndrome: Comparative study

Abstract

Objectives: To compare the effect of combined clomiphene citrate (100mg) and Letrozole (5mg) versus Letrozole (5mg) followed by gonadotropin injection for one cycle in CC resistant PCOs patients. Design: Prospective randomized trial.

Letrozole versus Gonadotropins for Ovulation Induction in Clomiphene Citrate Resistance: A Randomized Controlled Study

“…This is in good agreement with reports of other studies which conclude that letrozole has a better ovulation and pregnancy rate as compared to CC in patients with PCOS. An ovulation rate of 54.6% and pregnancy rate of 25% with letrozole induction in CC-resistant women with PCOS was reported by Harira [14]. They observed the ovulation rate to be 79.3% and the pregnancy rate 23.39% with letrozole.…”