A Cluster of Bloodstream Infections Caused by<i>Streptococcus gallolyticus</i>Subspecies<i>pasteurianus</i>That Involved 5 Preterm Neonates in a University Hospital during a 2-Month Period

Floret, N.; Bailly, Pascale; Thouverez, Michelle; Blanchot, C.; Alez-Martin, Dolores; Menget, A.; Thiriez, Gérard; Hoen, B.; Talon, D.; Bertrand, Xavier

doi:10.1086/650380

Cited by 32 publications

(28 citation statements)

References 9 publications

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“…pasteurianus. Four of five isolates were genetically identical to each other, with the fifth isolate closely resembling the other four (7). The etiology of this outbreak was postulated to be environmental contamination followed by transient hand carriage by a staff member; therefore, these infections were likely the result of one index case, followed by a breakdown in infection control measures.…”

Section: Discussionmentioning

confidence: 90%

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A Longitudinal Case Series Description of Meningitis Due to Streptococcus gallolyticus subsp. pasteurianus in Infants

et al. 2012

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Streptococcus gallolyticus subsp. pasteurianus, previously known as Streptococcus bovis biotype II.2, is known to cause multiple infectious complications, including bacterial meningitis, in adults. Only sporadic individual case reports have identified this pathogen as a cause of meningitis in infants. This study is the first to longitudinally document S. gallolyticus subsp. pasteurianus as a cause of meningitis in four epidemiologically unrelated infants less than 2 weeks of age. The 16S rRNA gene sequences of all 4 isolates were identical, and further were identical to 3 central nervous system (CNS) strains (two adults and one child) reported in existing literature. S. gallolyticus subsp. pasteurianus is an increasingly recognized cause of meningitis and bacteremia in the newborn period, and it merits further study with respect to etiology of infection.

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Section: Discussionmentioning

confidence: 90%

“…pasteurianus in a 16-bed neonatal intensive care unit (NICU) in France. All five infections occurred within 11 days of one another, and the authors could not rule out health care worker transmission from one child to another (7).…”

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confidence: 92%

A Longitudinal Case Series Description of Meningitis Due to Streptococcus gallolyticus subsp. pasteurianus in Infants

et al. 2012

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“…S. gallolyticus subsp. pasteurianus has been reported to cause human neonatal meningitis and septicaemia (Gavin et al, 2003;Onoyama et al, 2009;Floret et al, 2010;Nagamatsu et al, 2012); however, to our knowledge, there have been no reports of it being isolated from healthy subjects. These facts and our results suggest that S. gallolyticus subsp.…”

Section: Discussionmentioning

confidence: 97%

Development of a multilocus sequence typing scheme for Streptococcus gallolyticus

et al. 2014

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Streptococcus gallolyticus is often found as a member of the normal gut microflora in various animals. However, it has been reported to cause mastitis in cattle, septicaemia in pigeons, and meningitis, septicaemia and endocarditis in humans. However, little is known about the epidemiology and crucial virulence factors of S. gallolyticus. To help address these issues, we developed a multilocus sequence typing (MLST) scheme for S. gallolyticus. Seven housekeeping gene fragments were sequenced from each of 58 S. gallolyticus isolates collected from diverse origins and sources. The MLST scheme had good discriminatory ability. The 63 strains, including the 5 whole genome sequenced strains examined, resolved into 57 sequence types (STs), with 52 STs represented by only a single strain. With respect to the identification of S. gallolyticus subspecies (i.e. S. gallolyticus subsp. gallolyticus, S. gallolyticus subsp. pasteurianus and S. gallolyticus subsp. macedonicus), the results of biochemical tests and DNA-DNA hybridization were in high concordance with those of the MLST scheme. The MLST scheme developed in this study may be a useful tool capable of replacing the conventional methods used for S. gallolyticus subspecies identification. The results of this study suggest that the biology and virulence of two pathogenic S. gallolyticus subspecies (i.e. S. gallolyticus subsp. gallolyticus and S. gallolyticus subsp. pasteurianus) are very different. The MLST scheme offers researchers a valuable typing tool that will promote further investigation of the epidemiology of S. gallolyticus.

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“…The number of publications where the causative agent was reported to be S. bovis type II/2 or S. pasteurianus was seven and the total number of cases was 14 (one publication included five cases, one publication included four cases and the other publications included single cases) (1,5,(7)(8)(9)(10)(11). When these cases were examined, it was noted that term and preterm babies were affected equally, early and late infection rates were similar, but early infection was observed in term babies and late infection was observed in preterm babies, no risk factor was present for early and late sepsis, meningitis accompanied 64% of the cases and meningitis was mostly observed in the patients in whom early infection was developed and was manifested with clinical findings similar to group B sterptococci and E. coli infections.…”

Section: Discussionmentioning

confidence: 99%

Late-onset Streptococcus pasteurianus sepsis in a preterm baby in a neonatal intensive care unit

et al. 2014

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A Cluster of Bloodstream Infections Caused byStreptococcus gallolyticusSubspeciespasteurianusThat Involved 5 Preterm Neonates in a University Hospital during a 2-Month Period

Cited by 32 publications

References 9 publications

A Longitudinal Case Series Description of Meningitis Due to Streptococcus gallolyticus subsp. pasteurianus in Infants

A Longitudinal Case Series Description of Meningitis Due to Streptococcus gallolyticus subsp. pasteurianus in Infants

Development of a multilocus sequence typing scheme for Streptococcus gallolyticus

Late-onset Streptococcus pasteurianus sepsis in a preterm baby in a neonatal intensive care unit

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