A coil system for real-time magnetic fluid hyperthermia microscopy studies

Subramanian, Mahendran; Miaskowski, A.; Pearce, Gillian; Dobson, Jon

doi:10.3109/02656736.2015.1104732

Cited by 27 publications

(19 citation statements)

References 18 publications

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“…The use of magnetic nanoparticles (MNPs) in biomedical applications has increased considerably in the recent years [1][2][3]. Several applications of MNPs are reported in the literature, ranging from cell labelling [4] and drug targeting [5] to cancer treatment [6].…”

Section: Introductionmentioning

confidence: 99%

Investigation of magnetite Fe₃O₄ nanoparticles for magnetic hyperthermia

2017

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Abstract. The paper presents the investigation of magnetic nanoparticles (MNPs) dedicated to hyperthermia application. The crystal structure and size distributions have been determined by means of transmission electron microscope (TEM) and X-ray diffraction (XRD). Magnetic properties of the nanoparticles were tested by Mössbauer spectroscopy together with calorimetric experiments. The Mössbauer spectroscopic study of MNPs revealed the existence of a superparamagnetic phase. The relative contribution of the relaxing component to the total spectrum at room temperature was about 10%. The heating effect of these MNPs under alternating magnetic fi eld was examined. The temperature increase has reached 5°C in 10 min. The preliminary temperature rise suggests that the investigated materials are applicable for hyperthermia.

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Section: Introductionmentioning

confidence: 99%

Investigation of magnetite Fe₃O₄ nanoparticles for magnetic hyperthermia

2017

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“…On the other hand, by changing the Peltier elements to other thermoelectric modules with a wider temperature difference between the cool and the hot side, characterization of thermophilic enzymes could also be attained, greatly extending the applicability of this module. PCR [38], [22], [23], lab-on-a-disc [24], protein synthesis [21] Thermoelectric modules (TEM) 20 -100 270 -393 PCR [38], [27], [26], thermal management [39] Microwave (MW) heating 5 -30000 298 -368 ms -s PCR [20], Hydrogel polymerization [31], Flow chemistry/drug discovery [29] Infrared (IR) heating 10 -65 298 -368 ms -s PCR [32], [38], [33], Enzyme inactivation [37] Radio-frequency (RF) heating -298 -373 -MHF [34], inactivation of bacteria [36] A C C E P T E D M A N U S C R I P T…”

Section: Discussionmentioning

confidence: 99%

“…Infrared (IR) heating is another example of an industrially-used heating strategy that has also been applied at the microscale [13,24], with greater emphasis on PCR systems [25]. Radiofrequency (RF) heating for example, which is commonly used on an industrial scale in the food industry, has been used at a microscale to perform magnetic fluid hyperthermia (MFH) on cells [26]. In this technique cells are labelled with magnetic nanoparticles, that increase in temperature when subjected to an alternating current magnetic field (e.g.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…In this technique cells are labelled with magnetic nanoparticles, that increase in temperature when subjected to an alternating current magnetic field (e.g. generated in copper coils integrated in a microchip [26]), thus causing temperature denaturation of the target cells. MFH has also been applied for inactivation of bacteria [27].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Caught in-between: System for in-flow inactivation of enzymes as an intermediary step in “plug-and-play” microfluidic platforms

et al. 2018

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The need for fast and comprehensive characterization of biocatalysts has pushed the development of new screening platforms based on microfluidics, capable of monitoring several parameters simultaneously, with new configurations of liquid handling, sample treatment and sensing. Modular microfluidics allows the integration of these newly developed approaches in a more flexible way towards increasing applicability of the microfluidic chips to different types of biocatalysts and reactions. A highly relevant operation in such a system is biocatalyst inactivation, which can enable the precise control of reaction time by avoiding the continuation of the reaction in another module or connecting tubes. Such control is important when different modules of reactors and/or sensing units are used and changed frequently. Here we describe the development, characterization and application of a module for rapid enzyme inactivation. The thermal inactivation platform developed is compared with a standard benchtop ThermoMixer in terms of inactivation efficiency for glucose oxidase and catalase. A higher activity loss was observed for enzyme inactivation under flow conditions (inactivation achieved at 120 s residence time at 338 K and 20 s residence time at 353 K) which indicated a high heat transfer to the fluid under dynamic conditions. Moreover, partial deactivation of the enzymes was observed for the continuous thermal inactivation module, when activity measurements were performed after 1 and 2 days following inactivation. The thermal inactivation unit presented can be easily integrated into modular microfluidic platforms and can be a useful addition for enzyme characterization and screening.

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“…In external magnetic fi elds they can be useful as contrast agents for magnetic resonance imaging (MRI) [6,7], as colloidal mediators for the treatment of cancer using magnetic hyperthermia [8,9] or as intelligent drug delivery systems [6]. In medical applications, the most common MNPs are iron oxides, especially magnetite and maghemite.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of iron oxide magnetic nanoparticles

et al. 2017

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Abstract. Small particles of magnetite, i.e. 7.5, 13.4 and 14.1 nm in diameter, were obtained by the method of co-precipitation. The crystal structure and size distributions were determined by means of transmission electron microscopy and X-ray diffraction. The magnetic properties of the nanoparticles were tested by Mössbauer spectroscopy within the temperature range from 3 K to room temperature (RT). The Mössbauer study of magnetic nanoparticles reveals relaxation behaviour related to the existence of the superparamagnetic phase. The blocking temperature depends on the sizes of the nanoparticles and the ammonia concentration.

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A coil system for real-time magnetic fluid hyperthermia microscopy studies

Cited by 27 publications

References 18 publications

Investigation of magnetite Fe₃O₄ nanoparticles for magnetic hyperthermia

Investigation of magnetite Fe₃O₄ nanoparticles for magnetic hyperthermia

Caught in-between: System for in-flow inactivation of enzymes as an intermediary step in “plug-and-play” microfluidic platforms

Synthesis and characterization of iron oxide magnetic nanoparticles

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A coil system for real-time magnetic fluid hyperthermia microscopy studies

Cited by 27 publications

References 18 publications

Investigation of magnetite Fe3O4 nanoparticles for magnetic hyperthermia

Investigation of magnetite Fe3O4 nanoparticles for magnetic hyperthermia

Caught in-between: System for in-flow inactivation of enzymes as an intermediary step in “plug-and-play” microfluidic platforms

Synthesis and characterization of iron oxide magnetic nanoparticles

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Investigation of magnetite Fe₃O₄ nanoparticles for magnetic hyperthermia

Investigation of magnetite Fe₃O₄ nanoparticles for magnetic hyperthermia