A Cohort Study of Thyroid Cancer and Other Thyroid Diseases After the Chornobyl Accident: Thyroid Cancer in Ukraine Detected During First Screening

Тronko, М.D.; Howe, Geoffrey R.; Bogdanova, Tetiana; Bouville, André; Epstein, Ovsiy V.; Brill, A.B.; Likhtarev, I.A.; Fink, Daniel; Markov, Valentyn V.; Greenebaum, Ellen; Olijnyk, Valery A.; Masnyk, Ihor J.; Shpak, Victor; McConnell, Robert J.; Tereshchenko, Valery P.; Robbins, Jacob; Zvinchuk, Alexander; Zablotska, Lydia B.; Hatch, Maureen; Luckyanov, Nickolas; Ron, Elaine; Thomas, Terry L.; Voilleque, P.G.; Beebe, Gilbert W.

doi:10.1093/jnci/djj244

Cited by 219 publications

(205 citation statements)

References 22 publications

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“…One cohort study using individual thyroid dose estimates has also been reported. That study found a significant association between estimated thyroid dose and thyroid cancer risk in a Ukrainian cohort of about 13,500 persons who were less than 18 years old at the time of the accident (20).…”

Section: Introductionmentioning

confidence: 91%

ret/PTC Activation Is Not Associated with Individual Radiation Dose Estimates in a Pilot Study of Neoplastic Thyroid Nodules Arising in Russian Children and Adults Exposed to Chernobyl Fallout

Tuttle

Lukes

Onstad

et al. 2008

Thyroid

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Section: Introductionmentioning

confidence: 91%

ret/PTC Activation Is Not Associated with Individual Radiation Dose Estimates in a Pilot Study of Neoplastic Thyroid Nodules Arising in Russian Children and Adults Exposed to Chernobyl Fallout

Tuttle

Lukes

Onstad

et al. 2008

Thyroid

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“…This is also reviewed in a paper in this Special Edition by Thomas et During the first screening in 1998-2000, 45 thyroid cancers were detected in Ukraine [52].…”

Section: Major Medical and Epidemiological Studies Of The Chernobyl Amentioning

confidence: 99%

The Chernobyl Accident and its Consequences

et al. 2011

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“…To obtain the required baseline data, the present baseline survey was instituted by the FHM body, which was completed within three years of the Fukushima accident. It is unlikely that symptoms of thyroid cancer due to radiation had developed before this time point partly because an increase in thyroid cancer was reported to start only four to five years after the Chernobyl accident [1][2][3][4].…”

Section: Discussionmentioning

confidence: 99%

The protocol and preliminary baseline survey results of the thyroid ultrasound examination in Fukushima [Rapid Communication]

et al. 2016

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Abstract. After the Fukushima nuclear power plant accident on March 11, 2011, the public of Japan became particularly concerned about the possibility of an increased risk of childhood thyroid cancer, similar to what was observed after the Chernobyl's accident. Due to serious public health perception, there was an urgency to evaluate the baseline levels of childhood thyroid status in Fukushima prefecture. Therefore we have commenced a thyroid ultrasound examination (TUE) survey of the approximately 360,000 pediatric inhabitants (0 to 18 years of age) who lived in Fukushima at the time of the accident in October 2011. The subjects were divided into three categories according to the standardized diagnostic criteria of ultrasound findings. Category A contained the subjects whose TUE findings were intact or benign. Category B were recommended a confirmatory TUE. Category C was recommended an immediate confirmatory TUE. Results: The survey of 40,302 subjects in the first year was completed in March, 2013. There were 40,097 (99.5%), 205 (0.50%) and 0 subjects in categories A, B and C, respectively. Of the 82 category B subjects who underwent fine needle aspiration cytology (FNAC), 12 were diagnosed with a malignant tumor or were suspected to have malignancy. The 12 subjects received thyroid surgery and 11 thyroid cancers and one benign nodule were confirmed histologically after surgery. This is the first largescaled TUE survey to employ sophisticated ultrasound screening and aim to evaluate the baseline frequency of childhood thyroid nodules and cysts. The results will become the golden standard of future comparative TUE in Fukushima, Japan.Key words: Fukushima, Chernobyl, Ultrasound examination, Nodules, Thyroid cancer first few months after the Fukushima disaster.Due to the issue of concern and a strong request from the central and local governments, the Fukushima Health Management survey (FHM) body initiated several health protection surveys [5], including one that involved thyroid ultrasound examinations (TUE) of all pediatric inhabitants who lived or were staying in Fukushima at the time of the accident. The first objective of this survey was to evaluate the baseline rates of childhood thyroid nodules and cancer in Fukushima as this information was not yet available. The baseline survey commenced on October 9, 2011 [6,7] and was conducted by Fukushima Medical University (FMU). Since it is essentially important to follow the standardized ultrasound diagnostic criteria as a part of quality control when any large-scaled screening, the protocol and the initial data of the baseline TUE survey in Fukushima are reported concretely here for the first time.

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A Cohort Study of Thyroid Cancer and Other Thyroid Diseases After the Chornobyl Accident: Thyroid Cancer in Ukraine Detected During First Screening

Cited by 219 publications

References 22 publications

ret/PTC Activation Is Not Associated with Individual Radiation Dose Estimates in a Pilot Study of Neoplastic Thyroid Nodules Arising in Russian Children and Adults Exposed to Chernobyl Fallout

ret/PTC Activation Is Not Associated with Individual Radiation Dose Estimates in a Pilot Study of Neoplastic Thyroid Nodules Arising in Russian Children and Adults Exposed to Chernobyl Fallout

The Chernobyl Accident and its Consequences

The protocol and preliminary baseline survey results of the thyroid ultrasound examination in Fukushima [Rapid Communication]

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