A column radioimmunoassay method for the determination of digoxin

Boguslaski, Robert C.; Denning, C.E.

doi:10.1016/0006-2944(75)90022-8

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…This demonstrates cross-reactions of these steroids with the digoxin antiserum. In the column radioimmunoassay method of Boguslaski and Denning (1975), progesterone and testosterone in concentrations well above the normal physiological range (up to 1000 ns/ml) did not cross-react with the digoxin antiserum. Langone and Van Vunakis (I 982), on the other hand, state that in their experience, testosterone and progesterone have been the most reactive of the endogenous steroid hormones.…”

Section: Progesterone and Testosteronementioning

confidence: 94%

“…The extent of spironolactone interference with the digoxin assay is apparently influenced by the Kubasik et al (1975) Column RIA 0.6% cross-reactivity Boguslaski and Denning (1975) 3H-RIA 20 ng/ml In vitro solution + (0.9-3.3 ng/ml) Boink et al (1977) Hakiem et al (1982) Abbreviations: + indicates elevation; -indicates reduction; RIA = radioimmunoassay; EMIT = homogeneous enzyme immunoassay; FIA = fluoroimmunoassay.…”

Section: Spironolactonementioning

confidence: 99%

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Drug Interferences with Plasma Assays in Therapeutic Drug Monitoring

Yosselson-Superstine

1984

Clinical Pharmacokinetics

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In this article, many of the reports which describe the various assay procedures for 8 of the most commonly monitored drugs in plasma (digoxin, gentamicin, phenobarbitone, phenytoin, procainamide, quinidine, salicylates and theophylline) are reviewed, together with studies dealing with interferences of other drugs with these assays. Factors which are evaluated include whether the interference was studied when the drug was taken by a patient or a volunteer or by adding it to serum in vitro, the concentration or dose of the interfering drug (when reported), and the clinical implications of the interference. Suggestions as to how to eliminate some of these potential sources of interference are made.

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Section: Progesterone and Testosteronementioning

confidence: 94%

Section: Spironolactonementioning

confidence: 99%

Drug Interferences with Plasma Assays in Therapeutic Drug Monitoring

Yosselson-Superstine

1984

Clinical Pharmacokinetics

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“…The columns containing immobilized antibody were prepared as previously described (15). The concentration of antibody sites in the solid phase preparation was determined from Scatchard analysis ( 16) as previously reported (14).…”

Section: Methodsmentioning

confidence: 99%