A Cocktail of Industrial Chemicals in Lipstick and Nail Polish: Profiles and Health Implications

Tang, Shuqin; Chen, Yu-Kun; Song, Guixian; Liu, Xiaotu; Shi, Yumeng; Xie, Qitong; Chen, Da

doi:10.1021/acs.estlett.1c00512

Cited by 18 publications

(12 citation statements)

References 26 publications

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“…They included GMO (median: 61 600 ng/g), MO (16 400 ng/g), butyl oleate (BO; 411 ng/g), 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (TMPDMiB; 341 ng/g), TMPDDiB (105 ng/g), isopropyl myristate (IPMS; 154 ng/g), n -propyl oleate (PO; 88.9 ng/g), di(2-ethylhexyl) sebacate (DEHS; 69.1 ng/g), triisononyl trimellitate (TiNTM; 64.4 ng/g), diisooctyl azelate/di(2-ethylhexyl) azelate (DIAZ/DEHAZ; 40.2 ng/g), diethyl succinate (DESU; 14.2 ng/g), and tetrahydrofurfuryl oleate (THFO; 3.2 ng/g). Although some of them have been reported in commercial beauty products and facemasks as a demonstration of industrial applications, , none of them had been detected in any environmental compartments prior to our work. GMO exhibited the highest concentrations among target plasticizers, accounting for 58.4% of the total concentrations.…”

Section: Resultsmentioning

confidence: 80%

Emerging Plasticizers in South China House Dust and Hand Wipes: Calling for Potential Concern?

Lin

Tan

Qiao

et al. 2022

Environ. Sci. Technol.

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Following regulations on legacy plasticizers, a large variety of industrial chemicals have been employed as substitutes to manufacture consumer products. However, knowledge remains limited on their environmental distributions, fate, and human exposure risks. In the present work, we screened for a total of 34 emerging plasticizers in house dust from South China and matched hand wipes collected from volunteers (n = 49 pairs). The results revealed a frequent detection of 27 emerging plasticizers in house dust, with the total concentrations reaching a median level of 106 700 ng/g. Thirteen of them had never been investigated by any environmental studies prior to our work, which included glycerol monooleate (median: 61 600 ng/g), methyl oleate (16 400 ng/g), butyl oleate (411 ng/g), 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (341 ng/g), 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (105 ng/g), isopropyl myristate (154 ng/g), di(2-ethylhexyl) sebacate (69.1 ng/g), triisononyl trimellitate (64.4 ng/g), as well as a few others. Emerging plasticizers were also frequently detected in hand wipes, with a median total level of 4680 ng, indicating potential exposure via hand-to-mouth contact. Several chemicals, including acetyl tributyl citrate, tributyl citrate, di-n-butyl maleate, isopropyl myristate, and isopropyl palmitate, exhibited significant correlations between dust and hand wipe. However, other plasticizers did not follow this pattern, and the chemical compositional profiles differed between dust and hand wipe, suggesting chemical-specific sources and exposure pathways. Although the estimation of daily intake (EDI) indicated no substantial risks through dust ingestion or hand-to-mouth transfer of emerging plasticizers, continuous monitoring is needed to explore whether some of the important plasticizers are safe replacements or regrettable substitutions of the legacy ones.

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Section: Resultsmentioning

confidence: 80%

Emerging Plasticizers in South China House Dust and Hand Wipes: Calling for Potential Concern?

Lin

Tan

Qiao

et al. 2022

Environ. Sci. Technol.

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“…Beyond a rather small group of plasticizers and antioxidants included in the present study, there exists a large suite of plastic additives currently in use. Our recent studies have revealed various types of plastic additives in ambient fine particulate matter, house dust, personal care products, and human hand wipes, including plasticizers, synthetic antioxidants, UV stabilizers, PAEs, OPEs, and bisphenols. ,, These findings indicate the very complexity of plastic additives humans are likely exposed to. However, very little effort has been undertaken to elucidate human exposure pathways, internal exposure levels, and potential adverse health outcomes of emerging plastic additives .…”

Section: Resultsmentioning

confidence: 99%

“…The recoveries of individual analytes (mean ± standard deviation) ranged from 59 (±7.1)% for N,N′ -hexane-1,6-diylbis(3-(3,5-di- tert -butyl-4-hydroxyphenyl)propionamide) (AO1098) to 134 (±20)% for 2,4-bis(octylthio)-6-(4-hydroxy-3,5-di- tert -butylanilino)-1,3,5-triazine (AO425), after subtracting the original residues in blanks. Matrix effects were evaluated with our previously reported method, and the results revealed acceptable matrix effects for most target chemicals (Table S1). The details on the matrix effect evaluation are summarized in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Emerging Plasticizers and Synthetic Antioxidants and Their Potency to Cross Human Placenta

Tang

Sun

Qiao

et al. 2022

Environ. Sci. Technol.

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Gestational exposure to environmental chemicals and subsequent permeation through the placental barrier represents potential health risks to both pregnant women and their fetuses. In the present study, we explored prenatal exposure to a suite of 46 emerging plasticizers and synthetic antioxidants (including five transformation products of 2,6-di-tert-butyl-4-hydroxytoluene, BHT) and their potency to cross human placenta based on a total of 109 maternal and cord serum pairs. Most of these chemicals have rarely or never been investigated for prenatal exposure and associated health risks. Eleven of them exhibited detection frequency greater than 50% in maternal blood, including dibutyl fumarate (DBF), 2,6-di-tert-butylphenol (2,4-DtBP), 1,3-diphenylguanidine (DPG), methyl-2-(benzoyl)benzoate (MBB), triethyl citrate (TEC), BHT, and its five metabolites, with a median concentration from 0.05 to 3.1 ng/mL. The transplacental transfer efficiency (TTE) was determined for selected chemicals with valid measurements in more than 10 maternal/cord blood pairs, and the mean TTEs exhibited a large variation (i.e., 0.29–2.14) between chemicals. The determined TTEs for some of the target chemicals were comparable to the predicted values by our previously proposed models developed from molecular descriptors, indicating that their transplacental transfer potency could be largely affected by physicochemical properties and molecular structures. However, additional biological and physiological factors may influence the potency of environmental chemicals to cross human placenta. Overall, our study findings raise concern on human exposure to an increasing list of plastic additives during critical life stages (e.g., pregnancy) and potential health risks.

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“…OPEs have also been detected in beauty products. The direct dermal sorption exposure to humans may cause health effects. , TDP is possibly one of the OPE additives added in beauty products and is released in the environment. Hence, Spearman correlation analysis was conducted for TDP and other target OPEs with DFs higher than 60% for determination of potential sources of TDP around the 12 lakes.…”

Section: Resultsmentioning

confidence: 99%

Recognition of Organophosphate Esters (OPEs) in the Sediment of 12 Lakes in the Taihu Lake Basin of China

Xing

et al. 2022

ACS EST Water

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Organophosphate esters (OPEs) have been frequently detected in various environmental matrices. However, there is a lack of investigation on comprehensively screening for potential OPEs from the known to the unknown, especially for the ones in surface sediments, which play an important role in the fate of OPEs in the environment. Thus, target, suspect, and nontarget screening of OPEs in n = 65 surface sediments from 12 lakes around Taihu Lake was investigated by a developed strategy of ultrahigh-performance liquid chromatography with Q Exactive hybrid quadrupole-Orbitrap highresolution mass spectrometry (UHPLC−Q-Orbitrap HRMS) in this study. For target screening, 17 OPEs were detected in 5−100% of the sediment samples with ∑ 20 OPEs (sum of the OPE concentrations) ranging from 34.8 to 623 ng/g dw (median of 106 ng/g dw). Surprisingly, tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP, median of 72.1 ng/g dw) was the dominant OPE congener with a DF of 100%. For suspect screening, 16 OPEs were successfully identified. Interestingly, (2,4-di-tert-butylphenyl)pentaerythritol phosphatenovel (mBDTPDP, median of 5.51 ng/g dw, DF of 100%) and bis(2,4-di-tert-butylphenyl)pentaerythritol diphosphate (BDTPDP, median of 3.46 ng/g dw, DF of 78.0%) were the two most frequently detected ones. Beyond that, three unknown peaks were detected for the nontarget screening method, while tridodecyl phosphate (TDP) showed high abundance in 12 lakes (median of 0.59 ng/g dw, DFs of 86%), which may be additives applied in cosmetics. These results indicate that some unreported OPE congeners are ubiquitous in sediment samples, which were unfortunately overlooked previously.

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A Cocktail of Industrial Chemicals in Lipstick and Nail Polish: Profiles and Health Implications

Cited by 18 publications

References 26 publications

Emerging Plasticizers in South China House Dust and Hand Wipes: Calling for Potential Concern?

Emerging Plasticizers in South China House Dust and Hand Wipes: Calling for Potential Concern?

Prenatal Exposure to Emerging Plasticizers and Synthetic Antioxidants and Their Potency to Cross Human Placenta

Recognition of Organophosphate Esters (OPEs) in the Sediment of 12 Lakes in the Taihu Lake Basin of China

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