A Combination of &amp;delta;-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells

Eitsuka, Takahiro; Tatewaki, Naoto; Nishida, Hiroshi; Nakagawa, Kiyotaka; Miyazawa, Teruo

doi:10.3177/jnsv.62.281

Cited by 23 publications

(17 citation statements)

References 29 publications

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“…The anti-neoplastic effects of T3 have been extensively studied using tumor cells of mammary gland [351][352][353][354][355][356], lung [357][358][359][360][361][362], liver [363][364][365][366][367] pancreas [368], prostate [362,[369][370][371][372], cervix [373,374], skin [362,[375][376][377], brain [357][358][359]378], stomach [379], and colon [378,380]. Besides that, T3 tends to accumulate in the liver and pancreatic tissues as well as tumor tissues with an unknown mechanism [367,381].…”

Section: Effects Of Tocotrienol On Cancersmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

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Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.Nutrients 2020, 12, 259 2 of 84 Nutrients 2020, 12, 259 4 of 84 the order δ > γ > β > α [45]. Using HepG2 cells, γT3 was shown to stimulate apolipoprotein B (Apo-B) degradation by decreasing its translocation into the endoplasmic reticulum (ER) lumen. This action eventually caused a reduction in the number of Apo-B in lipoprotein particles [46]. Other reports showed that γT3 and δT3 had the potential to reduce the hepatic TG synthesis and very-low-density lipoprotein (VLDL) secretion by suppressing expression of genes involved in lipid homeostasis, particularly the TG, cholesterol, and VLDL biosynthesis. Moreover, δT3 also promoted the efflux of LDL through LDL receptor expression [47]. A summary of the literature on effect of T3 supplementation on lipid profile of hypercholesterolemic model in vitro is shown in Table 1.Animal models of dyslipidemia have been used to investigate the effects of T3 on lipid profile. Several animals have been tested, including chicken, swine and rodents (rats, hamsters, guinea pigs). In chickens fed with a varying level of αTF and γT3, Qureshi et al. (1996) showed that αTF enhanced the inhibition of HMGCR by γT3. They further stipulated that the vitamin E mixture should contain 15-20% of αTF and approximately 60% of γT3 or δT3 for optimal anti-cholesterol effects [48]. In the subsequent study, demonstrated that combination of 50 ppm T3-rich fraction (TRF) and 50 ppm lovastatin was more effective in suppressing HMGCR activity compared to lovastatin alone in chickens. The combination also reduced serum TC and LDL-C, TG, Apo-B, thromboxane B 2 , and platelet factor 4 in contrast to individual treatment [49]. Using chicken supplemented with 50 ppm of δT3, Qureshi et al. (2011) further revealed that δT3 reduced TC and LDL-C besides suppressing the lipid elevating effects of dexamethasone and potentiated the TG-lowering effect of riboflavin [50]. Using genetically hypercholesterolemic swine, Qureshi et al. (1991) demonstrated the significant effect of TRF in lowering serum TC, LDL-C, Apo-B, thrombo...

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Section: Effects Of Tocotrienol On Cancersmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

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“…It was recently, reported that T3 controls the synthesis and metabolism of intrinsic sphingolipids, including GlcCer, in the colon and pancreatic cancer cells in vitro 23,24 . Additionally, when both T3 and free FA are added to the colon and pancreatic cancer cells in vitro, intracellular T3 concentrations are higher than when T3 is added alone 25,26 . This increases the apoptotic effects on cancer cells.…”

Section: Discussionmentioning

confidence: 96%

Extraction of Lipophilic Fraction from Polished Rice Improves Its Ameliorative Effect on Intestinal Impairment

et al. 2019

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Introduction Recently, the incidence rate of intestinal impairments, such as colon cancer and inflammatory bowel disease IBD , has increased in East Asian countries, including Japan, while that in the Western countries still remains high 1, 2. It is difficult to recover completely from IBD and these patients have an increased risk of developing colon cancer 3. In our previous research, we had suggested that the induction of inflammation-related cytokines has a connection with the formation of aberrant crypt foci ACF , which are precursors of colon cancer 4. Epidemiological studies indicate that colon cancer is strongly associated

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“…Likewise, in another study, the same researchers demonstrated that the combination of FA and δ-T3 significantly decreases cellular telomerase activity in colorectal adenocarcinoma cells. Moreover, it was thought that FA increases the bioavailability of δ-T3 (46). In a study conducted with breast cancer cells, it was shown that FA renders cancer cells more hypersensitive to ABT-888, poly In this study, to demonstrate the efficacy of FA in combination therapy, a combination dose was primarily determined considering the IC 50 doses of FA and gemcitabine.…”

Section: Discussionmentioning

confidence: 99%

The Combination Effect of Ferulic Acid and Gemcitabine on Expression of Genes Related Apoptosis and Metastasis in PC-3 Prostate Cancer Cells

Eroğlu¹,

Avcı²,

Seçme³

et al. 2019

Eur J Biol

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A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells

Cited by 23 publications

References 29 publications

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Extraction of Lipophilic Fraction from Polished Rice Improves Its Ameliorative Effect on Intestinal Impairment

The Combination Effect of Ferulic Acid and Gemcitabine on Expression of Genes Related Apoptosis and Metastasis in PC-3 Prostate Cancer Cells

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