A combination of six psychoactive pharmaceuticals at environmental concentrations alter the locomotory behavior of clonal marbled crayfish

Hossain, Shakhawate; Kubec, Jan; Guo, Wei; Roje, Sara; Ložek, Filip; Grabicová, Kateřina; Randák, Tomáš; Kouba, Antonín; Buřič, Miloš

doi:10.1016/j.scitotenv.2020.141383

Cited by 21 publications

(12 citation statements)

References 71 publications

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“…Our results add to the growing knowledge regarding the high tolerance of marbled crayfish to multiple single and combined stressors (Kaldre et al 2015;Guo et al 2019;Hossain et al 2021;Stara et al 2021). Such tolerance, in combination with fast growth, high fecundity and parthenogenetic mode of reproduction, prime it for becoming one of the most successful crayfish invaders.…”

Section: Discussionsupporting

confidence: 56%

Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish

Dobrović¹,

Geček²,

Klanjšček³

et al. 2022

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Invasive alien crayfish threaten the diversity of freshwater ecosystems and native crayfish fauna. In Europe, this is largely due to transmission of the crayfish plague to susceptible native crayfish. Many invasive species tolerate crayfish plague, but the infection still has the potential to reduce the fitness of a tolerant host due to energy trade-offs between immune response maintenance and life-history traits, such as growth and reproduction. In combination with other unfavourable conditions, such a response could alter further invasion success of an otherwise successful crayfish invader. We examined whether repeated infection with one of the most virulent haplogroups of crayfish plague agent (Aphanomyces astaci) affects growth or survival of the juvenile marbled crayfish (Procambarus virginalis). Juveniles were exposed to i) two levels of pathogen concentrations, and ii) two different feeding regimes under the higher pathogen concentration. In all performed trials, repeated infection reduced growth rates, while the combination of recurring infection and food limitation significantly increased mortality. The average energy cost of the immune response was estimated at 12.07 J/day for individuals weighing 0.3 grams. Since infections were frequent and pathogen concentrations high, results suggest that marbled crayfish is resistant to A. astaci pathogen and its survival is only affected by adding the stress of food limitation. The survival of almost half of the individuals exposed to high pathogen loads and extreme food limitation indicates that chronic infection by crayfish plague is unlikely to be an important factor impeding invasion success of the marbled crayfish, even under harsh conditions. Our results add to the growing body of evidence that marbled crayfish has potential to become one of the most successful freshwater invaders.

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Section: Discussionsupporting

confidence: 56%

Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish

Dobrović¹,

Geček²,

Klanjšček³

et al. 2022

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“…Once released in the aquatic environment, these compounds can undergo chemical reactions and generate new chemicals, that might also be harmful and therefore need to be identified. Although there is no consistent literature data on the ecotoxicity of these compounds, it has been found that acute and chronic exposure of SER and CIT show effects on algae [ 5 ], crustaceous [ 6 , 7 , 8 ], bivalves [ 9 , 10 ] and fish [ 11 ]. As well, Villain et al classified these 3 drugs as class 1 toxicity, where metabolites should be analyzed in priority and the ecotoxicity can be estimated with QSAR models [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phototransformation of Three Psychoactive Drugs in Presence of Sedimental Water Extractable Organic Matter

2021

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Psychoactive drugs are classified as contaminants of emerging concern but there is limited information on their fate in surface waters. Here, we studied the photodegradation of three psychoactive drugs (sertraline, clozapine, and citalopram) in the presence of organic matter (WEOM) extracted under mild conditions from sediment of Lake Pamvotis, Greece. Spectral characterization of WEOM confirmed its humic-like nature. Preliminary experiments using chemical probes showed that WEOM was able to produce oxidant triplet excited state (3WEOM*), singlet oxygen (1O2), and hydroxyl radicals under irradiation with simulated solar light. Then, WEOM at 5 mgC L−1 was irradiated in the presence of the three drugs. It enhanced their phototransformation by a factor of 2, 4.2, and 16 for sertraline, clozapine, and citalopram, respectively. The drastic inhibiting effect of 2-propanol (5 × 10−3 M) on the reactions demonstrated that hydroxyl radical was the key intermediate responsible for drugs photodegradation. A series of photoproducts were identified by ultra-high performance liquid chromatography (UHPLC) coupled to high resolution mass spectrometry (HR-MS). The photodegradation of the three drugs proceeded through several pathways, in particular oxidations of the rings with or without O atom inclusion, N elimination, and substitution of the halogen by OH. The formation of halogenated aromatics was observed for sertraline. To conclude, sedimental natural organic matter can significantly phototransform the studied antidepressant drugs and these reactions need to be more investigated. Finally, ecotoxicity was estimated for the three target analytes and their photoproducts, using the Ecological Structure Activity Relationships (ECOSAR) computer program.

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“…When aquatic organisms were exposed to a mixture of pollutants at the same time, the toxicity of those pollutants to organisms may be superimposed or reduced. (Lari et al, 2017;Liu et al, 2018;Bachour et al, 2020;Hossain et al, 2021). It was revealed that the 1:1 binary mixture of CTP and tramadol caused signi cant decrease swimming activity of zebra sh during dark conditions in comparison with individuals CTP and tramadol (Backhaus, 2016).…”

Section: Introductionmentioning

confidence: 94%

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

Ma¹,

Li²,

Wei³

et al. 2021

Preprint

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Citalopram (CTP) and mirtazapine (MTP) are two typical psychoactive drugs used for the treatment of depression. As emerging pollutants, CTP and MTP are of widely concern because they are active substances for organisms. However, the studies about the toxicity potential of CTP/MTP pollution to aquatic organisms were limited. In the present study, the effects of CTP and MTP on the feeding behavior, heartbeat, nutritional enzymes and related gene expressions of Daphnia magna were investigated under single and mixed environmental stress. Meanwhile, the recovery of exposed D. magna was studied to analyze the toxic persistence of those pollutants. After 24 h of exposure, the ingestion rate decreased significantly under 1.45 mg/L of CTP. In the mixed treatment groups, no significant synergistic effect of CTM and MTP on daphnia’ feeding inhibition was found. After 24 h of recovery, the feeding behavior of D. magna was stimulated by compensatory stimulation. At exposure period, the heartbeat rate of exposed D. magna increased significantly, and was recovered during the recovery period. The activity of α-amylase (AMS) and trypsin, and their relative gene expression were significantly changed in most of the exposed daphnia, both in the exposure period and recovery period. But there were different responses between gene transcription with enzyme activity. In general, psychoactive drugs have an obvious toxic threat to aquatic organisms, and after acute exposure, the physiological function of D. magna could be recovered to a certain extent. The results were helpful to evaluate the ecological risk of psychotropic drugs in aquatic environments.

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A combination of six psychoactive pharmaceuticals at environmental concentrations alter the locomotory behavior of clonal marbled crayfish

Cited by 21 publications

References 71 publications

Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish

Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish

Phototransformation of Three Psychoactive Drugs in Presence of Sedimental Water Extractable Organic Matter

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

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A combination of six psychoactive pharmaceuticals at environmental concentrations alter the locomotory behavior of clonal marbled crayfish

Cited by 21 publications

References 71 publications

﻿Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish

﻿Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish

Phototransformation of Three Psychoactive Drugs in Presence of Sedimental Water Extractable Organic Matter

Combined Toxicity and Toxicity Persistence of Antidepressants Citalopram and Mirtazapine to Zooplankton Daphnia Magna

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Product

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Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish

Recurring infection by crayfish plague pathogen only marginally affects survival and growth of marbled crayfish